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Experimental Stress and Immunity: Past, Present and Future

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Stress and Tension Control 3

Abstract

Emotional stress represents a human plague and has always been present from the beginning of mankind (Nikolov & Sudakov, 1985). Increasing scientific evidence supports age-old observations that stress is closely associated with changes in immunity Naturally occurring life stress often correlates with immunosuppression.

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References

  • Ader, R., and Cohen, N. (1975). Behaviorally conditioned immunosuppression. Psychosomatic Medicine, 37, 333–340.

    PubMed  Google Scholar 

  • Axelford, J., and Reisine, T.D. (1984). Stress hormones: their interaction and regulation. Science, 224, 452–459.

    Article  Google Scholar 

  • Bahnson, C.B. (1980) Stress and cancer: the state of the art. Psychosomatics, 21, 975–981.

    PubMed  Google Scholar 

  • Bartrop, R.W., Luckhurst, E., Lazarus, L., Rilch, G., and Penny, R. (1977). Depressed lymphocyte function after bereavement. Lancet, 1, 834–836.

    Article  PubMed  Google Scholar 

  • Berenbaum, M.C., Fluck, P.A., and Hurst, N.P. (1973). Depression of lymphocyte response after surgical trauma. British Journal of Experimental Pathology, 54, 597–607.

    PubMed  Google Scholar 

  • Borysenko, J.Z. (1982a). Behavioural-physiological factors in the development and management of cancer. General Hospital Psychiatry, 4, 69–74.

    Article  PubMed  Google Scholar 

  • Borysenko, M., and Borysenko, J. (1982b). Stress, behaviour, and immunity: animal models and mediating mechanisms. General Hospital Psychiatry, 4, 59–67.

    Article  PubMed  Google Scholar 

  • Cannon, W.B. (1922). What strong emotions do to us. Harper’s Magazine, 234–241.

    Google Scholar 

  • Cannon, W.B. (1939). Law of denervation (Hughlings Jackson Memorial Lecture). American Journal of Medical Science, 198, 737–750.

    Article  Google Scholar 

  • Cappel, R., Gregoire, F., Thiry, L., and Sprecher, S. (1978). Antibody and cell mediated immunity to herpes simplex virus in psychotic depression. Journal of Clinical Psychiatry, 39, 266–268.

    PubMed  Google Scholar 

  • Carter, W.R., Herrman, J., Stokes, K., and Cox, D.J. (1987). Promotion of diabetes onset by stress in the BB rat. Diabetologia, 30, 674–675.

    PubMed  Google Scholar 

  • Cohen-Cole, S., Cogen, R., Stevens, A., Kirk, K., Gaitan, E., Hain, J., and Freeman, A. (1981). Psychological, endocrine and immune factors in acute necrotizing ulcerative gingivitis (“trenchmouth”). Psychosomatic Medicine, 43, 91–95.

    Google Scholar 

  • Croiset, G., Heijnen, C.J., Veldhuis, H.D., de Wied, D., and Ballieux, R.E. (1987). Modulation of immune response by emotional stress. Life Sciences, 40, 775–782.

    Article  PubMed  Google Scholar 

  • Crosby, L. (1986) Stress factors. Emotional stress and rheumatoid arthritis disease activity. Arthritis and Rheumatology, Suppl. 4, 29, s151 - s156.

    Google Scholar 

  • Cullen, B.F., and Van Belle, G. (1975). Lymphocyte transformation and changes in leukocyte counts–effect of anaesthesia and operation. Anesthesiology, 43, 563–569.

    Article  PubMed  Google Scholar 

  • Cunningham, A.J., and Szenberg, A. (1968). Further improvements with plaque technique for detecting single antibody-forming cells. Immunology, 14, 599–600.

    PubMed  Google Scholar 

  • Dorian, B., Garfinkel, P., Brown, G., Shore, A., Gladman, D., and Keystone, E. (1982). Aberrations in lymphocyte subpopulations and functions during psychological stress. Clinical and Experimental Immunology, 50, 132–138.

    PubMed  Google Scholar 

  • Dorian, B., Garfinkel, P., Keystone, E., Groczynski, R., Garner, D., Darby, P., and Shore, A. (1985). Occupational stress and immunity. Psychosomatic Medicine, 47, 77–83.

    Google Scholar 

  • Dorian, B., Garfinkel, P., Brown, G., Shore, A., Gladman, D., Keystone, E., and Darby, P. (1986). Stress, immunity and illness. Psychosomatic Medicine, 48, 304–311

    Google Scholar 

  • Dorian, B., and Garfinkel, P. (1987). Stress, immunity and illness–a review. Psychological Medicine, 17, 393–407.

    Article  PubMed  Google Scholar 

  • Eduards, E.A., and Dean, L.M. (1977). Effect of crowding of mice on humoral antibody formation and protection to lethal antigenic challenge. Psychosomatic Medicine, 39, 19–24.

    Google Scholar 

  • Engel, G.L. (1960). A unified concept of health and disease. Perspectives in Biology and Medicine, 3, 459–485.

    PubMed  Google Scholar 

  • Feigenbaum, S.L., Masi, A.T., and Kaplan, S.B. (1979). Prognosis in rheumatoid arthritis: a longitudinal study of newly diagnosed young adult patients. American Journal of Medicine, 66, 377–384.

    Article  PubMed  Google Scholar 

  • Fox, B.H. (1981). Psychological factors in the immune system in human cancer. In: R. Ader (Ed.), Psichoneuroimmunology, New York: Academic Press.

    Google Scholar 

  • Glaser, R., Kiecolt-Glaser, J.K., Speicher, C.E., and Holliday, J.E. (1985). Stress, loneliness, and changes in herpes virus latency. Journal of Behavioural Medicine, 8, 249–260.

    Article  Google Scholar 

  • Glaser, R., and Kiecolt-Glaser, J.K. (1986). Stress and immune function. Clinical Neuropharmacology, Suppl. 4, 9, 485–487.

    Google Scholar 

  • Goetzl, E.J. (1985). Neuromodulation of immunity and hypersensitivity. Journal of Immunology, 135, 739S - 863S.

    Google Scholar 

  • Greer, S. (1983). Cancer and the mind. British Journal of Psychiatry, 143, 535–543.

    Article  PubMed  Google Scholar 

  • Grossmann, C.J., and Roselle, G.A. (1986). Regulation of the immune response by adrenal hormones. Progress in Clinical Biochemistry and Medicine, 4, 18–21.

    Article  Google Scholar 

  • Huang, S.W., Plant, S.M., Taylor, B., and Warenheim, A. (1981). Effect of stressful stimulation on the incidence of streptozotocin-induced diabetes in mice. Psychosomatic Medicine, 43, 431–437.

    PubMed  Google Scholar 

  • Jankovic, B.D. (1987). Neuroimmune interactions: experimental and clinical strategies. Immunology Letters, 16, 341–354.

    Article  PubMed  Google Scholar 

  • Jemmott, J.B., Borysenko, J.Z., Borysenko, M.C., McClelland, D.C., Chapman, R., Meyer, D.J., and Benson, H. (1983). Academic stress, power motivation, and decrease in secretion rate of salivary immunoglobulin A. Lancet, 1, 1400–1402.

    Article  PubMed  Google Scholar 

  • Kasl, S.V., Evans, A.S., and Weidermann, J.C. (1979). Psychosocial risk factors in the development of infectious mononucleosis..Psychosomatic Medicine, 41, 445–466.

    Google Scholar 

  • Kiecolt-Glaser, J.K., Speicher, C.E., Holliday, J.E., and Glaser, R. (1984). Stress and the transformation of lymphocytes by Epstein-Barr virus. Journal of Behavioural Medicine, 7, 1–12.

    Article  Google Scholar 

  • Koehler, T. (1985). Stress and rheumatoid arthritis. A survey of empirical evidence in human and animal studies. Journal of Psychosomatic Research, 29, 655–663.

    Article  PubMed  Google Scholar 

  • Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R., and Carroll, B. (1983). Impared lymphocyte function in depressive illness. Life Sciences, 33, 241–247.

    Article  PubMed  Google Scholar 

  • Levi, L. (1872). Prevention of stress related disorders on a population scale. International Journal of Mental Health, 9, 9–26.

    Google Scholar 

  • Levy, S., Herberman, R., Lippman, M., and d’Angelo, T. (1987). Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. Journal of Clinical Oncology, 5, 348–353.

    PubMed  Google Scholar 

  • Liew, F.J. (1982). Regulation of delayed-type hypersensitivity to pathogens and alloantigens. Immunology Today, 3, 18–23.

    Article  Google Scholar 

  • Linn, B.S., Linn, M.W., and Jensen, J. (1982). Degree of depression and immune responsiveness. Psychosomatic Medicine, 44, 128–129.

    Google Scholar 

  • Linn, B.S., and Jensen, J. (1983a). Age and immune responses to a surgical stress. Archives of Surgery, 118, 405–409.

    Article  PubMed  Google Scholar 

  • Linn, M.W., Linn, B.S., Skyler, J.S., and Jensen, J. (1983b). Stress and immune function in diabetes mellitus. Clinical Immunology and Immunopathology, 27, 223–233.

    Article  PubMed  Google Scholar 

  • Locke, S.E. (1982). Stress, adaptation and immunity. Studies in humans. General Hospital Psychiatry, 4, 49–58.

    Article  PubMed  Google Scholar 

  • Locke, S.E., Kraus, L., Leserman, J.M., Hurst, M.W., Heisel, S., and Williams, R.M. (1984). Life change stress, psychiatric symptoms and natural killer cell activity. Psychosomatic Medicine, 45, 441–453.

    Google Scholar 

  • Luborsky, L., Minta, V.J., Brightman, V.J., and Katcher, A.h. (1976). Herpes simplex virus and moods: a longitudinal study. Journal of Psychosomatic Research, 20, 543–548.

    Article  PubMed  Google Scholar 

  • Luster, M.I., and Blanck, J.A. (1987). Molecular and cellular basis of chemically induced immunotoxicity. Annual Reviews in Toxicology, 27, 23–49.

    Article  Google Scholar 

  • Maestroni, G.I.M., Conti, A., and Pierpaoli, W. (1988). Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology, 63, 465–469.

    PubMed  Google Scholar 

  • McCain, H.W., Bilotta, J., and Lamster, I.B. (1987). Endorphinergic modulation of immune function: potent action of the dipeptide glycyl-L-glutamine. Life Sciences, 41, 169–176.

    Article  PubMed  Google Scholar 

  • McClelland, D.C., Alexander, C., and Marks, E. (1982). The need for power, stress, immune function and illness among male prisoners. Journal of Abnormal Psychology, 91, 61–70.

    Article  PubMed  Google Scholar 

  • McGuigan F.J. (1981). Calm Down. A Guide to Stress and Tension Control. New Jersey, Prentice-Hall Inc.

    Google Scholar 

  • Metalnikov, S., and Chorine, V. (1926). The role of conditioned reflexes in immunity. Annals of Pasteur Institute, 40, 893–900.

    Google Scholar 

  • Meyerowitz, S., Jacox, R.F., and Hess, D.W. (1968). Monozygotic twins discordant for rheumatoid arthritis; a genetic, clinical and psychological study of 8 sets. Arthritis and Rheumatology, 11, 1–21.

    Article  Google Scholar 

  • Nikolov, N.A., and Sudakov, KV. (1985). Emotional Stress. Sofia, Medizina and Fiskultura.

    Google Scholar 

  • Odio, M., Golisek, A., and Ricardo, M.J.Jr. (1986). Impairment of immune function after cessation of long term chronic stress. Immunology Letters, 13, 25–31.

    Article  PubMed  Google Scholar 

  • Plotnikoff, N.P., Faith, B.E., Murgo, A.J., and Good, R.A. (1986). Enkephalins and Endorphins: Stress and the Immune System. New York, Plenum Press.

    Google Scholar 

  • Rimon, R., Haloneu, P., Anttineu, E., and Evola, E. (1971). Complement fixing antibody to herpes simplex virus in patients with psychotic depression. Diseases of the Nervous System, 32, 822–824.

    PubMed  Google Scholar 

  • Robinson, N., and Fuller, J.H. (1986). Severe life events and their relationship to the aetiology of insulin-dependent (Type I) diabetes mellitus. Pediatric and Adolescence Endocrinology, 15, 129–133.

    Google Scholar 

  • Rogers, M.P., Dubey, D., and Reich, P. (1979). The influence of the psyche and the brain on immunity and disease susceptibility: a critical review. Psychosomatic Medicine, 41, 147–164.

    PubMed  Google Scholar 

  • Rogers, M.P., Trentham, D.E., McCune, W.J., Guisberg, B.I., Rennke, H.G., Reike, P., and David, J.R. (1980). Effect of psychological stress on the induction of arthritis in rats. Arthritis and Rheumatology, 23, 1337–1342.

    Article  Google Scholar 

  • Salk, J. (1962). Biological basis of disease and behaviour. Perspectives in Biology and Medicine, 5, 198–206.

    PubMed  Google Scholar 

  • Salo, M. (1982).. Effects of anaesthesia and surgery on the immune response. In: J. Watkins (Ed.), Trauma, Stress and Immunity in Anaesthesia and Surgery. London, Butterworth & Co., ( Publishers) Ltd.

    Google Scholar 

  • Schindler, B.A. (1985). Stress, affective disorders and immune function. Medical Clinics of North America, 69, 585–597.

    PubMed  Google Scholar 

  • Schleifer, S., Keller, S., Meyerson, A., Raskin, M.J., Davis, K.L., and Stein, M. (1984). Lymphocyte function in major depressive disorder. Archives of General Psychiatry, 41, 484–486.

    Article  PubMed  Google Scholar 

  • Schleifer, S.J., Keller, S.E., Siris, S.G., Davis, K.L., and Stein, M. (1985). Depression and immunity. Lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients hospitalized for herniorrahaphy. Archives of General Psychiatry, 42, 129–133.

    Article  PubMed  Google Scholar 

  • Selye, H. (1952). The Story of the Adaptation Syndrome. Montreal, Acta Inc. Med. Publ.

    Google Scholar 

  • Solomon, G.F. (1981). Emotional and personality factors in the onset and course of autoimmune disease, particularly rheumatoid arthritis. In: R. Ader (Ed.), Psychoneuroimmunology, New York, Academic Press.

    Google Scholar 

  • Solomon, G.F. (1987). Psychoneuroimmunology: interaction between central nervous system and immune system. Journal of Neuroscience Research, 18, 1–9.

    Article  PubMed  Google Scholar 

  • Stein, S.P., and Charles, E. (1971). Emotional factors in juvenile diabetes mellitus. American Journal of Psychiatry, 128, 56–60.

    Google Scholar 

  • Stein, M., Keller, S.E., and Schleifer, S.J. (1985). Stress and immunomodulation; the role of depression and neuroendocrine function. Journal of Immunology, 135, 827–833.

    Google Scholar 

  • Sudakov, K.V. (1977). Acute experimental emotional stress and natural history of arterial hypertension. Physiology and Behaviour, 19, 213–221.

    Article  Google Scholar 

  • Sudakov, K.V., Gantan, D., and Nikolov, N. (1982). Emotional stress and arterial hypertension. Agressologie, 23, 193–203.

    Google Scholar 

  • Sukovatykh, T.N., and Zhernosek, V.F. (1986). Characteristics of the course of bronchial asthma with neuropsychological pathogenetic mechanism in children. Zdravookhranenie Belorussia, 8: 14–17.

    Google Scholar 

  • Takino, M. (1971). The role of the autonomic nervous system in pathogenesis of allergy. Japanese Journal of Allergology, 20, 637–652.

    Google Scholar 

  • Totman, R., Kiff, J., Reed, S.E., and Graig, J.W. (1980). Predicting experimental colds in volunteers from different measures of recent life stress. Journal of Psychosomatic Research, 24, 155–163.

    Article  PubMed  Google Scholar 

  • Wallace, D.J. (1987). The role of stress and trauma in rheumatoid arthritis and systemic lupus erythematosus. Seminars in Arthritis and Rheumatology, 16, 153–157.

    Article  Google Scholar 

  • Wehrmacher, W.H., and Randall, W.C. (1984). Performance of the heart in health and disease. In: W.C. Randall (Ed.), Nervous Control of Cardiovascular Function, Oxford, Oxford University Press.

    Google Scholar 

  • Workman, E.A., and LaVia, M.F. (1987). T-lymphocyte polyclonal proliferation: effect of stress and stress response style on medical students taking national board examinations. Clinical Immunology and Immunopathology, 43, 308–313.

    Article  PubMed  Google Scholar 

  • Yamamoto, K. (1982). Proceedings of the 60th Annual Meeting of Kinki District Division of the Japanese Pharmacological Society, 80–83.

    Google Scholar 

  • Yanagihara, Y., Shida, T., and Yoshii, H. (1981). Immunopharmacological actions of neurotropin (1): immunostimulating actions of neurotropin. Folla Phannacologica Japonica, 78, 439–449

    Article  Google Scholar 

  • Yoshii, H., Suehiro, S., and Watanabe, K. (1987). Immunopharmacological actions of an extract isolated from inflamed skin of rabbits inoculated with vaccinia virus (neurotropin); enhancing effect on delayed type hypersensitivity response through the induction of Lyt-1+ 2−T cells. International Journal of Immunophannacology, 9, 443–451.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute for State Control of Drugs, Bulgarian Medical Academy, Bulgaria

    G. Guencheva & P. Popova

  2. Institute for Stress Management, United States International University, San Diego, USA

    F. J. McGuigan

  3. Department of Pathophysiology, Scientific Medico-Biological Institute, Bulgarian Medical Academy, Bulgaria

    N. Nikolov

Authors
  1. G. Guencheva
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  2. P. Popova
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  3. F. J. McGuigan
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  4. N. Nikolov
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Editor information

Editors and Affiliations

  1. Institute for Stress Management, United States International University, San Diego, California, USA

    F. J. McGuigan

  2. Biofeedback and Stress Management, University of Nebraska, Lincoln, Nebraska, USA

    Wesley E. Sime

  3. West London Institute of Higher Education, London, England

    J. Macdonald Wallace (Health Education Consultant) (Health Education Consultant)

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© 1989 Plenum Press, New York

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Guencheva, G., Popova, P., McGuigan, F.J., Nikolov, N. (1989). Experimental Stress and Immunity: Past, Present and Future. In: McGuigan, F.J., Sime, W.E., Wallace, J.M. (eds) Stress and Tension Control 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7915-1_28

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  • DOI: https://doi.org/10.1007/978-1-4615-7915-1_28

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