Abstract
Polymeric materials having antithrombogenic activity are very important and their development is expected in the field of artificial organs such as the artificial vessel or the devices for extracorporeal circulation. In previous papers1,2 we described that the binding of sulfonate and amino acid sulfamide groups onto cross- linked polystyrene endows these materials with antithrombic activity which requires the presence of a plasma cofactor, antithrombin mi These insoluble materials operate as catalysts of the inactivation of thrombin by its inhibitor as does soluble heparin2. The catalytic effect of this mucopolysaccharide was demonstrated to require the formation of complexes between heparin and either antithrombin III or thrombin or both4, 5, 6.
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References
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© 1983 Plenum Press, New York
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Fougnot, C., Jozefowicz, M., Rosenberg, R.D. (1983). Interactions of Some Plasmatic Proteins with Anticoagulant Polystyrene Resins: Mechanism of Catalytic Activity Towards the Thrombin— Antithrombin Reaction. In: Chiellini, E., Giusti, P. (eds) Polymers in Medicine. Polymer Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7643-3_19
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DOI: https://doi.org/10.1007/978-1-4615-7643-3_19
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