Inhibitory Amino Acid Neurons: GABA and Glycine
In Chapters 5 and 6 we discussed excitatory ionotropic transmitters. While ACh is well established in this regard, the cholinergic neurons described in Chapter 5 could account for only a small percentage of the total excitatory neurons in brain. It is possible, as suggested in Chapter 6, that many of the remainder are glutamatergic or aspartatergic. We must now consider what transmitters could represent the inhibitory ionotropic neurons, because these are probably as plentiful as the excitatory ones. GABA and glycine are proven inhibitory transmitters that might account for the majority of such cells. Both were ignored as potential transmitters even after their presence in nervous tissue had long been established. It is therefore instructive to recall what indications prompted the critical experiments which led to our appreciation of them as neurotransmitters.
KeywordsPurkinje Cell Nerve Ending Krebs Cycle Gaba Level Deep Cerebellar Nucleus
Unable to display preview. Download preview PDF.