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Chemical Synaptic Transmission at Peripheral Synapses

  • Patrick L. McGeer
  • John C. Eccles
  • Edith G. McGeer

Abstract

In the preceding chapter it was shown how transmission along a nerve fiber occurred by brief all-or-nothing impulses and that this impulse propagation depended on two main factors: first, the cable-like properties of the nerve fiber, the conducting core being ensheathed by a relatively resistant membrane; and second, the large and momentary increase in sodium conductance of this membrane when its resting potential was suddenly diminished. As a consequence, the extremely poor cable-like transmission along the nerve fiber is amplified at each segment in a self-regenerative manner. The all-or-nothing character of the propagation derives from the amplification that each segment of the nerve gives to the attenuated signal transmitted in the manner of a cable from the adjacent active region.

Keywords

Synaptic Vesicle Nerve Terminal Nerve Impulse Postsynaptic Membrane Neuromuscular Transmission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Patrick L. McGeer
    • 1
  • John C. Eccles
    • 2
  • Edith G. McGeer
    • 1
  1. 1.The University of British ColumbiaVancouverCanada
  2. 2.Abteilung NeurobiologieMax-Planck-Institut für Biophysikalische ChemieGöttingenWest Germany

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