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Electroconformational Coupling: A Fundamental Process of Biomolecular Electronics for Signal Transductions

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Molecular Electronics

Summary

Biomolecules are like electronic elements and are built to process information. Proteins of a cell membrane are adept to receive and to decipher even the very weak electromagnetic signals. Experiments on ion channel activity and on electric activation of [Na, K] -ATPase and mitochondrial ATPase reveal a fundamental process of the biomolecular electronics, the “Resonance Electroconformational Coupling”. An alternating electric field of a defined amplitude and frequency is shown to induce oscillation of protein conformers. The process can turn the activity of the protein on and off much like a molecular switch. When coupled to ligand binding it also allows the molecule to use the binding energy of a ligand to drive an endergonic reaction.

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© 1989 Plenum Press, New York

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Tsong, T.Y. (1989). Electroconformational Coupling: A Fundamental Process of Biomolecular Electronics for Signal Transductions. In: Hong, F.T. (eds) Molecular Electronics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7482-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-7482-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7484-2

  • Online ISBN: 978-1-4615-7482-8

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