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Iron Metabolism pp 37–70Cite as

Iron Absorption

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Abstract

A proportion of the food iron is liberated from its organic bond and reduced to ferrous iron in the stomach. The ferrous iron enters the cells of the duodenal and jejunal mucosa and either passes directly into the bloodstream or forms a complex of ferric compounds with apoferritin in the mucosal cells, in which case it remains in the cell and is later desquamated into the gut lumen. The iron that passes across the serosal surface of the mucosal cell into the blood is bound to transferrin and transported to the tissues (Fig. 6/1).

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Bibliography

  • Apte, S. V., Brown, E. B.: Effects of plasma from pregnant women on iron absorption in the rat. Gastroenterology 57, 126 (1969).

    PubMed  CAS  Google Scholar 

  • Badenoch, J., Callender, S. T.: Iron metabolism in steatorrhea. The use of radioactive iron in studies of absorption and utilisation. Blood 9, 123 (1954).

    PubMed  CAS  Google Scholar 

  • Baird, I. M., Wilson, G. H.: The pathogenesis of anaemia after partial gastrectomy. II. Iron absorption after partial gastrectomy. Quart. J. Med. N. S. 28, 35 (1959).

    CAS  Google Scholar 

  • Baird, I. M., Podmore, D. A., Wilson, G. H.: Changes in iron metabolism following gastrectomy and other surgical operations. Clin. Sci. 16, 463 (1957).

    PubMed  CAS  Google Scholar 

  • Balcerzak, S. P., Peternel, W. W., Heinle, E. W.: Iron absorption in chronic pancreatitis. Gastroenterology 53, 257 (1967).

    CAS  Google Scholar 

  • Bannerman, R. M., Malpas, J. S.: Studies on desferrioxamine in relation to the absorption of iron. Brit. J. Haemat. 11, 15 (1965).

    PubMed  CAS  Google Scholar 

  • Banwell, J. G., Hutt, M. S. R., Marsden, P. D., Blackman, V.: Malabsorption syndromes amongst African people in Uganda. E. Afr. med. J. 41, 188 (1964).

    CAS  Google Scholar 

  • Berde, B. et al.: Schweiz. med. Wschr. 85, 936 (1955).

    PubMed  CAS  Google Scholar 

  • Bernát, I.: Unpublished results (1968).

    Google Scholar 

  • Bernát, I., Kovács, E.: Vizsgálatok a normális és kóros vasanyagcsere köréből. II. Adatok a “mucosa block” kérdéséhez (Investigations on the normal and pathological iron metabolism. II. Contributions to the question of the “mucosa block”). Katonaorvosi Szle 8, 725 (1956a).

    Google Scholar 

  • Bernát, I., Kovács, E.: Vizsgálatok a normális és kóros vasanyagesere köréből. III. A vasfelszívódást és a vaskezelés hatásosságát befolyásoló egyes tényezőkről (Investigations on the normal and pathological iron metabolism. III. Factors affecting the iron absorption and the effectivity of iron treatment). Katonaorvosi Szle 8, 882 (1956b).

    Google Scholar 

  • Bernát, I. Jr., Magyar, J., Bernát, I., Mihályi, L.: A plasma vaskoncentrációjának alakulása különféle vaskészítményekkel végzett orális terhelés után (Plasma iron concentrations after oral administration of various iron preparations). Transfusio 11, 5 (1978).

    Google Scholar 

  • Beutler, E., Buttenwieser, E.: The regulation of iron absorption. I. A search for humoral factors. J. Lab. clin. Med. 55, 274 (1960).

    PubMed  CAS  Google Scholar 

  • Bezwoda, W. R., Bothwell, T. H. et al.: The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand. J. Haemat. 22, 113 (1979).

    PubMed  CAS  Google Scholar 

  • Bickel, H., Hall, G. E., Keller-Schierlein, W., Prelog, V., Vischer, E., Wettstein, A.: Stoffwechselprodukte von Actinomyceten, 27. Über die Konstitution von Ferrioxamin-B. Helv. chim. Acta 43, 2129 (1960).

    CAS  Google Scholar 

  • Biggs, J. C., Bannerman, R. M., Callender, S. T.: Proc. 8th Congr. Europ. Soc. Haemat., Vienna 1961.

    Google Scholar 

  • Boender, C. A., Verloop, M. C.: Iron absorption, iron loss and iron retention in man; studies after oral administration of a tracer dose of 59FeSO4 and 131BaSO4. Brit. J. Haemat. 17, 45 (1969).

    PubMed  CAS  Google Scholar 

  • Bolin, T., Davis, A. E.: Iron absorption in infectious hepatitis. Amer. J. dig. Dis. 13, 16 (1968).

    PubMed  CAS  Google Scholar 

  • Bonnet, J. D., Hagedorn, A. B., Owen, C. A.: A quantitative method for measuring the gastrointestinal absorption of iron. Blood 15, 36 (1960).

    PubMed  CAS  Google Scholar 

  • Bothwell, T. H. (1961), cit. Bothwell, Finch, 1962.

    Google Scholar 

  • Bothwell, T. H.: The control of iron absorption. Brit. J. Haemat. 14, 453 (1968).

    PubMed  CAS  Google Scholar 

  • Bothwell, T. H., Finch, C. A.: The intestine in iron metabolism. Its role in normal and abnormal states. Amer. J. dig. Dis. 2, 145 (1957).

    PubMed  CAS  Google Scholar 

  • Bothwell, T. H., Finch, C. A.: Iron Metabolism. Little, Brown and Co., Boston 1962.

    Google Scholar 

  • Bothwell, T. H., Pirzio-Biroli, G., Finch, C. A.: Iron absorption. I. Factors influencing absorption. J. Lab. clin. Med. 51, 24 (1958).

    PubMed  CAS  Google Scholar 

  • Bothwell, T. H., van Doorn-Wittkampf, H. W., du Preez, M. L., Alper, T.: The absorption of iron. Radioiron studies in idiopathic haemochromatosis, malnutritional cytosiderosis, and transfusional hemosiderosis. J. Lab. clin. Med. 41, 836 (1953).

    PubMed  CAS  Google Scholar 

  • Brise, H., Hallberg, L.: Iron absorption studies. II. Effect of succinic acid on iron absorption. Acta med. scand. 171 (Suppl. 376), 59 (1962).

    CAS  Google Scholar 

  • Brittin, G. M., Haley, J., Brecher, G.: Enhancement of intestinal iron absorption by a humoral effect of hypoxia in parabiotic rats. Proc. Soc. exp. Biol. (N. Y.) 128, 178 (1968).

    CAS  Google Scholar 

  • Brown, E. B., Jr., Justus, B. W.: In vitro absorption of radioiron by everted pouches of rat intestine. Amer. J. Physiol. 194, 319 (1958).

    PubMed  CAS  Google Scholar 

  • Brown, E. B., Jr., Dubach, R., Moore, C. V.: Studies on iron transportation and metabolism. XI. Critical analysis of mucosal block by large doses of inorganic iron in human subjects. J. Lab. clin. Med. 52, 335 (1958).

    PubMed  CAS  Google Scholar 

  • Brüschke, G. 1962, cit. Brüschke, G.: Der Eisenstoffwechsel, pp. 22–23. Steinkopff, Dresden-Leipzig 1964.

    Google Scholar 

  • Callender, S. T.: Iron absorption. Brit. med. Bull. 15, 5 (1959).

    PubMed  CAS  Google Scholar 

  • Callender, S. T.: Digestive absorption of iron. In: Gross, F. (ed.): Iron Metabolism. Springer, Berlin-Göttingen-Heidelberg 1964.

    Google Scholar 

  • Callender, S. T., Andrews, St., Warner, G. T.: Iron absorption from bread. Haematologia 5, 369 (1971).

    PubMed  CAS  Google Scholar 

  • Callender, S. T., Malpas, J. S.: Absorption of iron in cirrhosis of the liver. Brit. Med. J. 2, 1516 (1963).

    PubMed  CAS  Google Scholar 

  • Callender, S. T., Marney, S. R., Warner, G. T.: Eggs and iron absorption. Brit. J. Haemat. 19, 657 (1970).

    PubMed  CAS  Google Scholar 

  • Cattau, D., Debray, Ch., Jori, J. P., Marche, C.: Considérations sur le mécanisme régulateur de l’absorption intestinale du fer. Importance des macrophages du chorion villositaire. Une nouvelle théorie. Soc. Méd. Hôp. (Paris) 116, 1653 (1965).

    Google Scholar 

  • Chappelle, E., Gabrio, B. W., Stevens, A. R. Jr., Finch, C. A.: Regulation of body iron content through excretion in the mouse. Am. J. Physiol 182, 390 (1955).

    PubMed  CAS  Google Scholar 

  • Charley, P. J., Stitt, C. F., Shore, E., Saltman, P.: Studies on the regulation of iron absorption. J. Lab. clin. Med. 61, 397 (1963).

    CAS  Google Scholar 

  • Charlton, R. W., Jacobs, P., Seftel, H., Bothwell, T. H.: Effect of alcohol on iron absorption. Brit. Med. J. 2, 1427 (1964).

    PubMed  CAS  Google Scholar 

  • Chase, M. S., Gubler, C. J., Cartwright, G. E., Wintrobe, M. M.: Studies on copper metabolism. IV. The influence of copper on the absorption of iron. J. biol. Chem. 199, 757 (1952).

    PubMed  CAS  Google Scholar 

  • Cheney, B., Finch, C. A.: The effect of inosine on iron absorption in rats. Proc. Soc. exp. Biol. Med. 103, 37 (1960).

    PubMed  CAS  Google Scholar 

  • Chodos, R. B., Ross, J. F., Apt, L., Pollycove, M., Halkett, J. A. E.: The absorption of radioiron labeled foods and iron salts in normal and iron deficient subjects and in idiopathic hemochromatosis. J. clin. Invest. 36, 314 (1957).

    PubMed  CAS  Google Scholar 

  • Conrad, M. E.: Factors affecting iron absorption. In: Hallberg, L., Harwerth, H. G., Vannotti, A. (eds.): Iron Deficiency, pp. 87–114. Academic Press, London-New York 1970.

    Google Scholar 

  • Conrad, M. E., Crosby, W. H.: Intestinal mucosal mechanisms controlling iron absorption. Blood 22, 406 (1963).

    PubMed  CAS  Google Scholar 

  • Conrad, M. E., Benjamin, B. I., Williams, H. L., Foy, A. L.: Human absorption of haemoglobin iron. Gastroenterology 53, 5 (1967).

    PubMed  CAS  Google Scholar 

  • Conrad, M. E., Cortell, E., Williams, H. L., Foy, A. L.: Polymerisation and intraluminal factors in the absorption of hemoglobin iron. J. Lab. clin. Med. 68, 659 (1966).

    PubMed  CAS  Google Scholar 

  • Conrad, M. E., Weintraub, L. R., Sears, D. A., Crosby, W. H.: Absorption of hemoglobin iron. Amer. J. Physiol. 211, 1123(1966).

    PubMed  CAS  Google Scholar 

  • Cook, J. D., Brown, G. M., Valberg, L. S.: The effect of achylia gastrica on iron absorption. J. clin. Invest. 43, 1185(1964).

    Google Scholar 

  • Cook, J. D., Lipschitz, D. A., Miles, L. E. M., Finch, C. A.: Serum ferritin as a measure of iron stores in normal subjects. Amer. J. clin. Nutr. 27, 681 (1974).

    PubMed  CAS  Google Scholar 

  • Croft, D. N.: Body iron loss and cell loss from epithelia. Proc. roy. Soc. Med. 63, 1221 (1970).

    PubMed  CAS  Google Scholar 

  • Crosby, W. H.: The control of iron balance by the intestinal mucosa. Blood 22, 441 (1963).

    PubMed  CAS  Google Scholar 

  • Crosby, W. H., Conrad, M. E., Wheby, M. S.: The rate of iron accumulation in iron storage disease. Blood 22, 429 (1963).

    PubMed  CAS  Google Scholar 

  • Cumming, R. L. C., Smith, J. A., Millar, J. A., Goldberg, A.: The relationship between body iron stores and the rate of ferritin synthesis in rat liver and intestinal mucosa. Brit. J. Haemat. 18, 653 (1970).

    PubMed  CAS  Google Scholar 

  • Dagg, J. H., Cumming, R. L. C., Goldberg, A.: Disorders of iron metabolism. In: Goldberg, A., Brain, M. C. (eds.): Recent Advances in Haematology. Churchill-Livingstone, Edinburgh-London 1971.

    Google Scholar 

  • Dagg, J. H., Kuhn, I. N., Templeton, F. E., Finch, C. A.: Gastric absorption of iron. Gastroenterology 53, 918 (1967).

    PubMed  CAS  Google Scholar 

  • Davis, A. E., Badenoch, J.: Iron absorption in pancreatic disease. Lancet 2, 6 (1962).

    Google Scholar 

  • Davis, P. S., Luke, C. G., Deller, D. J.: Reduction of gastric iron-binding protein in haemo-chromatosis. Lancet 2, 1431 (1966).

    PubMed  CAS  Google Scholar 

  • Dawson, R. B., Rafal, S., Weintraub, L. R.: Absorption of hemoglobin iron: the role of xanthine oxidase in the intestinal heme-splitting reaction. Blood 37, 94 (1970).

    Google Scholar 

  • Deller, D. J.: Iron59 absorption measurements by whole body counting. Studies in alcoholic cirrhosis, haemochromatosis with pancreatitis. Amer. J. dig. Dis. 10, 249 (1965).

    PubMed  CAS  Google Scholar 

  • Deller, D. J., Witts, L. J.: Changes in the blood after partial gastrectomy with special reference to vitamin B12.I. Serum vitamin B12, haemoglobin, serum iron and marrow. Quart. J. Med. N. S. 31, 71 (1962).

    CAS  Google Scholar 

  • Deller, D. J., Edwards, R. G., Dart, G., Luke, C. G., Davis, P. S.: Gastric iron binding substance (gastroferrin) in a family with haemochromatosis. Aust. Ann. Med. 18, 36 (1969).

    PubMed  CAS  Google Scholar 

  • Dowdle, E. B., Schachter, D., Schenker, H.: Active transport of Fe59 by everted segments of rat duodenum. Amer. J. Physiol. 198, 609 (1960).

    PubMed  CAS  Google Scholar 

  • Dubach, R., Callender, S. T., Moore, C. V.: Studies in iron transportation and metabolism. VI. Absorption of radioactive iron in patients with fever and with anaemias of varied etiology. Blood 3, 526 (1948).

    PubMed  CAS  Google Scholar 

  • Everett, N. B., Garrett, W. E., Simmons, B. S.: Lymphatics in iron absorption and transport. Amer. J. Physiol. 178, 45 (1954).

    PubMed  CAS  Google Scholar 

  • Finch, C. A. (1961), cit. Bothwell, Finch, 1962.

    Google Scholar 

  • Finch, C. A.: Diagnostic value of different methods to detect iron deficiency. In: Hallberg, L. et al. (eds.): Iron Deficiency. Academic Press, London-New York 1970.

    Google Scholar 

  • Finch, S. C., Ross, J. F.: The significance of plasma iron turnover. J. clin. Invest. 31, 627 (1952).

    Google Scholar 

  • Fineberg, R. A., Greenberg, D. M.: Ferritin biosynthesis. III. Apoferritin, the initial product. J. biol. Chem. 214, 107 (1955).

    PubMed  CAS  Google Scholar 

  • Fischer, D. S., Price, D. S.: A possible humoral regulator of iron absorption. Proc. Soc. exp. Biol. (N. Y.) 112, 228 (1963).

    CAS  Google Scholar 

  • Gabrio, B. W., Salomon, K.: Distribution of total ferritin in intestine and mesenteric lymph nodes of horses after iron feeding. Proc. Soc. Exp. Biol. Med. 75, 124 (1950).

    PubMed  CAS  Google Scholar 

  • Green, R., Charlton, R., Seftel, H., Bothwell, T. H., Mayet, F., Adams, B., Finch, C. A., Layrisse, M.: Body iron excretion in man. Amer. J. med. 45, 336 (1968).

    PubMed  CAS  Google Scholar 

  • Greenberg, M. S., Strohmeyer, G., Hine, G. J., Keene, W. R., Curtis, G., Chalmers, T. C.: Studies in iron absorption. III. Body radioactivity measurements of patients with liver disease. Gastroenterology 46, 651 (1964).

    PubMed  CAS  Google Scholar 

  • Greenberg, M. S., Wong, H., Miller, S. A., Scarlata, R. W., Chalmers, T. C.: Iron absorption and turnover in hypoxia. J. clin. Invest. 39, 992 (1960).

    Google Scholar 

  • Gross, F.: Iron Metabolism. Springer, Berlin-Göttingen-Heidelberg 1964.

    Google Scholar 

  • Hahn, P. F., Bale, W. F., Ross, J. F., Balfour, W. M., Whipple, G. H.: Radioactive iron absorption by the gastrointestinal tract. Influence of anaemia, anoxia and antecedent feeding. Distribution in growing dogs. J. exp. Med. 78, 169 (1943).

    PubMed  CAS  Google Scholar 

  • Hahn, P. F., Jones, E., Lowe, R. C., Meneely, G. R., Peacock, W.: The relative absorption and utilization of ferrous and ferric iron in anemia as determined with the radioactive isotope. Amer. J. Physiol. 143, 191 (1945).

    CAS  Google Scholar 

  • Hahn, P. F. et al.: Iron metabolism in human pregnancy as studied with the radioactive isotope Fe59. Amer. J. Obstet. Gynec. 61, 477 (1951).

    PubMed  CAS  Google Scholar 

  • Halkett, J. A. E., Chodos, R. B., Ross, J. F.: The labeling of human foods with radioactive iron (Fe59). J. Lab. clin, Med. 53, 816 (1959).

    CAS  Google Scholar 

  • Halkett, J. A. E., Peters, T. Jr., Ross, J. F.: Studies on the deposition and nature of egg yolk iron. J. biol. Chem. 231, 187 (1958).

    PubMed  CAS  Google Scholar 

  • Hallberg, L.: Die Eisenresorption — einige neuere physiologische und therapeutische Erkenntnisse. In: Keiderling, W., Hoffmann, G. (eds.): Radioisotope in der Hämatologie. Schattauer, Stuttgart 1963.

    Google Scholar 

  • Hallberg, L., Bjorn Rasmussen, E.: Determination of iron absorption from whole diet. A new two-pool model using two radioiron isotopes given as haem and non-haem iron. Scand. J. Haemat. 9, 193 (1972).

    PubMed  CAS  Google Scholar 

  • Hallberg, L. et al.: Absorption from iron tablets given with different types of meals. Scand. J. Haemat. 21, 215 (1978).

    PubMed  CAS  Google Scholar 

  • Hallberg, L., Sölvell, L.: Absorption of a single dose of iron in man. Acta med. scand. 168 (Suppl. 358), 19 (1960a).

    CAS  Google Scholar 

  • Hallberg, L., Sölvell, L.: Iron absorption during constant intragastric infusion of iron in man. Acta med. scand. 168 (Suppl. 358), 43 (1960b).

    CAS  Google Scholar 

  • Hegsted, D. M., Finch, C. A., Kinney, T. D.: The influence of diet on iron absorption. J. exp. Med. 90, 147 (1949),

    PubMed  CAS  Google Scholar 

  • Hegsted, D. M., Finch, C. A., Kinney, T. D.: The influence of diet on iron absorption. J. exp. Med. 96, 115(1952).

    PubMed  CAS  Google Scholar 

  • Heilmeyer, L.: Blut und Blutkrankheiten. 5th ed., Part 1. Springer, Berlin-Heidelberg-New York 1968.

    Google Scholar 

  • Heilmeyer, L., Begemann, H.: Blut und Blutkrankheiten. Springer, Berlin-Göttingen-Heidelberg 1951.

    Google Scholar 

  • Heilmeyer, L., Keiderling, W., Wöhler, F.: Existiert bei der Eisenresorption im Dünndarm ein Mucosablock? Klin. Wschr. 35, 690 (1957).

    PubMed  CAS  Google Scholar 

  • Heinrich, H. C.: Bestimmung und Normalbereich der bei hämatologischen Erkrankungen gemessenen Eisenresorption bei Verwendung des Fe59-Resorptions-Gesamtkörper-Retentionstestes. 12. Tagung der Deutschen Gesellschaft für Hämatologie, Berlin 1966.

    Google Scholar 

  • Herbut, P. A., Tamaki, H. T.: Cirrhosis of liver and diabetes as related to hemochromatosis. Amer. J. clin. Path. 16, 640 (1964).

    Google Scholar 

  • Hobbs, J. R.: Iron deficiency after partial gastrectomy. Gut 2, 141 (1961).

    PubMed  CAS  Google Scholar 

  • Howard, J., Jacobs, A.: Iron transport by rat small intestine in vitro: effect of body iron status. Brit. J. Haemat. 23, 595 (1972).

    PubMed  CAS  Google Scholar 

  • Hwang, Y. F., Brown, G. B.: Effect of desferrioxamine on iron absorption. Lancet 1, 135 (1965).

    PubMed  CAS  Google Scholar 

  • Iwao, T., Kurihara, M.: Microchemical investigation of iron absorbed from intestinal canal. Tr. Soc. path. Jap. 23, 196 (1933).

    Google Scholar 

  • Jacobi, H., Pfleger, R., Rummel, W.: Komplexbildner und aktiver Eisentransport durch die Darmwand. Arch. exp. Path. Pharmak. 229, 198 (1956).

    CAS  Google Scholar 

  • Jacobs, A.: The mechanism of iron absorption. In: Callender, S. T. (ed.): Clinics in Haematology, Vol. 2/2, pp. 323–337. Saunders, London-Philadelphia-Toronto 1973.

    Google Scholar 

  • Jacobs, A., Miles, P. M.: Intraluminal transport of iron from stomach to small intestinal mucosa. Brit. med. J. iv, 778 (1969a).

    Google Scholar 

  • Jacobs, A., Miles, P. M.: The iron binding properties of gastric juice. Clin. chim. Acta 24, 87 (1969b).

    PubMed  CAS  Google Scholar 

  • Jacobs, A., Worwood, M.: Ferritin in serum. New Engl. J. Med. 292, 951 (1975a).

    PubMed  CAS  Google Scholar 

  • Jacobs, A., Worwood, M.: Iron absorption: present state of the art. Brit. J. Haemat. Suppl. 31, 89 (1975b).

    Google Scholar 

  • Jacobs, P., Bothwell, T. H., Charlton, R. W.: Role of hydrochloric acid in iron absorption. J. appl. Physiol. 19, 187 (1964).

    PubMed  CAS  Google Scholar 

  • Jacobs, P., Bothwell, T. H., Charlton, R. W.: Intestinal iron transport; studies using a loop of gut with an artificial circulation. Amer. J. Physiol. 210, 694 (1966).

    PubMed  CAS  Google Scholar 

  • Jasinski, B., Roth, O.: Die larvierte Eisenmangelkrankheit. Schwabe, Basel 1954.

    Google Scholar 

  • Johnston, F. A., Clark, S. J.: Reduction of ferric iron to the ferrous form during digestion in vitro with saliva. Amer. J. clin. Nutr. 7, 203 (1959).

    PubMed  CAS  Google Scholar 

  • Josephs, H. W.: Absorption of iron as a problem in human physiology. Blood 13, 1 (1958).

    PubMed  CAS  Google Scholar 

  • Kaufman, N., Klavins, J. V., Kinney, T. D.: Excessive iron absorption in rats fed low-protein, high-fat diets. Lab. Invest. 7, 369 (1958).

    PubMed  CAS  Google Scholar 

  • Kavin, H., Charlton, R. W., Jacobs, P.: Effect of the exocrine pancreatic secretions on iron absorption. Gut 8, 556 (1967).

    PubMed  CAS  Google Scholar 

  • Kinney, T. D., Kaufman, N., Klavins, J. V.: Effect of ethionine-induced pancreatic damage on iron absorption. J. exp. Med. 102, 151 (1955).

    PubMed  CAS  Google Scholar 

  • Krantz, S., Goldwasser, E., Jacobson, L. O.: Studies on erythropoiesis. XIV. The relationship of humoral stimulation to iron absorption. Blood 14, 654 (1959).

    PubMed  CAS  Google Scholar 

  • Kuhn, I. N., Monsen, E. R., Cook, J. D., Finch, C. A.: Iron absorption in man. J. Lab. clin. Med. 71, 715 (1968).

    PubMed  CAS  Google Scholar 

  • Layrisse, M., Cook, J. D., Martinez-Torres, C., Roche, M., Kuhn, I. N., Walker, R. B., Finch, C. A.: Food iron absorption: a comparison of vegetable and animal foods. Blood 33, 430 (1969).

    PubMed  CAS  Google Scholar 

  • Layrisse, M., Martinez-Torres, C.: Model for measuring the dietary absorption from heme iron. Test with a complete meal. Amer. J. clin. Nutr. 25, 401 (1972).

    PubMed  CAS  Google Scholar 

  • Levine, P. H., Levine, A. J., Weintraub, L. R.: The role of transferrin in the control of iron absorption: studies on a cellular level. J. Lab. clin. Med. 80, 333 (1972).

    PubMed  CAS  Google Scholar 

  • Luke, C. G., Davis, P. A., Deller, D. J.: Change in gastric iron binding protein (gastroferrin) during iron deficiency anaemia. Lancet 1, 926 (1967).

    PubMed  CAS  Google Scholar 

  • Manis, J., Schachter, D.: Active transport of iron by the intestine: mucosal iron pools. Amer. J. Physiol. 207, 893 (1964).

    PubMed  CAS  Google Scholar 

  • Martinez-Torres, C., Layrisse, M.: Effect of amino acids on iron absorption from a staple vegetable food. Blood 35, 669 (1970).

    PubMed  CAS  Google Scholar 

  • Mazur, A., Green, S., Saha, A., Carleton, A.: Mechanism of release of ferritin iron in vivo by xanthine oxidase. J. clin. Invest. 37, 1809 (1958).

    PubMed  CAS  Google Scholar 

  • Milder, M. S., Cook, J. D., Finch, C. A.: Influence of food iron absorption on plasma iron level in idiopathic hemochromatosis. Acta haemat. 60, 65 (1978).

    PubMed  CAS  Google Scholar 

  • Millar, J. A., Goldberg, A., Cumming, R. L. C.: Studies on ferritin synthesis in relation to iron absorption. In: Hallberg, L., Harwerth, H. G., Vannotti, A. (eds.): Iron Deficiency, p. 121. Academic Press, London-New York 1970.

    Google Scholar 

  • Moore, C. V.: The importance of nutritional factors in the pathogenesis of iron deficiency anemia. Amer. J. clin. Nutr. 3, 3 (1955).

    PubMed  CAS  Google Scholar 

  • Moore, C. V., Dubach, R.: Observations on the absorption of iron from foods tagged with radioiron. Trans. Ass. Amer. Physicians 64, 245 (1951).

    PubMed  CAS  Google Scholar 

  • Moore, C. V., Dubach, R., Minnich, V., Roberts, H. K.: Absorption of ferrous and ferric radioactive iron by human subjects and by dogs. J. clin. Invest. 23, 755 (1944).

    PubMed  CAS  Google Scholar 

  • Murray, M. J., Stein, N.: Does the pancreas influence iron absorption? A critical review of information to date. Gastroenterology 51, 694 (1966).

    PubMed  CAS  Google Scholar 

  • Norrby, A., Sölvell, L.: Effect of dietary iron on iron absorption in man. Scand. J. Haemat. 9, 396 (1972).

    PubMed  CAS  Google Scholar 

  • Pinkerton, P. H.: The control of iron absorption by the intestinal epithelial cell. Ann. intern. Med. 70, 401 (1969).

    PubMed  CAS  Google Scholar 

  • Pirzio-Biroli, G., Finch, C. A.: Iron absorption. III. The influence of iron stores on iron absorption in the normal subject. J. Lab. clin. Med. 55, 216 (1960).

    PubMed  CAS  Google Scholar 

  • Pirzio-Biroli, G., Bothwell, T. H., Finch, C. A.: Iron absorption. II. The absorption of radioiron administered with a standard meal in man. J. Lab. clin. Med. 51, 37 (1958).

    PubMed  CAS  Google Scholar 

  • Reynafarje, C., Lozano, R., Valdivieso, J.: The polycythemia of high altitudes. Iron metabolism and related aspects. Blood 14, 433 (1959).

    PubMed  CAS  Google Scholar 

  • Rieber, E. E., Conrad, M. E., Crosby, W. H.: Gastrectomy and iron absorption. Effects of bleeding, iron loading and ascorbic acid in rats. Proc. Soc. exp. Biol. (N. Y.) 124, 577 (1967).

    CAS  Google Scholar 

  • Rudzki, Z., Deller, D. J.: The iron-binding glycoprotein of human gastric juice. I. Isolation and characterisation. Digestion (Basel) 8, 31 (1973).

    Google Scholar 

  • Saylor, L., Finch, C. A.: Determination of iron absorption using two isotopes of iron. Amer. J. Physiol. 172, 372 (1953).

    PubMed  CAS  Google Scholar 

  • Schulz, J., Smith, N. J.: A quantitative study of the absorption of iron salts in infants and children. Amer. J. Dis. Child. 95, 120 (1958).

    CAS  Google Scholar 

  • Smith, J. A., Drysdale, J. W., Munro, H. N., Goldberg, A.: The effect of enteral and parenteral iron on the synthesis of ferritin in the intestinal mucosa of the rat. Brit. J. Haemat. 14, 79 (1968).

    PubMed  CAS  Google Scholar 

  • Smith, M. D., Pannacciulli, I. M.: Absorption of inorganic iron from graded doses; its significance in relation to iron absorption tests and the mucosal block theory. Brit. J. Haemat. 4, 428 (1958).

    PubMed  CAS  Google Scholar 

  • Smith, P. M., Studley, F., Williams, R.: Postulated gastric factor enhancing iron absorption in haemochromatosis. Brit. J. Haemat. 16, 443 (1969).

    PubMed  CAS  Google Scholar 

  • Sobel, H. D., Waye, J. D.: Pancreatic changes in various types of cirrhosis in alcoholics. Gastroenterology 45, 341 (1963).

    PubMed  CAS  Google Scholar 

  • Sölvell, L.: Effect of iron and transferrin intravenously on iron absorption and turnover in man. Acta med. scand. 168 (Suppl. 358), 71 (1960).

    Google Scholar 

  • Stevens, A. R., Pirzio-Biroli, G., Harkins, H. N., Nyhus, L. M., Finch, C. A.: Iron metabolism in patients after partial gastrectomy. Ann. Surg. 149, 534 (1959).

    PubMed  CAS  Google Scholar 

  • Stewart, W. B., Vassar, P. S., Stone, R. S.: Iron absorption in dogs during anemia due to acetylphenylhydrazine. J. clin. Invest. 32, 1225 (1953).

    PubMed  CAS  Google Scholar 

  • Stewart, W. B., Yuile, C. L., Claiborne, H. A., Snowman, R. T., Whipple, G. H.: Radioiron absorption in anemic dogs. Fluctuations in the mucosal block and evidence for a gradient of absorption in the gastrointestinal tract. J. Exp. Med. 92, 375 (1950).

    PubMed  CAS  Google Scholar 

  • Strohmeyer, G.: Messung der Körperradioaktivität zur Bestimmung der Eisenresorption beim Menschen. In: Keiderling, W., Hoffmann, G. (eds.): Radioisotope in der Hämatologie, p. 69. Schattauer, Stuttgart 1963.

    Google Scholar 

  • Taylor, J., Stiven, D., Reid, E. W.: Haemochromatosis in a depancreatized cat. J. Path. Bact. 34, 793 (1931).

    CAS  Google Scholar 

  • Taylor, J., Stiven, D., Reid, E. W.: Experimental and idiopathic siderosis in cats. J. Path. Bact. 41, 397 (1935).

    CAS  Google Scholar 

  • Turnberg, L. A.: Iron absorption in acute hepatitis. Amer. J. dig. Dis. 11, 20 (1966).

    PubMed  CAS  Google Scholar 

  • Turnbull, A.s: The absorption of radioiron given with a standard meal after Pólya partial gastrectomy. Clin. Sci. 28, 499 (1965).

    PubMed  CAS  Google Scholar 

  • Turnbull, A., Finch, C. A. (1961), cit. Bothwell, Finch, 1962.

    Google Scholar 

  • Turnbull, A., Cleton, F., Finch, C. A.s: Iron absorption. IV. The absorption of hemoglobin iron. J. clin. Invest. 41, 1897 (1962).

    PubMed  CAS  Google Scholar 

  • van Dyke, D., Layrisse, M., Lawrence, J. H., Garcia, J. F., Pollycove, M.: Relation between severity of anemia and erythropoietin titre in human beings. Blood 18, 187 (1961).

    Google Scholar 

  • van Hoek, R., Conrad, M. E., Jr.: Iron absorption. Measurement of ingested iron59 by a human whole body liquid scintillation counter. J. clin. Invest. 40, 1153 (1961).

    CAS  Google Scholar 

  • Wack, J. P., Wyatt, J. P.: Studies on ferrodynamics. I. Gastrointestinal absorption of Fe59 in the rat under differing dietary states. Arch. Path. 67, 237 (1959).

    CAS  Google Scholar 

  • Walters, G. O., Jacobs, A., Worwood, M., Trevett, D.: Iron absorption in normal subjects and patients with idiopathic haemochromatosis: relationship with serum ferritin concentration. Gut 16, 188 (1975).

    PubMed  CAS  Google Scholar 

  • Weinfeld, A.: Iron stores. In: Hallberg, L., Harwerth, H. G., Vannotti, A. (eds.): Iron Deficiency. Academic Press, London-New York 1970.

    Google Scholar 

  • Weintraub, L. R., Weinstein, M. B., Huser, H. J., Rafel, S.: Absorption of hemoglobin iron; the role of a heme-splitting substance in the intestinal mucosa. J. clin. Invest. 47, 531 (1968).

    PubMed  CAS  Google Scholar 

  • Whitehead, J. S. W., Bannerman, R. M.: Absorption of iron by gastrectomized rats. Gut 5, 38 (1964).

    PubMed  CAS  Google Scholar 

  • Wöhler, F., Heilmeyer, L., Emrich, D., Kang, S. H.: Zur Funktion des Ferritins bei der Eisenresorption. Arch. exp. Path. Pharmakol. 230, 107 (1957).

    Google Scholar 

  • Wynter, C. V. A., Williams, R.: Iron binding properties of gastric juice in idiopathic haemochromatosis. Lancet 2, 534 (1968a).

    PubMed  CAS  Google Scholar 

  • Wynter, C. V. A., Williams, R.: Gastric iron binding in haemochromatosis. Lancet 2, 1243 (1968b).

    Google Scholar 

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Authors
  1. Iván Bernát M.D., D.Sc.
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© 1983 Akadémiai Kiadó, Budapest

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Bernát, I. (1983). Iron Absorption. In: Iron Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7308-1_6

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  • DOI: https://doi.org/10.1007/978-1-4615-7308-1_6

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