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Protein-Deficiency Anemia

  • Iván Bernát

Abstract

Protein malnutrition results in a moderate anemia. Studies in children with kwashiorkor (Coward and Whitehead, 1972) have shown that the hemoglobin concentration does not fall until there is actual body wasting. The role of pure protein deficiency is difficult to determine in the human subject because it is likely to be associated with other nutritional deficiencies, e.g., folic acid, iron, vitamin B12. A study in Vietnam (Le Xuan Chat et al., 1971), involving pregnant women, nonpregnant women, and men, showed a deficiency of iron, B12, and folic acid in 40%, a dual deficiency in 20%, and an isolated deficiency of one of the substances in 24%, the major cause of the deficiencies being an inadequate diet and/or chronic parasitic infection rather than pregnancy. Because of these complications, pure protein-deficiency anemia is probably better studied in the experimental animal.

Keywords

Folic Acid Iron Metabolism Protein Deficiency Session Paper Moderate Anemia 
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Bibliography

  1. Adams, E. B., Scragg, J. N., Naidoo, B. T., Liljestrand, S. K., Kockram, V. I.: Observations on the aetiology and treatment of anaemia in kwashiorkor. Brit. med. J. 3, 451 (1967).PubMedCrossRefGoogle Scholar
  2. Aschkenasy, A.: Études sur la production d’érythropoietine chez le rat carence en protéines. Rev.franç. Étud. clin. biol. 8, 985 (1963).PubMedGoogle Scholar
  3. Chou, A. C. et al.: Abnormalities of iron metabolism and erythropoiesis in vitamin E-deficient rabbits. Blood 52, 187(1978).Google Scholar
  4. Coward, W., Whitehead, R. G.: Changes in haemoglobin concentrations during the development of kwashiorkor. Brit. J. Nutr. 28, 463 (1972).PubMedCrossRefGoogle Scholar
  5. Donati, R. M., Chapman, C. V., Warnecke, M. A., Galagher, N. I.: Iron metabolism in acute starvation. Proc. Soc. exp. Biol. Med. 117, 50 (1964).PubMedGoogle Scholar
  6. Finch, C. A.: Protein deficiency and anemia. Plenary Session Papers. Xllth Congr. Internat. Soc. Hematol., New York 1968.Google Scholar
  7. Ghitis, J., Piazuelo, E., Vitale, J. J.: Cali-Harvard nutrition project. III. The erythroid atrophy of protein deficiency in monkeys. Amer. J. clin. Nutr. 12, 452 (1963).PubMedGoogle Scholar
  8. Ghitis, J., Velez, H., Linares, F., Sinisterra, L., Vitale, J. J.: Cali-Harvard nutrition project. II. The erythroid atrophy of kwashiorkor and marasmus. Amer. J. clin. Nutr. 12, 445 (1963).PubMedGoogle Scholar
  9. Heath, C. V., Taylor, F. H. L.: The nitrogen metabolism in anemia during the regeneration of blood. J. clin. Invest. 75, 411 (1936).CrossRefGoogle Scholar
  10. Ito, K., Reissman, K. R.: Quantitative and qualitative aspect of steady state erythropoiesis induced in protein-starved rats by long-term erythropoietin injection. Blood 27, 343 (1966).PubMedGoogle Scholar
  11. Le Xuan Chat, Le Xuan Anh, Bun Mat et al.: Nutritional anemias in Vietnam. Rev.franç. Hémat. 11, 807 (1971).Google Scholar
  12. Orten, J. M., Orten, A. U.: The production of polycythemia by cobalt in rats made anemic by a diet low in protein. Amer. J. Physiol. 144, 464 (1945).Google Scholar
  13. Pearson, P. B., Elvehjem, C. A., Hart, E. B.: The relation of protein to hemoglobin building. J. biol. Chem. 119, 749 (1937).Google Scholar
  14. Reissman, K. R.: Protein metabolism and erythropoiesis. II. Blood 23, 146 (1964).Google Scholar
  15. Robsheit-Robbins, F. S., Madden, S. C., Rowe, A. P., Turner, A. P., Whipple, G. W.: Hemoglobin and plasma protein. Simultaneous production during continued bleeding as influenced by diet low in protein and other factors. J. exp. Med. 72, 479 (1940).CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest 1983

Authors and Affiliations

  • Iván Bernát

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