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Ion Channels pp 283–327Cite as

Ionic Channels in Ocular Epithelia

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Abstract

Membrane phenomena are dominated by channels, integral membrane proteins specialized to allow and control the movement of solutes through aqueous pores spanning the membrane. The tiny aqueous pore (less than 1 nm in diameter) is embedded in a much larger protein cylinder some 10 nm in diameter and length that shields the solute from the low dielectric constant of the lipid membrane, decreasing the electrostatic energy barriers which prevent ion movement across artificial lipid membranes. Proteins play a role in membrane phenomena (whether the proteins form “channels” or other transporters) akin to the role of enzymes in metabolism: they accelerate the rate of chemical reactions or solute translocation so greatly that, to a good approximation, they are the only pathways of biological significance.

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Author information

Authors and Affiliations

  1. Departments of Physiology and Biophysics and Ophthalmology, Mayo Foundation, Rochester, Minnesota, 55905, USA

    J. L. Rae

  2. Department of Physiology, Rush Medical College, Chicago, Illinois, 60612, USA

    R. A. Levis & R. S. Eisenberg

Authors
  1. J. L. Rae
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  2. R. A. Levis
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  3. R. S. Eisenberg
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Editor information

Editors and Affiliations

  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

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© 1988 Plenum Press, New York

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Rae, J.L., Levis, R.A., Eisenberg, R.S. (1988). Ionic Channels in Ocular Epithelia. In: Narahashi, T. (eds) Ion Channels. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7302-9_8

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  • DOI: https://doi.org/10.1007/978-1-4615-7302-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7304-3

  • Online ISBN: 978-1-4615-7302-9

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