Abstract
Cellular immunity in insects is mediated by blood cells, or hemocytes, which eliminate invading foreign organisms by phagocytosis and encapsulation (Salt, 1963, 1970; Poinar, 1969, 1974; Whitcomb et al., 1974; Nappi, 1974, 1975a). Encapsulation reactions are typically characterized by the aggregation and adhesion of hemocytes forming multilayered capsules which melanize around foreign surfaces too large to be engulfed by a single host cell. Although many significant contributions have been made to the study of insect immunity, important questions concerning the mechanism of hemocyte activation and the specificity of cellular interactions with various infectious and oncogenic agents still remain unanswered. An elementary understanding of how immuno-competent cells differentiate between ‘self’ and ‘not-self’ and react to eliminate foreignness necessitates a working knowledge of the origin and diverse functions of specific cell types, and of the mechanisms which regulate their activity throughout development and under various pathological conditions. Unfortunately, little of this information is available for insects, and only for a very few species.
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References
Bairati, A., Jr., and M. E. Perotti (1966). Electron microscope studies of the ultrastructure of melanotic tumors in Drosophila melanogaster. In “Atti V. Congr. It. Microscopy Elettron.” pp. 42–45. Tipogr. Seminario, Padova.
Casarett, G. W. (1963). Concept and criteria of radiologic aging. In “Cellular Basis and Aetiology of Late Somatic Effects of Ionizing Radiation.” (R.J.C. Harris, ed.), pp. 189–205. Academic Press, New York.
Castiglioni, M. C. (1957). Le cellule dell’emolinfa di Drosophila melanogaster in relazione al genotipo e alla produzione di pseudotumori. Atti III Riun. Assoc. Genet. Ital. La Ric. Sci., suppl., 27, 51–57.
Gateff, E., and H. A. Schneiderman (1969). Neoplasms in mutant and cultured wild-type tissues of Drosophila. Nat. Cancer Inst. Monogr., 31, 365–397.
Gateff, E., and H. A. Schneiderman (1974). Developmental capacities of benign and malignant neoplasms of Drosophila. Wilhelm Roux’ Archiv., 176, 23–65.
Ghelelovitch, S. (1969). Melanotic tumors in Drosophila melanogaster. Nat. Cancer Inst. Monogr., 31, 263–275.
Good, R. A., and J. Finstad (1969). Essential relationship between the lymphoid system, immunity, and malignancy. Nat. Cancer Inst. Monogr., 31, 41–58.
Götz, P. (1969). Die Einkapselung von Parasiten in der Hamolymphe von Chironomus-Larven (Diptera). Zool. Anz., Suppl., 33, 610–617.
Götz, P., and A. Vey (1974). Humoral encapsulation in Diptera (Insecta): defence reactions of Chironomus larvae against fungi. Parasitology, 68.
Harshbarger, J. C. (1974). Radiation, neoplasms, carcinogenic chemicals, and insects. In “Insect Diseases.” (G. E. Cantwell, ed.), Vol. 2, pp. 377–416. Marcel Dekker, Inc. New York.
Harshbarger, J. C., and R. L. Taylor (1968). Neoplasms of insects. Ann. Rev. Ent., 13, 159–190.
Hauri, H. (1974). Ein invasives Neoplasms aus embryonalen Zellen von Drosophila melanogaster in Dauerkultur in vivo. J. Embryol. Exp. Morph., 31, 347–375.
Miquel, J., K. G. Bensch, D. E. Philpott, and H. Atlan (1972). Natural aging and radiation-induced life shortning in Drosophila melanogaster. Mech. Age. Dev., 1, 71–97.
Miquel, J., A. L. Tappel, C. J. Dillard, M. M. Herman, and K. G. Bensch (1974). Fluorescent products and lysosomal components in aging Drosophila melanogaster. J. Gerontol., 6, 622–637.
Nappi, A. J. (1974). Insect hemocytes and the problem of host recognition of foreignness. In “Contemporary Topics in Immunobiology.” (E. L. Cooper, ed.), Vol. 4, pp. 207–224. Plenum Press, New York.
Nappi, A. J. (1975a). Parasite encapsulation in insects. In “Invertebrate Immunity. Mechanisms of Invertebrate Vector-Parasite Relations.” (K. Maramorosch and R. E. Shope, eds.), pp. 293–326. Academic Press, New York.
Nappi, A. J. (1975b). Cellular immune reactions of larvae of Drosophila algonquin. Parasitology, 70, 189–194.
Nappi, A. J. (1975c). Inhibition by parasites of melanotic tumor formation in Drosophila melanogaster. Nature, 255, 404–404.
Nappi, A. J., and F. A. Streams (1969). Haemocytic reactions of Drosophila melanogaster to the parasites Pseudeucoila mellipes and P. bochei. J. Insect Physiol., 15, 1551–1566.
Oftedal, P. (1953). The histogenesis of a new tumor in Drosophila melanogaster, and a comparison with tumors of five other stocks. Z. Indukt. Abstammungs. Vererbungsl., 85, 408–422.
Perotti, M. E. and A. Bairati, Jr. (1968). Ultrastructure of the melanotic masses in two tumorous strains of Drosophila melanogaster (tuB 3 and Freckled). J. Invertebr. Pathol., 10, 122–138.
Poinar, G. O., Jr. (1969). Arthropod immunity to worms. In “Immunity to Parasitic Animals.” (G. J. Jackson, R. Herman, and I. Singer, eds.), Vol. 1, pp. 173–210. Appleton-Centnry-Crofts, New York.
Poinar, G. O., Jr. (1974). Insect immunity to parasitic nematodes. In “Contemporary Topics in Immunobiology.” (E. L. Cooper, ed.), Vol. 4, pp. 167–178. Plenum Press, New York.
Poinar, G. O., Jr., and R. Leutennegger (1971). Ultrastructural investigations of the melanization process in Culex pipiens (Culicidae) in response to a parasitic nematode (Mermithidae). J. Ultrastruct. Res., 36, 149–158.
Poinar, G. O., Jr., R. Leutenegger, and P. Götz (1968). Ultrastructure of the formation of a melanotic capsule in Diabrotica (Coleoptera) in response to a parasitic namatode (Mermithidae). J. Ultrastruct. Res., 25, 293–306.
Rizki, T. M. (1957). Tumor formation in relation to metamorphosis in Drosophila melanogaster. J. Morph., 100, 459–472.
Rizki, T. M. (1960). Melanotic tumor formation in Drosophila. J. Morph., 106, 147–157.
Rizki, T. M., and R. M. Rizki (1959). Functional significance of the crystal cells in the larva of Drosophila melanogaster. J. Biophys. Cytol., 5, 235–240.
Rizki, T. M., and R. M. Rizki (1974a). Topology of the caudal fat body of the tumorw mutant of Drosophila melanogaster. J. Invertebr. Pathol., 24, 37–40.
Rizki, T. M., and R. M. Rizki (1974b). Basement membrane abnormalities in melanotic tumor formation of Drosophila. Experientia, 30., 543–546.
Salt, G. (1963). The defense reactions of insects to metazoan parasites. Parasitology, 53, 527–642.
Salt, G. (1970). “The Cellular Defense Reactions of Insects.” Cambridge University Press, London. Scharrer, B. and M. S. Lochhead. Tumors in the invertebrates; A review. Cancer Res., 10, 403–419.
Stark, M. B. (1918). An hereditary tumor in the fruit fly, Drosophita. J. Cancer Res., 3, 279–301.
Stark, M. B. (1919). A benign tumor that is hereditary in Drosophita. Proa. Nat. Acad. Soi., 5, 578–580.
Vinson, S. B., and J. R. Scott (1974). Parasitoid egg shell changes in a suitable and unsuitable host. J. Uttrastruct. Res., 47, 1–15.
Walker, I. (1959). Die Abwehrreaktion des Wirtes Drosophita metanogaster gegen die zoophage Cynipidae Pseudeucoita bochei Weld. Rev. Suisse Zoot., 68, 569–632.
Whitcomb, R. F., M. Shapiro, and R. R. Granados (1974). Insect defense mechanisms against microorganisms and parasitoids. In “The Physiology of Insecta.” (M. Rockstein, ed.) Vol. 5. Academic Press, New York.
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Nappi, A.J. (1977). Comparative Ultrastructural Studies of Cellular Immune Reactions and Tumorigenesis in Drosophila . In: Bulla, L.A., Cheng, T.C. (eds) Comparative Pathobiology. Comparative Pathobiology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7299-2_9
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