Toxicity to the Immune System: A Review

  • Jack H. Dean
  • Joel B. Cornacoff
  • Michael I. Luster


Immunotoxicology is defined as the study of events that lead to undesired effects as a result of interaction of foreign substances (e.g., xenobiotics) with the immune system. Toxic responses might arise when the immune system either (1) acts as a passive target of chemical insult, leading to a relatively broad-spectrum loss or potentiation of function; or (2) responds to the antigenic specificity of the chemical as part of a specific immune response. In the latter instance, a more limited population of antigen-specific immune cells is the initial target of the chemical interaction, with the potential for toxic responses to occur (e.g., in the skin or lungs), subsequent to the specific interaction between the chemical antigen (hapten) and host antibody or sensitized cells.


Polycyclic Aromatic Hydrocarbon Alveolar Macrophage Host Resistance Organotin Compound Estramustine Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





cell-mediated immunity

Con A

con- canavalin A


cyclosporin A


cytotoxic T lymphocyte




di-n-butyltin dichloride




di-n-octyltin dichloride


delayed-type hypersensitivity


enzyme-linked immunosorbent assay


graft versus host


humoral mediated immunity




interleukin 1


interleukin 2




mixed leukocyte response


maximum tolerated dose NK, natural killer (cell)


polybrominated biphenyls


plasma cell


polychorinated biphenyls


plaque-forming cell




prostaglandin E2


sheep red blood cell




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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jack H. Dean
    • 1
  • Joel B. Cornacoff
    • 1
  • Michael I. Luster
    • 2
  1. 1.Sterling Research GroupRensselaerUSA
  2. 2.National Toxicology Programs, National Institute of Environmental Health ScienceResearch Triangle ParkUSA

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