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Toxicity to the Immune System: A Review

  • Jack H. Dean
  • Joel B. Cornacoff
  • Michael I. Luster

Abstract

Immunotoxicology is defined as the study of events that lead to undesired effects as a result of interaction of foreign substances (e.g., xenobiotics) with the immune system. Toxic responses might arise when the immune system either (1) acts as a passive target of chemical insult, leading to a relatively broad-spectrum loss or potentiation of function; or (2) responds to the antigenic specificity of the chemical as part of a specific immune response. In the latter instance, a more limited population of antigen-specific immune cells is the initial target of the chemical interaction, with the potential for toxic responses to occur (e.g., in the skin or lungs), subsequent to the specific interaction between the chemical antigen (hapten) and host antibody or sensitized cells.

Keywords

Polycyclic Aromatic Hydrocarbon Alveolar Macrophage Host Resistance Organotin Compound Estramustine Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AB

antibody

CMI

cell-mediated immunity

Con A

con- canavalin A

CSA

cyclosporin A

CTL

cytotoxic T lymphocyte

CY

cyclophosphamide

DBCT

di-n-butyltin dichloride

DES

diethylstilbestrol

DOTC

di-n-octyltin dichloride

DTH

delayed-type hypersensitivity

ELISA

enzyme-linked immunosorbent assay

GVH

graft versus host

HMI

humoral mediated immunity

Ig

immunoglobulin

IL-1

interleukin 1

IL-2

interleukin 2

Mϕ

macrophage

MLR

mixed leukocyte response

MTD

maximum tolerated dose NK, natural killer (cell)

PBB

polybrominated biphenyls

PC

plasma cell

PCB

polychorinated biphenyls

PFC

plaque-forming cell

PG

prostaglandin

PGE2

prostaglandin E2

SRBC

sheep red blood cell

TCDD

2,3,7,8-tetrachlorodibenzo-p-dioxin.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jack H. Dean
    • 1
  • Joel B. Cornacoff
    • 1
  • Michael I. Luster
    • 2
  1. 1.Sterling Research GroupRensselaerUSA
  2. 2.National Toxicology Programs, National Institute of Environmental Health ScienceResearch Triangle ParkUSA

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