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Cyclic Nucleotides, Arachidonic Acid, and Polyamines in the Pathophysiology of Inflammatory Proliferative Skin Diseases

  • John J. Voorhees
Part of the Comprehensive Immunology book series (COMIMUN, volume 7)

Abstract

Psoriasis is a multifactorial genetic disease (Watson et al., 1972) in which a major feature is an exaggerated epidermal proliferation. Various disorders in immunodermatology such as allergic contact dermatitis and atopic dermatitis have increases of normal epithelial proliferation as a major feature of the lesion. At least at the level of current understanding, there is reason to assume that many of the described abnormal mechanisms in psoriatic epithelium will also be present in hyperplastic epidermis in general. This chapter will cover mechanisms of proliferation, using psoriasis as a model, with the idea that the knowledge may well pertain to epidermis stimulated to proliferate by immune injury.

Keywords

Arachidonic Acid Cyclic Nucleotide Psoriatic Lesion Free Arachidonic Acid Psoriatic Epidermis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • John J. Voorhees
    • 1
  1. 1.Department of DermatologyUniversity of Michigan Medical SchoolAnn ArborUSA

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