The Complement System

Mechanisms of Action, Biology, and Participation in Dermatological Diseases
  • Irma Gigli
Part of the Comprehensive Immunology book series (COMIMUN, volume 7)


Although it is still not possible to integrate completely the various components involved in the inflammatory response, we now have the capability of indicating some of the effector pathways and identifying a number of points of interaction between them. The effector pathway considered in this chapter is the complement system, an essential part of the normal immune response. It consists of a special group of normal serum proteins which on activation interact sequentially in a process of limited proteolysis with the development of active macromolecules and fragments. Appreciation of this complex system has already provided a better understanding of certain pathological processes, the introduction of new therapeutic approaches, and the development of procedures to evaluate disease activity.


Systemic Lupus Erythematosus Complement System Chronic Urticaria Classical Pathway Human Complement 
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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • Irma Gigli
    • 1
  1. 1.Department of Dermatology and MedicineNew York University Medical Center and Irvington House InstituteNew YorkUSA

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