Immunopathology and Pathogenesis of Cutaneous Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a multisystem disease of unknown etiology. It may be acute and fulminating or slowly progressive, with characteristic exacerbations and remissions. Most investigators agree that the clinical expression of lupus erythematosus forms a spectrum from chronic cutaneous lupus erythematosus (known as discoid LE or DLE) to the often fatal, multisystem LE with nephritis. In studying this clinical spectrum, we have examined clinical and serological data from several distinct subsets of patients with LE. These studies indicate that LE may be viewed not only in a spectrum, or continuum, from a clinicopathological standpoint, but also in a related spectrum of immunological responses. An understanding of these clinical, serological, and immunopathological relationships is helpful in the diagnosis and management of these patients and provides insight into the pathogenesis of the disease.
KeywordsSystemic Lupus Erythematosus Skin Lesion Systemic Lupus Erythematosus Patient Cutaneous Lupus Erythematosus Follow Bone Marrow Transplantation
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