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Eosinophil in Skin Disorders

  • Dorothea Zucker-Franklin
Part of the Comprehensive Immunology book series (COMIMUN, volume 7)

Abstract

Eosinophils have received increasing attention from dermatologists over the years as the association of eosinophilia with several skin diseases has become more generally realized. Described as early as 1879, eosinophils have since proved to be associated with allergic, parasitic, and neoplastic disorders. Dermatologists were among the first physicians to recognize the importance of this association; patients with cutaneous disease occasionally show highly increased numbers of eosinophils, either in inflammatory infiltrates or in the circulation or both.

Keywords

Atopic Dermatitis Eosinophil Count Mycosis Fungoides Schistosoma Mansoni Aryl Sulfatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alexander, J. D., 1961, Is eosinophilia of diagnostic importance in dermatitis herpetiforms? Br. J. Dermatol. 73: 267–272.PubMedCrossRefGoogle Scholar
  2. Allen, A. C., 1948, Persistent “insect bites” (dermal eosinophilic granulomas) simulating lymphoblastomas, histiocytoses, and squamous cell carcinomas, Am. J. Pathol. 24: 367–387.PubMedGoogle Scholar
  3. Archer, R. K., 1960, Eosinophil leukocyte attracting effect of histamine in skin, Nature 187: 155–156.PubMedCrossRefGoogle Scholar
  4. Atkins, P., Green, G. R., and Zweiman, B., 1973, Influx of eosinophils as consequence of IgE dependent reactions, J. Allergy Clin. Immunol. 51: 263–273.PubMedCrossRefGoogle Scholar
  5. Baehner, R., and Johnston, R. B., 1971, Metabolic and bactericidal activities of human eosinophils, Br. J. Haematol. 20: 277–285.PubMedCrossRefGoogle Scholar
  6. Basten, A., and Beeson, P. B., 1970, Mechanisms of eosinophilia. II. Role of the lymphocyte, J. Exp. Med. 131: 1288–1305.PubMedCrossRefGoogle Scholar
  7. Basten, A., Boyer, M. H., and Beeson, P. B., 1970, Mechanism of eosinophilia. I. Factors affecting the eosinophil response of rats to Trichinella spiralis, J. Exp. Med. 131: 1271–1287.PubMedCrossRefGoogle Scholar
  8. Beeson, P. B., and Bass, D. A., 1977, The Eosinophil, Vol. 14, Philadelphia, Saunders, New York.Google Scholar
  9. Boyer, M. H., Basten, A., and Beeson, P. B., 1970, Mechanism of eosinophilia. III. Suppression of eosinophilia by agents known to modify immune responses, Blood 36: 458–469.PubMedGoogle Scholar
  10. Butterworth, A. E., Sturrock, R. F., Houba, V., Mah-moud, A. A. F., Sher, A., and Rees, P. H., 1975, Eosinophils as mediators of antibody-dependent damage to schistosomula, Nature (London) 256: 727–729.CrossRefGoogle Scholar
  11. Butterworth, A. E., David, J. R., Franks, D., Mahmoud, A. A. F., David, P. H., Sturrock, R. F., and Houba, V., 1977, Antibody-dependent eosinophil-mediated damage to 51Cr-labelled schistosomula of Schistosoma man-soni: Damage by purified eosinophils, J. Exp. Med. 145: 136–150.PubMedCrossRefGoogle Scholar
  12. Clark, R. A. F., Gatlin, J. I., and Kaplan, A. P., 1975, The selective eosinophil chemotactic activity of histamine, J. Exp. Med. 142:1462–1476.Google Scholar
  13. Colley, D. G., 1973, Eosinophils and immune mechanisms. I. Eosinophil stimulation promotor (ESP): A lymphokine induced by specific antigen or phytohemagglutinin, J. Immunol. 110:1419–1423.Google Scholar
  14. Colley, D. G., 1975, Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni, J. Immunol. 115: 150–156.PubMedGoogle Scholar
  15. Dale, D. C., Hubert, R., and Fauci, A. S., 1976, Eosinophil kinetics in the hypereosinophil syndrome, J. Lab. Clin. Med. 87: 487–495.Google Scholar
  16. Eidinger, D., Wilkinson, R., and Rose, B., 1964, A study of cellular responses in immune reactions utilizing the skin window technique, J. Allergy 35: 77–85.PubMedCrossRefGoogle Scholar
  17. El-Hashimi, W., 1971, Charcot-Leyden crystals—Formation from primate and lack of formation from nonprimate eosinophils, Am. J. Pathol. 65: 311–324.PubMedGoogle Scholar
  18. Faller, A., 1966, Zur Frage von Struktur und Aufbau der Eosinophilen Granula, Z. Zellforsch. Mikrosk. Anat. 69: 551–565.PubMedCrossRefGoogle Scholar
  19. Feinberg, A. R., Feinberg, S. M., and Lee, F., 1967, Leukocytes and hypersensitivity reactions: Eosinophil response in skin windows to ragweed extracts, histamine and compound 48/80 in atopic and non-atopic individuals, J. Allergy 40: 73–87.PubMedCrossRefGoogle Scholar
  20. Gleich, G. J., Loegering, D. A., and Maldonado, J. E., 1973, Identification of a major basic protein in guinea pig eosinophil granules, J. Exp. Med. 137:1459–1471.Google Scholar
  21. Gleich, G. J., Loegering, D. A., Mann, K. G., and Maldonado, J. E., 1976, Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils, J. Clin. Invest. 57: 633640.Google Scholar
  22. Goetzl, E. J., Wasserman, S. I., and Austen, K. F., 1974, Modulation of the Eosinophil Chemotactic Response in Immediate Hypersensitivity, (L. Brent and J. Holborow, eds.), pp. 41–50, North-Holland, Amsterdam.Google Scholar
  23. Gross, R., 1962, The eosinophils, in: The Physiology and Pathology of Leukocytes (H. Braunsteiner and D. Zucker-Franklin, eds.), pp. 1–46, Grune and Stratton, New York.Google Scholar
  24. Higashi, G. I., and Chowdhury, A. B., 1970, In vitro adhesion of eosinophils to infective larvae of Wuchereria bancrofti, Immunology 19: 65–83.PubMedGoogle Scholar
  25. Hubscher, T., 1975, Role of the eosinophil in the allergic reactions. I. EDI—An eosinophil-derived inhibitor of histamine release, J. Immunol. 114: 1379–1388.PubMedGoogle Scholar
  26. Kay, A. B., and Austen, K. F., 1971, The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung, J. Immunol. 107: 889–902.Google Scholar
  27. Kay, A. B., Stechschulte, D. J., and Austen, K. F., 1971, An eosinophil leukocyte chemotactic factor of anaphylaxis, J. Exp. Med. 133: 602–619.PubMedCrossRefGoogle Scholar
  28. Klebanoff, S. J., Durack, D. T., Rosen, H., and Clark, R. A., 1977, Functional studies on human peritoneal eosinophils, Infect. Immun. 17: 167–173.PubMedGoogle Scholar
  29. Mahmoud, A. A. F., Warren, K. S., and Peters, P. A., 1975, A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum, J. Exp. Med. 142: 805–813.PubMedCrossRefGoogle Scholar
  30. O’Loughlin, S., Diaz-Perez, J. L., Gleich, G. J., and Winkelmann, R. K., 1977, Serum IgE in dermatitis and dermatosis: An analysis of 497 cases, Arch. Dermatol. 113: 309.PubMedCrossRefGoogle Scholar
  31. Olsson, I., PerVenge, Spitznagel, J. K., and Lehrer, R. I., 1977, Arginine-rich cationic proteins of human eosinophil granules, Lab. Invest. 36: 493–500.PubMedGoogle Scholar
  32. Parish, W. E., 1972, Eosinophilia. II. Cutaneous eosinophilia in guinea pigs mediated by passive anaphylaxis with IgGI or reagin, and antigen-antibody complexes; its relation to neutrophils and to mast cells, Immunology 23: 19–34.PubMedGoogle Scholar
  33. Pinkus, H., 1951, Granulomas with eosinophilia (“eosinophilic granulomas”), Med. Clin. North Am. 35: 463479.Google Scholar
  34. Schaefer, H. E., Hubner, G., and Fischer, R., 1973, Spezifische Microgranula in Eosinophilen, Acta Haematol. 50: 92–104.PubMedCrossRefGoogle Scholar
  35. Stenger, R. J., Warren, K. S., and Johnson, E. A., 1967, An ultrastructural study of hepatic granulomas and schistosome egg shells in murine hepatosplenic Schistosomiasis mansoni, Exp. Mol. Pathol. 7: 116–132.PubMedCrossRefGoogle Scholar
  36. Taliaferro, W. H., and Sarles, M. P., 1939, The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris, J. Infect. Dis. 54: 157–192.CrossRefGoogle Scholar
  37. Tanaka, K. R., Valentine, W. N., and Fredricks, R. E., 1962, Human leukocyte aryl sulphatase activity, Br. J. Haematol. 8: 86–92.PubMedCrossRefGoogle Scholar
  38. Vercauteren, R., 1953, The properties of the isolate gran- ules from blood eosinophils, Enzymologia 16: 1–13.PubMedGoogle Scholar
  39. Von Lichtenberg, F., Sher, A., Gibbons, N., and Doughty, B. L., 1976, Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni, Am. J. Pathol. 84: 479492.Google Scholar
  40. Ward, J. M., Wright, J. F., and Wharran, G. H., 1972, Ultrastructure of granulocytes in the peripheral blood of the cat. J. Ultrastruct. Res. 39:389–3%.Google Scholar
  41. Wasserman, S. I., Goetz!, E. J., and Austen, K. F., 1975, Inactivation of slow reacting substance of anaphylaxis of human eosinophil arylsufatase, J. Immunol. 114: 645649.Google Scholar
  42. Welsh, R. A., 1959, The genesis of the Charcot-Leyden crystal in the eosinophilic leukocyte of man, Am. J. Pathol. 35: 1091–1103.PubMedGoogle Scholar
  43. Zucker-Franklin, D., 1974, Eosinophil function and disor-ders, Adv. Int. Med. 19:1–25.Google Scholar
  44. Zucker-Franklin, D., 1978, The properties of eosinophils, in: Immediate Hypersensitivity: Modern Concepts and Developments ( M. K. Back, ed.), pp. 407–430, Dekker, New York.Google Scholar
  45. Zucker-Franklin, D., and Hirsch, J. G., 1964, Electron microscope studies on the degranulation of rabbit peritoneal leukocytes during phagocytosis, J. Exp. Med. 120: 569–575.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • Dorothea Zucker-Franklin
    • 1
  1. 1.Department of MedicineNew York University Medical CenterNew YorkUSA

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