Cell-Mediated Immunity

  • Susanna Cunningham-Rundles
Part of the Comprehensive Immunology book series (COMIMUN, volume 7)


Two major types of immune response have been described in man. One type is mediated by thymus-derived (T) lymphocytes and is characterized by cellular interactions. The other type is produced by the activities of immunoglobulins secreted by bone marrow (B) lymphocytes when these have differentiated to become plasma cells. Since T-cell immunity requires cellular functions for both development and expression, this type of response has been termed cell-mediated immunity. In contrast, B-cell-associated immune response depends on immunoglobulins carried in the serum and has been called humoral immunity. T-cell immune functions include those effective in host defense against spread of certain infectious agents, contact sensitivity, allograft rejection, and graft-vs.-host disease. B-cell-associated immune responses provide protection against encapsulated bacteria and many viruses, participate in formation of immune complexes, are essential for antibody-mediated cytotoxicity, and affect many aspects of immune reactions through the production of specific antibodies. The ontogeny and development of T and B lymphocytes are described elsewhere. Humoral immunity and the specificity of immunoglobulin production by differentiated B cells are discussed in Chapter 3. In this chapter some characteristic features of cell-mediated immunity will be presented.


Human Lymphocyte Suppressor Cell Lymphocyte Activation Purify Protein Derivative Lymphocyte Response 
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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • Susanna Cunningham-Rundles
    • 1
  1. 1.Clinical Immunology and Tissue Typing LaboratoriesSloan-Kettering Institute for Cancer ResearchNew YorkUSA

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