Skip to main content

Part of the book series: Human Nutrition ((HUNU,volume 3B))

Abstract

Vitamin K is a generic term for a homologous group of fat-soluble vitamins consisting of 2-methyl-1,4-naphthoquinone derivatives. Their absence from the gut of animals and birds causes bleeding due to a coagulation defect of their blood. This coagulation defect is the result of the inadequate synthesis of biologically active prothrombin and certain related vitamin-K-dependent coagulation factors (VII, IX, and X).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aggeler, P. M., Lucia, S. P., and Fishbon, H. M., 1942, Purpura due to vitamin K deficiency in anorexia nervosa, Am. J. Dig. Dis. 9: 227.

    Google Scholar 

  • Almquist, H. J., and Klose, A. A., 1939a, The antihemorrhagic activity of pure synthetic phthiocol, J. Am. Chem. Soc. 61: 1611.

    CAS  Google Scholar 

  • Almquist, H. J., and Klose, A. A., 1939b, Determination of the antihemorrhagic vitamin, Biochem. J. 33: 1055.

    CAS  Google Scholar 

  • Almquist, H. J., and Stokstad, E. L. R., 1936, Factors influencing incidence of dietary hemorrhagic disease in chicks, J. Nutr. 12: 329.

    CAS  Google Scholar 

  • Andrus, W. D. E. W., Lord, J. W., Jr., and Moore, R. A., 1939, The effect of hepatectomy on the plasma prothrombin and the utilization of vitamin K, Surgery 6: 899.

    Google Scholar 

  • Ansbacher, S., 1941, The bioassay of vitamin K, J. Nutr. 21: 1.

    CAS  Google Scholar 

  • Ansbacher, S., and Fernholz, E., 1939, Simple compounds with vitamin K activity, J. Am. Chem. Soc. 61: 1924.

    CAS  Google Scholar 

  • Babson, A. L., Malament, S., Mangun, G. H., and Phillips, G. E., 1956, The effect of simultaneous administration of vitamin K and dicumarol on the prothrombin in rat plasma, Clin. Chem. 2: 243.

    Google Scholar 

  • Bell, R. G., and Matschiner, J. T., 1969, Intracellular distribution of vitamin K in the rat, Biochim. Biophys. Acta 184: 597.

    CAS  Google Scholar 

  • Biggs, R. P., and McFarlane, R. G., 1962, Human Blood Coagulation and Its Disorders, F. A. Davis, Philadelphia.

    Google Scholar 

  • Billeter, M., and Martius, C., 1960, Über die Umwandlung von Phyllochinon (Vitamin K,) in Vitamin K2 im Tierkörper, Biochem. Z. 333: 430.

    CAS  Google Scholar 

  • Billeter, M., Bolliger, W., and Martius, C., 1964, Untersuchungen über die Umwandlung von verfütterten K-Vitaminen durch Austausch der Seitenkette und die Rolle der Darmbakterien hierbei, Biochem. Z. 340: 290.

    CAS  Google Scholar 

  • Binkley, S. B., Cheney, L. C., Holcomb, W. F., McKee, R. W., Thayer, S. A., MacCorquodale, D. W., and Doisy, E. A., 1939a, The constitution and synthesis of vitamin K1, J. Am. Chem. Soc. 61: 2558.

    CAS  Google Scholar 

  • Binkley, S. B., MacCorquodale, D. W., Thayer, S. A., and Doisy, E. A., 1939b, Isolation of vitamin K1, J. Biol. Chem. 130: 219.

    CAS  Google Scholar 

  • Binkley, S. B., McKee, R. W., Thayer, S. A., and Doisy, E. A., 1940, The constitution of vitamin K2, J. Biol. Chem. 133: 721.

    CAS  Google Scholar 

  • Blomstrand, R., and Forsgren, L., 1968, Labelled tocopherols in man. Intestinal absorption and thoracic-duct lymph transport of d/-alpha-tocopheryl-3,4-“C2 acetate, d/-alpha tocopheramine-3,4–14C2, dl-alpha-tocopherol-(5 methyl-3H) and N-(methyl-3H)-d/-gamma-tocopheramine, Int. J. Vitam. Nutr. Res. 38: 45.

    CAS  Google Scholar 

  • Brinkhous, K. M., 1940, Plasma prothrombin; vitamin K, Medicine 19: 329.

    CAS  Google Scholar 

  • Brinkhous, K. M., Smith, H. P., and Warner, E. D., 1937, Plasma prothrombin level in normal infancy and in hemorrhagic disease of newborn, Am. J. Med. Sci. 193: 475.

    Google Scholar 

  • Campbell, H. A., Smith, W. K., Roberts, W. L., and Link, K. P., 1941, The bioassay of hemorrhagic concentrates by following the prothrombin level in the plasma of rabbit blood, J. Biol. Chem. 138: 1.

    CAS  Google Scholar 

  • Carmack, M., Moore, M. B., and Balis, M. B., 1950, The structure of the antihemorrhagic sodium bisulfite addition product of 2-methyl-1,4-naphthoquinone (menadione), J. Am. Chem. Soc. 72: 844.

    CAS  Google Scholar 

  • Carter, J. R., and Warner, E. D., 1958, Correction of defects in clotting accelerator activity by administration of methionine and vitamin K and of a new sulfhydryl-substituted methylnaphthoquinone, vitamin K-S(II), J. Clin. Invest. 37: 70.

    CAS  Google Scholar 

  • Clark, R. L., Dixon, C. F., Butt, H. R., and Snell, A. M., 1939, Deficiency of prothrombin associated with various intestinal disorders: Its treatment with the antihemorrhagic vitamin (vitamin K), Mayo Clin. Proc. 14: 407.

    CAS  Google Scholar 

  • Dam, H., 1929, Cholesterinstoffwechsel in Hühnereiern and Hühnchen, Biochem. Z. 215: 475.

    Google Scholar 

  • Dam, H., 1966, Historical survey and introduction, Vitam. Horm. (N.Y.) 24: 295.

    CAS  Google Scholar 

  • Dam, H., and Glavind, J., 1938, Determination of vitamin K by the curative blood-clotting method, Biochem. J. 32: 1018.

    CAS  Google Scholar 

  • Dam, H., SchOnheyder, F., and Tage-Hansen, E., 1936, CLV. Studies on the mode of action of vitamin K, Biochem. J. 30: 1075.

    CAS  Google Scholar 

  • Dam, H., Gerger, A., Glavind, J., Karrer, P., Karrer, W., Rothschild, E., and Salomon, H., 1939a, Isolierung des Vitamins K in hochgereinigter Form, He/v. Chim. Acta 22: 310.

    CAS  Google Scholar 

  • Dam, H., Tage-Hansen, E., and Plum, P., 1939b, Vitamin K lack in normal and sick infants, Lancet 237: 1157.

    Google Scholar 

  • Dann, F. P., 1939, Quantitative biological assays of vitamin K and its application to several quinone compounds, Proc. Soc. Exp. Biol. Med. 42: 663.

    CAS  Google Scholar 

  • Davie, E. W., and Ratnoff, O. D., 1964, Waterfall sequence for intrinsic blood clotting, Science 145: 1310.

    CAS  Google Scholar 

  • Dialameh, G. H., Yekundi, K. G., and Olson, R. E., 1970, Enzymatic alkylation of menaquinone- 0 to menaquinones by microsomes from chick liver, Biochim. Biophys. Acta 223: 332.

    CAS  Google Scholar 

  • Dialameh, G. H., Taggart, W. V., Matschiner, J. T., and Olson, R. E., 1971, Isolation and characterization of menaquinone-4 as a product of menadione metabolism in chicks and rats, Int. J. Vitam. Nutr. Res. 41: 391.

    CAS  Google Scholar 

  • Doisy, E. A., Jr., and Matschiner, J. T., 1970, Fat-soluble vitamins, in: International Encyclopedia of Food and Nutrition, Vol. 9 ( R. A. Martin, ed.), pp. 293–332, Pergamon Press, Oxford.

    Google Scholar 

  • Doisy, E. A., MacCorquodale, D. W., Thayer, S. A., Brinkley, S. B., and McKee, R. W., 1939, The isolation and synthesis of vitamin K1, Science 90: 407.

    Google Scholar 

  • Douglas, A. S., and Brown, A., 1952, Effect of vitamin K preparations on hypoprothrombinaemia induced by dicoumarol and tromexan, Br. Med. J. 1: 412.

    CAS  Google Scholar 

  • Dyggve, H. V., Sondergaard, E., and Dam, H., 1962, Effect of synkavit and vikastab on bilirubin and plasma prothrombin, Acta Paediatr. (Stockholm) 51: 165.

    CAS  Google Scholar 

  • Esmon, C. T., and Suttie, J. W., 1976, Vitamin K-dependent carboxylase. Solubilization and properties, J. Biol. Chem. 251: 6238.

    CAS  Google Scholar 

  • Esmon, C. T., Sadowski, J. A., and Suttie, J. W., 1975, A new carboxylation reaction, J. Biol. Chem. 250: 4744.

    CAS  Google Scholar 

  • Fieser, L. F., 1940, Convenient procedures for the preparation of antihemorrhagic compounds, J. Biol. Chem. 133: 91.

    Google Scholar 

  • Fieser, L. F., and Fry, E. M., 1940, Water-soluble antihemorrhagic esters, J. Am. Chem. Soc. 62: 228.

    CAS  Google Scholar 

  • Fieser, L. F., and Turner, R. B., 1947, The addition of sulfhydryl derivatives to 2-methyl-1,4naphthoquinone, J. Am. Chem. Soc. 69: 2335.

    CAS  Google Scholar 

  • Fieser, L. F., Tishler, M., and Sampson, W. L., 1940, Naphthoquinone oxides, J. Am. Chem. Soc. 62: 1628.

    CAS  Google Scholar 

  • Filmer, D. L, and Cooper, T. G., 1970, Effect of varying temperature and pH upon the predicted rate of “CO2” utilization by carboxylases, J. Theor. Biol. 29: 131.

    CAS  Google Scholar 

  • Foster, R. H. K., Lee, J., and Solmssen, U. V., 1940, Sodium salt of 2-methyl-1,4-naphthohydroquinone diphosphoric acid ester, J. Am. Chem. Soc. 62: 453.

    CAS  Google Scholar 

  • Fourie, D. T., and Hay, I. T., 1975, Warfarin as a possible teratogen, S. Afr. Med. J. 49: 2081.

    CAS  Google Scholar 

  • Frick, P. G., Riedler, G., and Brögli, 1967, Dose response and minimal daily requirement for vitamin K in man, J. Appl. Physiol. 23: 387.

    CAS  Google Scholar 

  • Friedman, P. A., and Shia, M. A., 1977, The apparent absence of involvement of biotin in the vitamin K-dependent carboxylation of glutamic acid residues of proteins, Biochem. J. 163: 39.

    CAS  Google Scholar 

  • Gale, P. H., Arison, B. H., Trenner, N. R., Page, A. C., and Folkers, K., 1963, Coenzyme Q. 36. Isolation and characterization of coenzyme Q10(H-10), Biochemistry 2: 196.

    CAS  Google Scholar 

  • Girardot, J. M., Delaney, R., and Johnson, B. C., 1976, Carboxylation, the completion step in prothrombin biosynthesis, Biochem. Biophys. Res. Commun. 59: 1197.

    Google Scholar 

  • Greaves, J. H., and Ayers, P., 1967, Heritable resistance to warfarin in rats, Nature 215: 877.

    Google Scholar 

  • Gustafsson, B. E., Daft, F. S., McDaniel, E. G., Smith, J. C., and Fitzgerald, R. M., 1962, Effects of vitamin K-active compounds and intestinal microorganisms in vitamin K-deficient germ-free rats, J. Nutr. 78: 461.

    CAS  Google Scholar 

  • Hauschka, P. V., Lian, J. B., and Gallop, P. M., 1975, Direct identification of the calcium-binding amino acid, y-carboxyglutamate, in mineralized tissue, Proc. Natl. Acad. Sci. U.S.A. 72: 3925.

    CAS  Google Scholar 

  • Hauschka, P. V., Friedman, P. A., Traverso, H. P., and Gallop, P. M., 1976, Vitamin K-dependent y-carboxyglutamic acid formation by kidney microsomes in vitro, Biochem. Biophys. Res. Commun. 71: 1207.

    CAS  Google Scholar 

  • Hermodson, M. A., Suttie, J. W., and Link, K. P., 1969, Warfarin metabolism and vitamin K requirement in the warfarin-resistant rat, Am. J. Physiol. 217: 1316.

    CAS  Google Scholar 

  • Hougie, C., Barrow, E. M., and Graham, J. B., 1957, Stuart clotting defect, I. Segregation of an hereditary hemorrhagic state from the heterogeneous group heretofore called “stable factor” (SPCA, proconvertin, factor VII) deficiency, J. Clin. Invest. 36: 485.

    CAS  Google Scholar 

  • Houser, R. M., Carey, D. J., Dus, K. M., Marshall, G. R., and Olson, R. E., 1977, Partial sequence of rat prothrombin and the activity of two related pentapeptides as substrates for the vitamin K-dependent carboxylase system, FEBS Lett. 75: 226.

    CAS  Google Scholar 

  • Irrevere, F., and Sullivan, M. X., 1941, A colorimetric test for vitamin K,, Science 94: 497.

    Google Scholar 

  • Isler, O., 1959, Über die Vitamine K, and K2, Angew. Chem. 71: 7.

    CAS  Google Scholar 

  • Isler, O., and Wiss, O., 1959, Chemistry and biochemistry of the K vitamins, Vitam. Horm. (N. Y.) 17: 53.

    CAS  Google Scholar 

  • Isler, O., Ruegg, R., Chopard-dit-Jean, L. H., Winterstein, A., and Wiss, O., 1958, Synthese und Isolierung von Vitamin K2 und Isoprenologen Verbindungen, Hely. Chim. Acta 41: 786.

    CAS  Google Scholar 

  • IUNS Commission on Nomenclature, 1971, Tentative rules for generic descriptors, J. Nutr. 101: 134.

    Google Scholar 

  • IUNS Commission on Nomenclature, 1977, Nomenclature policy: Generic descriptors and trivial names for vitamins and related compounds, J. Nutr. 107: 7.

    Google Scholar 

  • IUPAC-IUB Commission on Biochemical Nomenclature, 1966, Tentative rules, J. Biol Chem. 241: 2987.

    Google Scholar 

  • Jones, J. P., Gardner, E. J., Cooper, T. G., and Olson, R. E., 1977, Vitamin K-dependent carboxylation of peptide-bound glutamate. The active species of “CO2” utilized by the membrane-bound preprothrombin carboxylase, J. Biol. Chem. 252: 7738.

    CAS  Google Scholar 

  • Kark, R., and Lozner, E. L., 1939, Nutritional deficiency of vitamin K in man: Study of 4 non-jaundiced patients with dietary deficiency, Lancet 2: 1162.

    Google Scholar 

  • Lian, J. B., and Prien, E. L. Jr., 1976, y-Carboxyglutamic acid in the calcium binding matrix of certain kidney stones, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 1763.

    Google Scholar 

  • Lorusso, D. J., and Suttie, J. W., 1972, Warfarin binding to microsomes isolated from normal and warfarin-resistant rat liver, Mol. Pharmacol. 8: 197.

    CAS  Google Scholar 

  • Losito, R., Owen, C. A., Jr., and Flock, E. V., 1967, Metabolism of [14C]menadione,Biochemistry 6: 62.

    CAS  Google Scholar 

  • Mack, D. O., Suen, E. T., Girardot, J. M., Miller, J. A., Delaney, R., and Johnson, B. C., 1976, Soluble enzyme system for vitamin K-dependent carboxylation, J. Biol. Chem. 251: 3269.

    CAS  Google Scholar 

  • Magnusson, S., Sottrup-Jansen, L., and Peterson, T. E., 1974, Primary structure of the vitamin K-dependent part of prothrombin, FEBS Lett. 44: 189.

    CAS  Google Scholar 

  • Mameesh, M. S., and Johnson, B. C., 1960, Dietary vitamin K1 requirement of the rat, Proc. Soc. Exp. Biol. Med. 103: 378.

    CAS  Google Scholar 

  • Mann, J. D., Mann, F. D., and Bollman, J. L., 1949, Hypoprothrombinemia due to loss of intestinal lymph, Am. J. Physiol. 158: 311.

    CAS  Google Scholar 

  • Martius, C., 1966, Mode of action of vitamin K in animals, Vitam. Horm. (N.Y.) 24: 441.

    CAS  Google Scholar 

  • Martius, C., and Esser, H. O., 1958, Uber die Konstitution des im Tierkörper aus Methylnaphthochinon gebildeten K-Vitamines, Biochem. Z. 331: 1.

    CAS  Google Scholar 

  • Matschiner, J. T., and Amelotti, J. M., 1968, Characterization of vitamin K from bovine liver, J. Lipid Res. 9: 176.

    CAS  Google Scholar 

  • Matschiner, J. T., and Doisy, E. A., Jr., 1966, Bioassay of vitamin K in chicks, J. Nutr. 90: 97.

    CAS  Google Scholar 

  • Matschiner, J. T., and Taggart, W. V., 1968, Bioassay of vitamin K by intracardial injection in deficient adult male rats, J. Nutr. 94: 57.

    CAS  Google Scholar 

  • Matschiner, J. T., Hsia, S. L., and Doisy, E. A., Jr., 1967a, Effect of indigestible oils in vitamin K deficiency in the rat, J. Nutr. 91: 299.

    CAS  Google Scholar 

  • Matschiner, J. T., Taggard, W. V., and Amelotti, J. M., 1967b, The vitamin K content of beef liver. Detection of a new form of vitamin K, Biochemistry 6: 1243.

    CAS  Google Scholar 

  • Matschiner, J. T., Bell, R. G., Amelotti, J. M., and Knauer, T. E., 1970, Isolation and characterization of a new metabolite of phylloquinone in the rat, Biochim. Biophys. Acta 201: 309.

    CAS  Google Scholar 

  • McFarlane, W. D., Graham, W. R., and Richardson, F., 1939, Fat soluble vitamin requirements in the chick, Biochem. J. 25: 358.

    Google Scholar 

  • McKee, R. W., Binkley, S. B., Thayer, S. A., MacCorquodale, D. W., and Doisy, E. A., 1939, Isolation of vitamin K2, J. Biol. Chem. 131: 327.

    CAS  Google Scholar 

  • Mezick, J. A., Settlemire, C. T., Brierley, G. P., Barefield, K. P., Jenson, W. N., and Cornwell, D. G., 1970, Erythrocyte membrane interactions with menadione and the mechanism of menadione-induced hemolysis, Biochim. Biophys. Acta 219: 361.

    CAS  Google Scholar 

  • Moore, M. B., 1941, The antihemorrhagic activity of sulfonated derivatives of 2-methylnaphthalene, J. Am. Chem. Soc. 63: 2049.

    CAS  Google Scholar 

  • Munns, T. W., Johnston, M. F. M., Liszewski, M. K., and Olson, R. E., 1976, Vitamin K-dependent synthesis and modification of precursor prothrombin in cultured H-35 hepatoma cells, Proc. Natl. Acad. Sci. U.S.A. 73: 2803.

    CAS  Google Scholar 

  • Naeye, R. L., 1956, Plasma thromboplastin component: Influence of coumarin compounds and vitamin K on its activity in serum, Proc. Soc. Exp. Biol. Med. 91: 101.

    CAS  Google Scholar 

  • Nelsestuen, G. L., Zytkovicz, T. H., and Howard, J. B., 1974, The mode of action of vitamin K, J. Biol. Chem. 249: 6347.

    CAS  Google Scholar 

  • Nelson, T. S., and Norris, L. C., 1960, Studies on the vitamin K requirement of the chick. I. Requirements of the chick for vitamin K1, menadione and menadione sodium bisulfite, J. Nutr. 72: 137.

    CAS  Google Scholar 

  • Nelson, T. S., and Norris, L. C., 1961, Studies on the vitamin K requirement of the chick, Poult. Sci. 40: 392.

    CAS  Google Scholar 

  • Olson, R. E., 1974, New concepts relating to the mode of action of vitamin K, Vitam. Horm. (N. Y.) 32: 483.

    CAS  Google Scholar 

  • Olson, R. E., and Suttie, J. W., 1977, Vitamin K and y-carboxyglutamate biosynthesis, Vitam. Horm. (N.Y.) 35: 59.

    CAS  Google Scholar 

  • Olson, R. E., Philipps, G., and Wang, N.-T., 1968, The regulatory action of vitamin K, Adv. Enzyme. Regul. 6: 213.

    CAS  Google Scholar 

  • Olson, R. E., Houser, R. M., Searcey, M. T., Gardner, E. J., Scheinbuks, J., Subba Rao, G. N., Jones, J. P. and Hall, A. L., 1978, Nature of vitamin K-dependent CO2 fixation in microsomal membranes, Fed. Proc. Fed. Am. Soc. Exp. Biol. 37: 2610–2614.

    CAS  Google Scholar 

  • O’Reilly, R. A., and Aggeler, P. M., 1970, Determinants of the response to oral anticoagulant drug in man, Pharmacol. Rev. 22: 35.

    Google Scholar 

  • O’Reilly, R. A., Aggeler, P. M., Hoag, M. S., Leong, L. S., and Kropatkin, M. L., 1964, Hereditary transmission of exceptional resistance to coumarin anticoagulant drugs, N. Engl. J. Med. 271: 809.

    Google Scholar 

  • Owen, C. A., 1947, Experimental alteration of the rate of thrombin formation during blood clotting, Bull. Am. Coll. Surg. 32: 256.

    Google Scholar 

  • Pennock, J. F., 1966, Occurrence of vitamins K and related quinones, Vitam. Horm. (N.Y.) 24: 307.

    CAS  Google Scholar 

  • Pettifor, J. M., and Benson, R., 1975, Congenital malformations associated with the administration of oral anticoagulants during pregnancy, J. Pediatr. 86: 459.

    CAS  Google Scholar 

  • Pool, J. G., O’Reilly, R. A., Schneiderman, L. J., and Alexander, M., 1968, Warfarin resistance in the rat, Am. J. Phvsiol. 215: 627.

    CAS  Google Scholar 

  • Potter, E. L., 1945, The effect on infant mortality of vitamin K administered during labor, Am. J. Obstet. Gynecol. 50: 235.

    Google Scholar 

  • Price, P. A., Otsuka, A. S., Poser, J. W., Kirstaponis, J., and Raman, N., 1976a, Characterization of a y-carboxyglutamic acid containing protein from bone, Proc. Natl. Acad. Sci. U.S.A. 73: 1447.

    CAS  Google Scholar 

  • Price, P. A., Poser, J. W., and Raman, N., 1976b, Primary structure of the y-carboxyglutamic acid-containing protein from bovine liver, Proc. Natl. Acad. Sci. U.S.A. 73: 3374.

    CAS  Google Scholar 

  • Quick, A. J., and Collentine, G., 1950, The role of vitamin K in the formation of prothrombin, J. Lab. Clin. Med. 36: 976.

    CAS  Google Scholar 

  • Richardson, L. R., Wilkes, S., and Ritchey, S. J., 1961, Comparative vitamin Be activity of frozen, irradiated and heat-processed foods, J. Nutr. 73: 363.

    CAS  Google Scholar 

  • Rietz, P., Gloor, U., and Wiss, O., 1970, Menachionone aus menschlicher Leber and Faulschlamm, Int. J. Vitam. Nutr. Res. 40: 351.

    CAS  Google Scholar 

  • Roderick, L. M., 1931, A problem in the coagulation of the blood “sweet clover” disease of cattle, Am. J. Physiol. 96: 413.

    CAS  Google Scholar 

  • Sadowski, J. A., Schnoes, H. K., and Suttie, J. W., 1977, Vitamin K epoxidase: Properties and relationship to prothrombin synthesis, Biochemistry 16: 3856.

    CAS  Google Scholar 

  • Schofield, F. W., 1922, A brief account of a diseased cattle simulating hemorrhagic septicemia due to feeding sweet clover, Can. Vet. Rec. 3: 74.

    Google Scholar 

  • Scholes, P. B., and King, H. K., 1965, Isolation of a naphthaquinone with partly hydrogenated side chain from Corynebacterium diphtherial, Biochem. J. 97: 766.

    CAS  Google Scholar 

  • Schönheyder, F., 1936, The quantitative determination of vitamin K, Biochem. J. 30: 890.

    Google Scholar 

  • Searcey, M. T., Graves, C. B., and Olson, R. E., 1977, Isolation of a warfarin-binding protein from liver reticulum of Sprague-Dawley and warfarin resistant rats, J. Biol. Chem. 252: 6260.

    CAS  Google Scholar 

  • Shah, D. V., and Suttie, J. W., 1974, The vitamin K dependent, in vitro production of prothrombin, Biochem. Biophys. Res. Commun. 60: 1397.

    CAS  Google Scholar 

  • Shaul, W. L., Emery, H., and Hall, J. G., 1975, Chondroplasia punctata and maternal warfarin use during pregnancy, Am. J. Dis. Child. 129: 360.

    CAS  Google Scholar 

  • Shearer, M. J., Barkhan, P., and Webster, G. R., 1970, Absorption and excretion of an oral dose of tritiated vitamin K in man, Br. J. Haematol. 18: 297.

    CAS  Google Scholar 

  • Simon, E. J., Gross, C. S., and Milhorat, A. T., 1956, The metabolism of vitamin E. I. The absorption and excretion of d-a-tocopherol-5-methyl-C14-succinate, J. Biol. Chem. 221: 797.

    CAS  Google Scholar 

  • Stenflo, J., Fernlund, P., Egan, W., and Roepstorff, P., 1974, Vitamin K dependent modifications of glutamic acid residues in prothrombin, Proc. Natl. Acad. Sci. U.S.A. 71: 2730.

    CAS  Google Scholar 

  • Suttie, J. W., 1974, Metabolism and properties of a liver precursor to prothrombin, Vitam. Horm. (N.Y.) 32: 463.

    CAS  Google Scholar 

  • Suttie, J. W., Hageman, J. M., Lehrman, S. R., and Rich, O. H., 1976, Vitamin K-dependent carboxylase. Development of a peptide substrate, J. Biol. Chem. 251: 5827.

    CAS  Google Scholar 

  • Taggart, W. V., and Matschiner, J. T., 1969, Metabolism of menadione-6,7–3M in the rat, Biochemistry 8: 1141.

    CAS  Google Scholar 

  • Thayer, S. A., McKee, R. W., Binkley, S. B., MacCorquodale, D., and Doisy, E. A., 1931, Assay of vitamin K concentrates, Proc. Soc. Exp. Biol. Med. 40: 478.

    Google Scholar 

  • Thierry, M. J., Hermodson, M. A., and Suttie, J. W., 1970, Vitamin K and warfarin distribution and metabolism in the warfarin resistant rat, Am. J. Physiol. 291: 854.

    Google Scholar 

  • Udall, J. A., 1965, Human sources and absorption of vitamin K in relation to anticoagulation stability, J. Am. Med. Assoc. 194: 107.

    Google Scholar 

  • Warkany, J., 1975, A warfarin embryopathy, Am. J. Dis. Child. 129: 287.

    CAS  Google Scholar 

  • Webster, A., and Fitzgerald, J. E., 1943, Clinical use of vitamin K in obstetrics, Surg. Clin. North Am. 23: 85.

    CAS  Google Scholar 

  • Wiss, O., and Gloor, H., 1966, Absorption, distribution, storage, and metabolites of vitamin K and related quinones, Vitam. Horm. (N.Y.) 24: 575.

    CAS  Google Scholar 

  • Wiss, O., Weber, F., Ruegg, R., and Isler, O., 1959, Über die biologische Aktivität der Vitamine K1 and K2 und ihrer Isoprenologe, Z. Physiol. Chem. 314: 245.

    CAS  Google Scholar 

  • Wood, H. G., and Utter, M. F., 1965, The role of CO2 fixation in metabolism, in: Essays in Biochemistry ( P. N. Campbell and G. D. Greville, eds.), pp. 1–27, Academic Press, New York.

    Google Scholar 

  • Woolley, D. W., 1947, Recent advances in the study of biological competitions between structurally related compounds, Physiol. Rev. 27: 308.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Olson, R.E. (1980). Vitamin K. In: Alfin-Slater, R.B., Kritchevsky, D. (eds) Nutrition and the Adult. Human Nutrition, vol 3B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7216-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7216-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7218-3

  • Online ISBN: 978-1-4615-7216-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics