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Undernutrition and the Developing Brain

  • Chapter
Alterations of Chemical Equilibrium in the Nervous System

Abstract

The importance of investigating the effects of undernutrition on the developing brain has become more widely recognized in the past few years. Unfortunately, a neurochemical consideration of the problem has scarcely begun. The aim of this chapter is to summarize the present state of knowledge, and an attempt will be made to interest neurochemical readers in the great need which exists for their participation in the debate.

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References

  1. N. S. Scrimshaw and J. E. Gordon, eds. Malnutrition, Learning and Behaviour, M.I.T. Press, Boston (1968).

    Google Scholar 

  2. J. Dobbing, in Applied Neurochemistry (A. N. Davison and J. Dobbing, eds.) Blackwell, Oxford (1968).

    Google Scholar 

  3. M. Winick, Malnutrition and brain development, J. Pediat. 74:661–679 (1969).

    Article  Google Scholar 

  4. J. Cravioto, H. G. Birch, E. R. de Licardie, and L. Rosales, The ecology of infant weight gain in a preindustrial society, Acta Paediat. Scand. 56:71–84 (1967).

    Article  Google Scholar 

  5. J. Dobbing, in Developmental Neurobiology (W. A. Himwich, ed.) Charles C Thomas, Springfield, Ill. (1970).

    Google Scholar 

  6. J. Dobbing, in Malnutrition, Learning and Behavior (N. S. Scrimshaw and J. E. Gordon, eds.) M.I.T. Press, Boston (1968).

    Google Scholar 

  7. P. Mandel, M. Jacob, and L. Mandel, Étude sur le métabolisme des acides nucléiques. I. Action du jeûne protéique prolongé sur les deux acides nucléiques du foie, du rein et du cerveau. Bull. Soc. Chim. Biol. 32:80–78 (1950).

    PubMed  CAS  Google Scholar 

  8. P. Lehr and J. Gayet, Response of the cerebral cortex of the rat to prolonged protein depletion. I. Tissue weight, nitrogen, DNA and proteins, J. Neurochem. 10:169–176 (1963).

    Article  PubMed  CAS  Google Scholar 

  9. P. Lehr and J. Gayet, Response of the cerebral cortex of the rat to prolonged protein depletion. II Free aspartic, glutamic and gamma-aminobutyric acids, J. Neurochem. 13:805–810 (1966).

    Article  PubMed  CAS  Google Scholar 

  10. M. W. Fox, Neuro-behavioral ontogeny: a synthesis of ethological and neurophysiological concepts, Brain Res. 2:3–20 (1966).

    Article  PubMed  CAS  Google Scholar 

  11. J. P. Scott, Comparative psychology and ethology, Amer. Rev. Psychol. 18:1–40 (1967).

    Article  Google Scholar 

  12. M. Winick and A. Noble, Cellular response in rats during malnutrition at various ages, J. Nutr. 89:300–306 (1966).

    PubMed  CAS  Google Scholar 

  13. A. N. Davison and J. Dobbing, in Applied Neurochemistry (A. N. Davison and J. Dobbing, eds.) Blackwell, Oxford (1968).

    Google Scholar 

  14. J. Dobbing and J. Sands, Timing of neuroblast multiplication in developing human brain, Nature, 226:639–640.

    Google Scholar 

  15. J. P. M. Bensted, J. Dobbing, R. S. Morgan, R. T. W. Reid, and G. Payling Wright, Neurological development and myelination in the spinal cord of the chick embryo, J. Embryol. Exp. Morph. 5:428–437 (1957).

    Google Scholar 

  16. L. W. Lapham, Tetraploid DNA content of Purkinje neurons of human cerebellar cortex, Science 159:310–312 (1968).

    Article  PubMed  CAS  Google Scholar 

  17. E. Howard, Reductions in size and total DNA of cerebrum and cerebellum in adult mice after corticosterone treatment in infancy, Exp. Neurol. 22:191–208 (1968).

    Article  PubMed  CAS  Google Scholar 

  18. J. Dobbing and J. Sands, Human brain development measured quantitatively, (in preparation).

    Google Scholar 

  19. J. W. T. Dickerson and J. Dobbing, Prenatal and postnatal growth and development of the central nervous system of the pig, Proc. Roy. Soc. B. 166:384–395 (1967).

    Article  Google Scholar 

  20. J. Dobbing and J. Sands, Growth and development of the brain and spinal cord of the guinea pig, Brain Res. 17:115–123 (1970).

    Article  PubMed  CAS  Google Scholar 

  21. W. J. Culley and R. O. Lineberger, Effect of undernutrition on the size and composition of the rat brain, J. Nutr. 96:375–381 (1968).

    PubMed  CAS  Google Scholar 

  22. J. W. Benton, H. W. Moser, P. R. Dodge, and S. Carr, Modification of the schedule of myelination in the rat by early nutritional deprivation, Pediatrics, 38:801–807 (1966).

    PubMed  CAS  Google Scholar 

  23. J. Dobbing and E. M. Widdowson, The effect of undernutrition and subsequent rehabilitation on myelination of rat brain as measured by its composition, Brain, 88:357–366 (1965).

    Article  PubMed  CAS  Google Scholar 

  24. M. Winick, I. Fish, and P. Rosso, Cellular recovery in rat tissues after a brief period of neonatal malnutrition, J. Nutr. 95:623–626 (1968).

    PubMed  CAS  Google Scholar 

  25. J. W. T. Dickerson and J. Dobbing, Some peculiarities of cerebellar growth, Proc. Roy.Soc. Med. 59:1088 (1966).

    PubMed  CAS  Google Scholar 

  26. H. P. Chase, W. F. B. Lindsley, and D. O’Brien, Undernutrition and cerebellar development, Nature, 221:554–555 (1969).

    Article  PubMed  CAS  Google Scholar 

  27. M. Winick and P. Rosso, The effect of severe early malnutrition on cellular growth of human brain, Pediat. Res. 3:181–184 (1969).

    Article  PubMed  CAS  Google Scholar 

  28. M. A. Fishman, A. L. Prensky, and P. R. Dodge, Low content of cerebral lipids in infants suffering from malnutrition, Nature, 221:552–553 (1969).

    Article  PubMed  CAS  Google Scholar 

  29. E. Howard, D. M. Granoff, and P. Bujnovsky, DNA, RNA, and cholesterol increases in cerebrum and cerebellum during development of human fetus, Brain Res. 14:697–706 (1969).

    Article  PubMed  CAS  Google Scholar 

  30. M. Winick, Changes in nucleic acid and protein content of the human brain during growth, Pediat. Res. 2:352–355 (1968).

    Article  PubMed  CAS  Google Scholar 

  31. J. Dobbing, The entry of cholesterol into rat brain during development, J. Neurochem. 10:739–742.

    Google Scholar 

  32. J. Dobbing and J. Sands, Chronological determination of brain growth (in preparation.)

    Google Scholar 

  33. H. P. Chase, J. Dorsey, and G. M. McKhann, The effect of malnutrition on the synthesis of a myelin lipid, Pediatrics 40:551–560 (1967).

    PubMed  CAS  Google Scholar 

  34. H. P. Chase and D. O’Brien, Effect of excess phenylalanine and of other amino acids on brain development in the infant rat, Pediat. Res. 4:96–102 (1970).

    Article  PubMed  CAS  Google Scholar 

  35. V. Cabak and R. Najdanvic, Effect of undernutrition in early life on physical and mental development, Arch. Dis. Child. 40:532–534 (1965).

    Article  PubMed  CAS  Google Scholar 

  36. J. Cravioto, E. R. de Licardie, and H. G. Birch, Nutrition, growth and neurointe-grative development: an experimental and ecologic study, Pediatrics 38:319–372 (1966).

    Google Scholar 

  37. M. B. Stoch and P. M. Smythe, Does undernutrition during infancy inhibit brain growth and subsequent intellectual development? Arch. Dis. Child. 38:546–552 (1963).

    Article  PubMed  CAS  Google Scholar 

  38. M. B. Stoch and P. M. Smythe, The effect of undernutrition during infancy on subsequent brain growth and intellectual development, South African Med. J. 41:1027–1030 (1967).

    CAS  Google Scholar 

  39. H. A. Guthrie, Severe undernutrition in early infancy and behavior in rehabilitated albino rats, Physiol. Behav. 3:619–623 (1968).

    Article  Google Scholar 

  40. R. H. Barnes, S. R. Cannold, R. R. Zimmerman, H. Simmons, R. B. MacLeod, and L. Krook, Influence of nutritional deprivations in early life on learning behaviour of rats as measured by performance in a water maze, J. Nutr. 89:399–410 (1966).

    PubMed  CAS  Google Scholar 

  41. D. F. Caldwell and J. A. Churchill, Learning ability in the progeny of rats administered a protein-deficient diet during the second half of gestation, Neurology 17:95–99 (1967).

    Article  PubMed  CAS  Google Scholar 

  42. R. H. Barnes, Experimental animal approaches to the study of early malnutrition and mental development, Fed. Proc. 26:144–147.

    Google Scholar 

  43. S. Frankova and R. H. Barnes, Influence of malnutrition in early life on exploratory behavior of rats, J. Nutr. 96:477–484 (1968).

    PubMed  CAS  Google Scholar 

  44. S. Frankova and R. H. Barnes, Effect of malnutrition in early life on avoidance conditioning and behavior of adult rats, J. Nutr. 96:485–493 (1968).

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Child Health, University of Manchester, Manchester, England

    John Dobbing

Authors
  1. John Dobbing
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Editor information

Editors and Affiliations

  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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© 1971 Plenum Press, New York

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Dobbing, J. (1971). Undernutrition and the Developing Brain. In: Lajtha, A. (eds) Alterations of Chemical Equilibrium in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7175-9_9

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  • DOI: https://doi.org/10.1007/978-1-4615-7175-9_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7177-3

  • Online ISBN: 978-1-4615-7175-9

  • eBook Packages: Springer Book Archive

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