Abstract
The concept of a molecular basis for memory is not new, The term engram, generally credited to Semon,(1) here refers to the physicochemical change in the brain which reflects a long-lasting acquired behavioral change. Its existence remains hypothetical, yet many inferences may be drawn from biochemical experiments designed to elucidate one or another aspect of its nature, and such experiments will be emphasized in this chapter. The field is clearly in its infancy. The day a biochemical, electrophysiological, or morphological correlation is indisputably established, we can be sure that the other disciplines will follow in hot pursuit. Such is the interdisciplinary approach to neurobiology!
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Agranoff, B.W. (1971). Memory. In: Lajtha, A. (eds) Alterations of Chemical Equilibrium in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7175-9_6
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