Skip to main content

Aging

  • Chapter

Abstract

The study of the phenomenon of cellular aging is severely limited by the meager amount of basic information available, and nowhere is this more evident than in the area of the neural sciences. The present review is thus a very limited one, and some of the data considered have of necessity been more of developmental than aging significance. For broader information on aging, the reader is referred to the excellent review of Strehler(1) and to a recent symposium volume.(2)

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B. L. Strehler, Time, Cells, and Aging, Academic Press, New York (1962).

    Google Scholar 

  2. Aspects of the Biology of Aging, Symposium of the Society for Experimental Biology, Number XXI, Academic Press, New York (1967).

    Google Scholar 

  3. C. P. Leblond and B. E. Walker, Renewal of cell populations, Physiol. Rev. 36:255–276 (1956).

    PubMed  CAS  Google Scholar 

  4. T. Inukai, On the loss of Purkinje cells, with advancing age, from the cerebellar cortex of the albino rat, J. Comp. Neurol. 30:229 (1919).

    Google Scholar 

  5. H. Kuhlenbeck, Senile changes in the brain of Wistar Institute rats, Anat. Rec. 88:441 (1944).

    Google Scholar 

  6. H. Brody, Organization of the cerebral cortex. III. A study in aging in human cerebral cortex, J. Comp. Neurol. 102:511–556 (1955).

    Article  PubMed  CAS  Google Scholar 

  7. W. Andrew and M. A. Bari, Some aspects of age changes in the spinal cord compared with those in other parts of the nervous system, in Proc. of the Fifth International Cong. of Neuropathology, Excerpta Medica Foundation, New York, 1965. International Congress Ser. No. 100, pp. 518–525.

    Google Scholar 

  8. H. M. Wahal and H. H. Riggs, Changes in the brain associated with senility, Arch. Neurol. Psychiat. Chicago 2:151 (1960).

    Article  Google Scholar 

  9. W. Bondereff, Histophysiology of the aging nervous system, in Advances in Gerontological Research (B. L. Strehler, ed.), Vol. 1, Academic Press (1964), p. 1.

    Google Scholar 

  10. E. W. Dempsey, Mitochondrial changes in different physiological states, in Ciba Foundation Colloquia on Aging (G. E. W. Wolstenholme and E. C. P. Millar, eds.), Vol. 2: Aging in Transient Tissues, Little, Brown, Boston (1956), pp. 100–102.

    Google Scholar 

  11. W. Andrew, comments in The Biology of Aging (B. L. Strehler et al., eds.), Publ. No. 6, Am. Inst. Biol. Sci., Washington (1960), p. 37.

    Google Scholar 

  12. S. L. Palay and G. E. Palade, The fine structure of neurons, J. Biophys. Biochem. Cytol. 1:69 (1954).

    Article  Google Scholar 

  13. A. Bethe and M. Fluck, Uber das gelbe Pigment der Ganglienzellen, seine kolloidchemischen and topographischen Beziehungen zu andern Zells-trukturen und eine elekive Methode zu seiner Darstellung, Z. Zellforsch 27:211 (1937).

    Article  Google Scholar 

  14. N. M. Sulkin and P. Srivanij, The experimental production of senile pigments in the nerve cells of young rats, J. Gerontol. 15:2 (1960).

    Article  PubMed  CAS  Google Scholar 

  15. H. P. von Hahn and E. Fritz, Age-related alterations in the structure of DNA. III Thermal stability of rat liver DNA related to age, histone content and ionic strength, Gerontologia, Basel 12:237 (1966).

    Article  Google Scholar 

  16. D. I. Kurtz and F. M. Sinex, Age-related differences in the Association of brain DNA and nuclear protein, Biochim. Biophys. Acta 145:140 (1967).

    Google Scholar 

  17. R. C. Huang and J. Bonner, Histone, a suppressor of chromosomal RNA synthesis, Proc. Nat. Acad. Sci. U.S. 48:1216 (1962).

    Article  CAS  Google Scholar 

  18. R. L. Herrmann, Gene interactions in lower organisms as models for development and aging, J. Gerontol. 22:Part II, 9 (1967).

    Article  PubMed  CAS  Google Scholar 

  19. M. Burger, Der desoxyribonucleursaure- und ribonuclensaure-gehalt des menschlichen Gehirns im Laufe des Levens, J. Altenforsch. 12:133 (1958).

    CAS  Google Scholar 

  20. J. Cammermayer, Cytological manifestations of aging in rabbit and chinchilla brains, J. Geront. 18:41 (1963).

    Article  Google Scholar 

  21. A. Yajima, The nucleic acid content of the brain tissue of rats as influenced by age, Tohuku J. Exp. Med. 85:259 (1965).

    Article  Google Scholar 

  22. H. P. von Hahn, Distribution of DNA and RNA in the brain during the life span of the albino rat, Gerontologia, Basel 12: 18 (1966).

    Article  CAS  Google Scholar 

  23. V.J. Wulff and M. Freshman, Age-related reduction of RNA content of rat cardiac muscle and cerebellum, Arch. Biochem. Biophys. 95:181 (1961).

    Article  PubMed  CAS  Google Scholar 

  24. M. J. Wayner, V. J. Wulff, and M. Piekielniak, Ribonucleic acid content of tissues of rats of various ages, J. Gerontol. 17:455 (1962).

    Google Scholar 

  25. V. J. Wulff, H. Quastler, and F. G. Sherman, The incorporation of 3H-cytidine in mice of different ages, Arch. Biochem. Biophys. 95:548 (1961).

    Article  PubMed  CAS  Google Scholar 

  26. V. J. Wulff, H. Quastler, F. G. Sherman, and H. V. Samis, The effect of specific activity of 3H-cytidine on its incorporation into tissues of young and old mice, J. Gerontol. 20:34 (1965).

    Article  PubMed  CAS  Google Scholar 

  27. A. V. Palladin, Y. V. Belik, and L. I. Kracko, Rate of protein renewal in the brain in states of stimulation and inhibition at different ages of the test animal, Biokhymia 22:359 (1957).

    CAS  Google Scholar 

  28. S. Oeriu, Proteins in development and senescence, in Advances in Gerontological Research (B. L. Strehler, ed.), Vol. 1, Academic Press, New York (1964), pp. 23–78.

    Google Scholar 

  29. B. Jakoubek, E. Gutmann, J. Fischer, and A. Babicky, Rate of protein renewal in spinal motoneurons of adolescent and old rats, J. Neurochem. 15:633 (1968).

    Article  PubMed  CAS  Google Scholar 

  30. A. Lajtha and J. Toth, The brain barrier system. II. Uptake and transport of amino acids by the brain, J. Neurochem. 8:216 (1961).

    Article  PubMed  CAS  Google Scholar 

  31. E. C. Weinbach and J. Garbus, Age and oxidative phosphorylation in rat liver and brain, Nature 178:1225 (1956).

    Article  PubMed  CAS  Google Scholar 

  32. R. Carubelli, Changes in rat brain neuraminidase during development, Nature 219:955 (1968).

    Article  PubMed  CAS  Google Scholar 

  33. S.-C. Sung, Deoxyribonucleases from rat brain, J. Neurochem. 15:477 (1968).

    Article  PubMed  CAS  Google Scholar 

  34. J. M. Reiner, The effect of age on carbohydrate metabolism of tissue homogenates, J. Gerontol. 2:315 (1947).

    Article  PubMed  CAS  Google Scholar 

  35. D. D. Hendley, B. L. Strehler, M. C. Reporter, and M. V. Gee, Further studies on human cardiac age pigment, Fed. Proc. 20:298 (1961).

    Google Scholar 

  36. H. P. Hahn, A model of “regulatory” aging of the cell at the gene level, J. Gerontol. 21:291 (1966).

    Article  Google Scholar 

  37. V. J. Wulff, H. Quastler, and F. G. Sherman, An hypothesis concerning RNA metabolism and aging, Proc. Nat. Acad. Sci. U.S. 48:1373 (1962).

    Article  CAS  Google Scholar 

  38. Zh. A. Medvedev, The nucleic acids in development and aging, in Advances in Gerontological Research (B. L. Strehler, ed.), Vol. 1, pp. 181–206, Academic Press, New York (1964).

    Google Scholar 

  39. R. Pearl, S. L. Parker, and B. M. Gonzalez, Experimental studies on the duration of life, VII. The Mendelian inheritance of duration of life in crosses of wild type and quintuple stocks of Drosophila melanogaster, Am. Naturalist 57:153 (1923).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Herrmann, R.L. (1971). Aging. In: Metabolic Turnover in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7169-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7169-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7171-1

  • Online ISBN: 978-1-4615-7169-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics