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Cerebral Metabolism in Vivo

  • Chapter
Chemical Architecture of the Nervous System

Abstract

In reference to studies on the uptake of amino acids from blood, Waelsch(1) pointed out that “Experiments in which the amino acid concentration in blood is raised to an unphysiological level may elicit an aspect of the blood—brain barrier not operative under physiological conditions. For determining the uptake of amino acids of the brain under physiological conditions, accurate measurements of the arterio—venous differences would be required.” Although brain slices in vitro and other brain preparations have proved of considerable value in biochemical research, it is true that, as Geiger(2) observed, “they obviously do not possess all the metabolic machinery which is involved in the physiological activity of the nerve cell.”

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  1. Research Center, Rockland State Hospital, Orangeburg, New York, USA

    William Sacks

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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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Sacks, W. (1969). Cerebral Metabolism in Vivo . In: Lajtha, A. (eds) Chemical Architecture of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7154-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-7154-4_15

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