Repair, Mutation and Recombination in Bacteria
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When bacterial cells are irradiated with ultraviolet radiation at 254 nm, dimers are formed between adjacent pyrimidines in the same strand of a DNA duplex. The biochemical and genetic study of how the cell deals with this damage has provided a fascinating insight into the genes and proteins involved in replicating, repairing and recombining DNA molecules. It has also provided some indication as to how ultraviolet-induced mutation can occur.
KeywordsExcision Repair Single Strand recA Protein Bacterial Chromosome Phage Recombination
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- Hanawalt, P. C. (1975) Repair models and mechanisms: overview, in Molecular Mechanism for Repair of DNA, part B (eds. P. C. Hanawalt and R. B. Setlow), Plenum Press, New York, 431–437.Google Scholar
- Whitehouse, H. L. K. (1982) Genetic Recombination, Understanding the Mechanisms, John Wiley and Sons, Chichester.Google Scholar
- Witkin, E. M. (1969) The role of DNA repair and recombination in mutagenesis, in Proc. XII Int. Congr. on Genetics 3, 225–245.Google Scholar
- Witkin, E. M. (1976) Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bact. Rev. 40, 869–907.Google Scholar
- The following symposium reported many findings relevant to replication and recombination: Cold Spring Harbor Symposia on Quantitative Biology (1979) 43, Parts 1 and 2. DNA: Replication and Recombination, Cold Spring Harbor Laboratory.Google Scholar