Advertisement

Aspects of Fungal Genetics

Chapter
  • 92 Downloads
Part of the Tertiary Level Biology book series (TLB)

Abstract

The study of fungal genetics has made a number of significant contributions to our knowledge of genetic processes. The early idea of the connection between genes and enzymes was based on nutritional mutants of Neurospora, and rapid progress in bacterial genetics occurred when this approach and selective techniques were extended to Escherichia coli. One major advantage which some fungi have over bacteria is the occurrence of meiosis in a closed sac, the ascus in the ascomycetes. This allows the genetic effects of a single meiotic event to be studied in detail. There is nothing comparable in bacteria and very often selective techniques are necessary even to detect bacterial recombination. In addition, fusion of nuclei followed by meiosis does not occur in the bacteria. The result of this has been that fungal genetics has made a significant contribution to basic ideas on mechanisms of recombination. In general bacteria are easier to handle for biochemical analysis, and therefore the biochemical basis of recombination is better understood in bacteria than in fungi. This chapter will examine some of the important experiments on recombination in fungi and will include details of the parasexual cycle which occurs in a variety of filamentous fungi.

Keywords

Linkage Group Fruiting Body Gene Conversion Aspergillus Nidulans Fungal Genetics 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bainbridge, B. W. (1970) Genetic analysis of an unequal chromosomal translocation in Aspergillus nidulans. Genet. Res. 15, 317–326.CrossRefGoogle Scholar
  2. Bainbridge, B. W. (1984) Genetic analysis of Aspergillus nidulans, life cycle and genetic processes in a filamentous fungus. Micro. Sci. 1(8), 197–198.Google Scholar
  3. Bainbridge, B. W. and Roper, J. A. (1966) Observations on the effects of a chromosome duplication in Aspergillus nidulans. J. Gen. Microbiol. 42, 417–424.CrossRefGoogle Scholar
  4. Ball, C. (1973) The genetics of Penicillium chrysogenum, in Progress in Industrial Microbiology 12, 47–72.Google Scholar
  5. Ball, C. (1984) Filamentous fungi, in Genetics and Breeding of Industrial Microorganisms (ed. C. Ball), CRC Press, Boca Raton.Google Scholar
  6. Berg, C. M. and Garber, E. D. (1962) A genetic analysis of color mutants in Aspergillus fumigatus. Genetics 47, 1139–1146.Google Scholar
  7. Buxton, E. W. (1956) Heterokaryons and parasexual recombination in pathogenic strains of Fusarium oxysporum. J. gen. Microbiol. 15, 133–139.CrossRefGoogle Scholar
  8. Caten, C.E. (1981) Parasexual processes in fungi, in The Fungal Nucleus (eds. K. Gull and S. G. Oliver), Cambridge University Press, Cambridge.Google Scholar
  9. Casselton, L. A. (1965) The production and behaviour of diploids of Coprinus lagopus. Genet. Res. 6, 190–208.CrossRefGoogle Scholar
  10. Foley, J. M., Giles, N. H. and Roberts, C. F. (1965) Complementation at the adenylosuccinate locus in Aspergillus nidulans. Genetics 52, 1247–1263.Google Scholar
  11. Hastie, A. C. (1964) The parasexual cycle in Verticillium albo-atrum. Genet. Res. 5, 305–315.CrossRefGoogle Scholar
  12. Hastie, A. C. (1967) Mitotic recombination in conidiophores of Verticillium albo-atrum. Nature, London 214, 249–252.CrossRefGoogle Scholar
  13. Hastie, A. C. (1970) Benlate-induced instability of Aspergillus diploids. Nature, London 226, 771.CrossRefGoogle Scholar
  14. Heagy, F. C. and Roper, J. A. (1952) Deoxyribonucleic acid content of haploid and diploid Aspergillus conidia, Nature, London 170, 713–714.CrossRefGoogle Scholar
  15. Holliday, R. (1961) Induced mitotic crossing over in Ustilago maydis. Genet. Res. 2, 231–248.CrossRefGoogle Scholar
  16. Holliday, R. (1974) Molecular aspects of genetic exchange and gene conversion. Genetics 78, 273–287.Google Scholar
  17. Käfer, E., Marshall, P. and Cohen, G. (1976) Well-marked strains of Aspergillus for tests of environmental mutagens: identification of induced mitotic recombination and mutation. Mut. Res. 38, 141–146.CrossRefGoogle Scholar
  18. Käfer, E. (1977) Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Adv. Genet. 19, 33–131.CrossRefGoogle Scholar
  19. Kitani, Y., Olive, L. S. and El-Ani, A. S. (1962) Genetics of Sordaria fimicola. V. Aberrant segregation at the g locus. Amer. J. Bot. 49, 697–706.CrossRefGoogle Scholar
  20. Lhoas, P. (1961) Mitotic haploidization by treatment of Aspergillus niger diploids with p-fluorophenylalanine. Nature, London 190, 744.CrossRefGoogle Scholar
  21. Lindegren, C. C. (1953) Gene conversion in Saccharomyces. J. Genet. 51, 625–637.CrossRefGoogle Scholar
  22. Lissouba, P., Mousseau, J., Rizet, G. and Rossignol, J. L. (1962) Fine structure of genes in the ascomycete Ascobolus immersus. Adv. Genet. 11, 343–380.CrossRefGoogle Scholar
  23. Meselson, M. and Radding, C. M. (1975) A general model for genetic recombination. Proc. Nat. Acad. Sci. Wash. 72, 358–361.CrossRefGoogle Scholar
  24. Nüesch, J., Treichler, H. J. and Liersch, M. (1973) The biosynthesis of cephalosporin C., in Genetics of Industrial Microorganisms, Actinomycetes and Fungi (eds. Z. Vanek, Z. Hostalek and J. Cudlin), Academia, Prague, 309–334.Google Scholar
  25. Olive, L. S. (1959) Aberrant tetrads in Sordaria fimicola. Proc. Nat. Acad. Sci. Wash. 45, 727–732.CrossRefGoogle Scholar
  26. Pontecorvo, G. (1952) Non-random distribution of multiple mitotic crossing-over among nuclei of heterozygous diploid Aspergillus. Nature, London 170, 204.CrossRefGoogle Scholar
  27. Pontecorvo, G. and Käfer, E. (1958) Genetic analysis by means of mitotic crossing over. Adv. Genet. 9, 71–104.CrossRefGoogle Scholar
  28. Pontecorvo, G., Roper, J. A., Hemmons, L. M., MacDonald, K. D. and Bufton, A. W. J. (1953) The genetics of Aspergillus nidulans. Adv. Genet. 5, 141–238.CrossRefGoogle Scholar
  29. Pontecorvo, G. and Sermonti, G. (1953) Recombination without sexual reproduction in Penicillium chrysogenum. Nature, London 172, 126.CrossRefGoogle Scholar
  30. Roman, H. (1956) Studies on gene mutation in Saccharomyces. Cold Spring Harb. Symp. Quant. Biol. 21, 175–183.CrossRefGoogle Scholar
  31. Roper, J. A. (1952) Production of heterozygous diploids in Aspergillus nidulans. Experientia 8, 14–15.CrossRefGoogle Scholar
  32. Roper, J. A. (1966) The parasexual cycle, in The Fungi, vol. 2, Academic Press, New York, 589–617.Google Scholar
  33. Roper, J. A. and Käfer, E. (1957) Acriflavine-resistant mutants of Aspergillus nidulans. J. gen. Microbiol. 16, 660–667.CrossRefGoogle Scholar
  34. Roper, J. A. and Nga, B. H. (1969) Mitotic nonconformity in Aspergillus nidulans: the production of hypodiploid and hyperhaploid nuclei. Genet. Res. 14, 127–163.CrossRefGoogle Scholar
  35. Scazzocchio, C. and Arst, H. N. (1978) The nature of an initiator constitutive mutation in Aspergillus nidulans. Nature, London 274, 177–179.CrossRefGoogle Scholar
  36. Scazzocchio, C. and Girton, D. (1977) The regulation of purine breakdown, in The Genetics and Physiology of Aspergillus (eds. J. E. Smith and J. A. Pateman), Academic Press, London.Google Scholar
  37. Singh, M. and Sinha, U. (1976) Chloral hydrate induced haploidization in Aspergillus nidulans. Experientia 32, 1144–1145.CrossRefGoogle Scholar
  38. Whitehouse, H. L. K. (1982) Genetic Recombination, Understanding the Mechanisms. J. Wiley and Sons, Chichester.Google Scholar
  39. Wood, S. and Käfer, E. (1967) Twin spots as evidence for mitotic crossing over in Aspergillus induced by ultraviolet light. Nature, London 216, 63–64.CrossRefGoogle Scholar

Copyright information

© Blackie & Son Ltd 1987

Authors and Affiliations

  1. 1.King’s College LondonUK

Personalised recommendations