Construction of Genetic Maps and the Genetic Code
- 91 Downloads
One of the major achievements of genetics has been to work out arrangements of genes relative to each other. Initial work showed free segregation of genes, as already described, which is expected when two loci are on non-homologous chromosomes. However, when the two loci are close together on homologous chromosomes they tend to segregate together at meiosis, i.e. they are said to be linked. The frequency with which re-assortment or recombination occurs is a measure of the distance between the two loci, and this can be used to construct a genetic map.
KeywordsCoat Protein Genetic Code Initiation Codon Aspergillus Nidulans Lytic Enzyme
Unable to display preview. Download preview PDF.
- Cove, D. (1977) The genetics of Aspergillus, in Genetics and Physiology of Aspergillus (ed. Smith, J. E. and Pateman, J. A.), Academic Press, London, 81–95.Google Scholar
- Davidson, N. and Szybalski, W. (1971) Physical and chemical characteristics of lambda DNA, in The Bacteriophage Lambda (ed. Hershey, A. D.), Cold Spring Harbor Laboratory, 45–82.Google Scholar
- Davis, R. W., Simon, M. and Davidson, N. (1971) Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids, in Methods in Enzymology 21, 413–428.Google Scholar
- Murray, K. (1978) Restriction enzymes and their uses in genetic engineering, in Genetic Engineering (ed. A. M. Chakrabarty), CRC Press, Florida.Google Scholar
- Murray, K. and Murray, N. E. (1975) Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli. J. mol. Biol. 98, 551–564.Google Scholar
- Old, R. W. and Primrose, S. B. (1985) Principles of Gene Manipulation, 3rd edn., Blackwell Scientific, Oxford.Google Scholar
- Platt, T. (1985) Control of gene expression in bacteria, in Genetics of Bacteria (eds. J. Scaife, D. Leach and A. Galizzi), Academic Press, London, 255–278.Google Scholar
- Smith-Keary, P. F. (1975) Genetic Structure and Function, Macmillan, London.Google Scholar
- Whitehouse, H. L. K. (1982) Genetic Recombination, Understanding the Mechanisms, John Wiley and Sons, Chichester.Google Scholar