Factors Modifying the Effect of Prostaglandin E1 on Lipolysis in Adipose Tissue

  • Horace Micheli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


The antilipolytic property of prostaglandins E (PGE) is well known (1). The mechanism behind this effect and its physiological role are not yet clear. Prostaglandins have been extracted from adipose tissue as well as from other tissues (2,3). Catecholamines and nerve stimulation have been shown to provoke secretion of prostaglandins, e.g., from rat epididymal fat pad in vitro (4). Most of the observations about the activity of prostaglandins in adipose tissue in vitro have been made on rats (1,2) and only a few in human tissue (5), with similar results. Systematic studies on the effect of PGE1, on lipolysis with regard to factors such as species, age, nutritional state and hormonal balance are lacking. A condition known to abolish the antilipolytic effect of PGE1 in rat is the fasting state (6,7). The purpose of this study was to explore species differences of PGE1 effects with reference to factors modifying lipolysis.


Adipose Tissue Nicotinic Acid Glycerol Release PERIRENAL Adipose Tissue Antilipolytic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Steinberg, D., Vaughan, M., Nestel, P. and Bergström, S. Biochem. Pharmacol. 12: 764 (1963)PubMedCrossRefGoogle Scholar
  2. 2.
    Bergström, S., Carlson, L.A. and Weeks, J.R. Pharmacol. Rev. 20: 1 (1968)PubMedGoogle Scholar
  3. 3.
    Karim, S.M.M., Sandler, M. and Williams, E.D. Brit J. Pharmacol. Chemother. 31: 340 (1967)Google Scholar
  4. 4.
    Shaw, J. and Ramwell, P.W. J. Biol. Chem. in pressGoogle Scholar
  5. 5.
    Bergström, S. and Carlson, L.A, Acta Physiol. Scand. 63: 195 (1965)CrossRefGoogle Scholar
  6. 6.
    Carlson, L.A. Progr. Biochem. Pharmacol. 3: 94 (1967)Google Scholar
  7. 7.
    Stock, K. and Westermann, E. Arch. Pharm. Exp. Path. 254: 334 (1966)Google Scholar
  8. 8.
    Bizzi, A. and Carlson, L.A. Life Sci. 4: 2123 (1965)PubMedCrossRefGoogle Scholar
  9. 9.
    Wieland, O. Biochem. Z. 329: 313 (1957)PubMedGoogle Scholar
  10. 10.
    Butcher, R.W. and Baird, C.E. J. Biol. Chem. 243: 1713 (1968)Google Scholar
  11. 11.
    Steinberg, D. and Vaughan, M. in Prostaglandins, Proc. II Nobel Symp. (S. Bergström and B. Samuelsson, Eds.) p. 109. Almqvist & Wiksell, Stockholm (1967)Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Horace Micheli
    • 1
  1. 1.King Gustaf Vth Research InstituteKarolinska HospitalStockholmSweden

Personalised recommendations