Adenosine 3′,5′-Monophosphate and Regulation of Lipolysis in Rat Adipose Tissue

  • B. Mosinger
  • M. Vaughan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


The results of experiments from several laboratories have provided evidence that adenosine 3′,5′-monophosphate (cyclic AMP) might play a key role in the hormonal regulation of lipid mobilization. Available supporting data include the existence of adenyl cyclase in adipose tissue (1), the simultaneous stimulation of Phosphorylase and lipolysis by several hormones (2), rapid increase of the concentration of cyclic AMP in adipose tissue incubated with epinephrine and methyl xanthines (3), and reactivation of lipase activity in cell-free preparations by cyclic AMP and ATP (4).


Adipose Tissue Free Fatty Acid Adenyl Cyclase Incubation Medium Lipid Mobilization 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • B. Mosinger
    • 1
    • 2
  • M. Vaughan
    • 1
    • 2
  1. 1.Laboratory of Metabolic RegulationsInstitute of Human NutritionPragueCzechoslovakia
  2. 2.Laboratory of Metabolism, National Heart InstituteNIHBethesdaUSA

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