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Evidence That the Rise in Temperature Produced by d-Amphetamine is Caused by a Peripheral Action of the Drug

  • G. L. Gessa
  • G. A. Clay
  • B. B. Brodie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)

Abstract

It is not always easy to decide the extent to which certain “central” effects of drugs might be mediated peripherally or might result from interfering with a peripheral signal to the brain. We became concerned with this problem after the demonstration that the pronounced hyperactivity elicited by large doses of triiodothyronine in mice was markedly reduced by ganglionic blocking agents, such as chlorisondamine. Since amphetamine acts indirectly through the release of NE (1), we are investigating the possibility that those effect to which tolerance is readily acquired might result from a depletion of catecholamine stores at the locus of action.

Keywords

Adipose Tissue Nicotinic Acid Specific Dynamic Action Peripheral Signal Hyperthermic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Weissman, A., Koe, B. K. and Tenen, S. S,: J. Pharmac. exp. Ther. 151: 339 (1966).Google Scholar
  2. 2.
    Beyer, K. H.: J. Pharmac. exp. Ther. 66: 318–325 (1939).Google Scholar
  3. 3.
    von Euler, C: Pharmac. Rev. 13: 361 (1961).Google Scholar
  4. 4.
    Belenky, M. L. and Vitolina, M.: Int. J. Neuropharmac. 1: 1 (1962).CrossRefGoogle Scholar
  5. 5.
    Obal, F., Kelemen, A. and Feszt, G.: Acta Physiol. VII: 199 (1955).Google Scholar
  6. 6.
    Harrison, J. W. E., Ambrus, C. M. and Ambrus, J. L.: J. Am. pharm. Ass. 41: 539 (1952).CrossRefGoogle Scholar
  7. 7.
    Brodie, B. B., Comer, M. S., Costa, E. and Dlabac, A.: J. Pharmac. exp. Ther. 152: 340 (1966).Google Scholar
  8. 8.
    Novak, M.: J. Lipid Res. 6: 431 (1965).PubMedGoogle Scholar
  9. 9.
    Maickel, R. P., Cox, R. H., Segal, D. S. and Miller, F. P.: Fedn Proc. Fedn Am. Socs exp. Biol. 25: 385 (1966).Google Scholar
  10. 10.
    Crabai, F., Piras, L., Spano, P. F., Vargiu, L., Tagliamonte, A. and Gessa, G. L.: Boll. Soc. ital. Biol. sper. XLIII: 1267 (1967).Google Scholar
  11. 11.
    Stock, K. and Westermann, E.: Arch. exp. Path. Pharmak. 254: 334 (1966).Google Scholar
  12. 12.
    Strominger, J. L. and Brobeck, J. R.: Yale J. Biol. Med. 25: 383 (1953).PubMedGoogle Scholar
  13. 13.
    Mantegazza, P., Naimzada, K. M. and Riva, M.: Europ. J. Pharmac. 4: 25 (1968).CrossRefGoogle Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • G. L. Gessa
    • 1
  • G. A. Clay
    • 1
  • B. B. Brodie
    • 1
  1. 1.Laboratory of Chemical PharmacologyNational Heart InstituteBethesdaUSA

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