Effect of Hypocholesteremic Agents on an Experimental Brain Tumor in Mice

  • E. Grossi Paoletti
  • C. R. Sirtori
  • J. F. Weiss
  • R. Paoletti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


Dietary deficiencies in lipids and cholesterol are known to have a retarding effect on the growth of some experimental tumors (1). A growth retardation was also observed for various experimental tumors after the administration of drugs interfering with cholesterol synthesis (2). These effects might be due to a reduced availability of cholesterol for the growth of experimental tumors, as partially confirmed by the increased incidence of spontaneous mammary carcinomas and brain tumors in mice fed diets very rich in cholesterol (3,4).


Brain Tumor Cholesterol Biosynthesis Total Sterol Sterol Composition Sterol Level 
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  1. 1.
    Littman, M. L., Taguchi, T., and Shimizu, Y. Proc. Soc. Exptl. Biol. Med. 116:95 (1964)Google Scholar
  2. 2.
    Littman, M. L., Taguchi, T., and Mosbach, E.H. Cancer Chem. Rep. 50:25 (1966)Google Scholar
  3. 3.
    Szepsenwol, J. Proc. Soc. Exptl. Biol. Med. 121:168 (1966)Google Scholar
  4. 4.
    Szepsenwol, J. Proc. Am. Assoc. Cancer Res. 9:Abs. 275 (1968)Google Scholar
  5. 5.
    Henderson, J. F. and Lepage, G. A. Cancer Res. 19:887 (1959)Google Scholar
  6. 6.
    Gore, I. Y. Nature 202:800 (1964)CrossRefGoogle Scholar
  7. 7.
    Spector, A.A. and Steinberg, D. Cancer Res. 27:1587 (1967)PubMedGoogle Scholar
  8. 8.
    Stein, A.A., Qpalka, E., and Rosenblum, I. Cancer Res. 25:957 (1965)PubMedGoogle Scholar
  9. 9.
    Siperstein, M. D. and Fagan, V.M. Cancer Res. 24:1103 (1964)Google Scholar
  10. 10.
    Azarnoff, D. L., Curran, G. L., and Williamson, W. P. J. Nat. Cancer Inst. 21:1109 (1958)Google Scholar
  11. 11.
    Fumagalli, R., Grossi Paoletti, E., Paoletti, P., and Paoletti, R. J. Neurochem. 11:56l (1964)CrossRefGoogle Scholar
  12. 12.
    Fumagalli, R., Grossi Paoletti, E., Paoletti, P., and Paoletti, R. J. Neurochem. 13:1005 (1966)PubMedCrossRefGoogle Scholar
  13. 13.
    Paoletti, R., Grossi Paoletti, E., and Fumagalli, R. “Handbook of Neurochemistry,” Ed. L. Lajtha, Plenum Press, N. Y. (1968 in press)Google Scholar
  14. 14.
    Larionov, L. F., Degteva, S.A., and Lesnaia, N.A. Vop. Onkol. 8:12 (1962)Google Scholar
  15. 15.
    Degteva, S.A. Acta Unio Int. Cancer 20:153 (1964)Google Scholar
  16. 16.
    Owens, G., Javid, R., and Belmusto, L. Proc. Am. Assoc. Cancer Res. 5:49 (1964)Google Scholar
  17. 17.
    Owens, G., Javid, R., Belmusto, L., Bender, M., and Blau, M. Cancer, N. Y. 18:756 (1965)PubMedGoogle Scholar
  18. 18.
    “Protocols for Screening Chemical Agents and Natural Products against Animal Tumors and other Biological Systems.” Cancer Chemother. Rep. No. 25 (December 1962)Google Scholar
  19. 19.
    Lowry, O. H., Rosebrough, N.J., Lewis Farr, A., and Randall, R.J. J. Biol. Chem. 193:265 (1951)Google Scholar
  20. 20.
    Galli, G. and Grossi Paoletti, E. Lipids 2:72 (1967)CrossRefGoogle Scholar
  21. 21.
    Avoy, D.R., Swyryd, E. A., and Gould, R. G. J. Lipid Res. 6:369 (1965)PubMedGoogle Scholar
  22. 22.
    Gould, R. G., Swyryd, E. A., Avoy, D., and Coan, B. in Prog. Biochem. Pharmacol. 2, Ed. D. Kritchevsky, R. Paoletti and D. Steinberg. S. Karger, Basel (1967) p. 345Google Scholar
  23. 23.
    Holmes, W. L. in “Lipid Pharmacology,” Ed. R. Paoletti. Acad. Press, N. Y. (1964) p. 131Google Scholar
  24. 24.
    Krami, M., Bagli, J. F., and Dvornik, D. Biochem. Biophys. Res. Comm. 15:455 (1964)CrossRefGoogle Scholar
  25. 25.
    Steinberg, D. and Avigan, J. J. Biol. Chem. 232:3127 (1960)Google Scholar
  26. 26.
    Thompson, M.J., Dupont, J., and Robbins, W. E. Steroids 2:99 (1963)CrossRefGoogle Scholar
  27. 27.
    Horlick, L. J. Lipid Res. 7:116 (1965)Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • E. Grossi Paoletti
    • 1
  • C. R. Sirtori
    • 1
  • J. F. Weiss
    • 1
  • R. Paoletti
    • 1
  1. 1.Institute of PharmacologyUniversity of MilanMilanItaly

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