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The Efficacy of Clofibrate (CPIB) in Familial Hyperlipoproteinemias

  • Robert I. Levy
  • Steven H. Quarfordt
  • W. Virgil Brown
  • Howard R. Sloan
  • Donald S. Fredrickson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)

Abstract

This presentation will describe the use of diet, Clofibrate, and one other drug on the treatment of different kinds of familial hyperlipidemia. The latter disorders were classified as different types of hyperlipoproteinemia (1). The use of such grouping of patients has many distinct advantages. Probably these are greatest in pharmacologic or dietary experiments and the extension of the results to practical management of affected patients. This has been demonstrated in the systematic trial of Clofibrate (CPIB, Atromid-S®) on each of the five major types of familial hyperlipoproteinemia. The companion effects of drug and diet have also been carefully evaluated. A fuller description of each type of hyperlipoproteinemia is presented elsewhere in this symposium (2).

Keywords

Plasma Cholesterol Plasma Triglyceride Creatine Phosphokinase Diet Therapy Peripheral Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Robert I. Levy
    • 1
  • Steven H. Quarfordt
    • 1
  • W. Virgil Brown
    • 1
  • Howard R. Sloan
    • 1
  • Donald S. Fredrickson
    • 1
  1. 1.Molecular Disease Branch, National Heart InstituteNational Institutes of HealthBethesdaUSA

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