Selective Inhibition of Hepatic but Not Intestinal β-Lipoprotein Production and Triglyceride Transport in Rats Given Orotic Acid

  • H. G. Windmueller
  • R. I. Levy
  • Albert E. Spaeth
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


Orotic acid (l,2,3,6-tetrahydro-2,6 dioxo-4-pyrimidinecarboxylic acid; uracil-4-carboxylic acid), synthesized by mammalian cells from aspartic acid and carbamyl phosphate, is an intermediate in the pathway leading to the biosynthesis of pyrimidine nucleotides (1). Animals have no nutritional requirement for orotic acid. Its intracellular concentration is very low, since In the presence of ribosylpyrophosphate 5-phosphate (PP-ribose-P) it is efficiently converted to the nucleotide, orotidylic acid (2), which in turn is decarboxylated to uridylic acid, or UMP. UMP is a precursor for all other cellular pyrimidine nucleotides.


Fatty Liver Orotic Acid Plasma Lipid Concentration Carbamyl Phosphate Intestinal Lymph 
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Copyright information

© Pleum Press 1969

Authors and Affiliations

  • H. G. Windmueller
    • 1
  • R. I. Levy
    • 2
  • Albert E. Spaeth
    • 1
  1. 1.National Institute of Arthritis and Metabolic DiseasesBethesdaUSA
  2. 2.National Heart InstituteBethesdaUSA

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