The Effect of Nicotinic Acid Treatment on the Chemical Composition of Plasma Lipoprotein Classes in Man

  • Lars A. Carlson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


Nicotinic acid is one of several available agents which lower the levels of plasma lipids (1). For several years, we have been using nicotinic acid in the treatment of patients with coronary heart disease and elevated plasma lipid levels. In our clinical experience we have been impressed by its effectiveness in lowering both plasma triglycerides and plasma cholesterol. This suggested to us that nicotinic acid reduced the levels of both the triglyceride- rich very-low-density (VLD) lipoproteins (LP) and the cholesterol-rich low-density (LD) LP. The purpose of this study was to establish
  1. 1)

    Does treatment with nicotinic acid lower the levels of both VLD- and LD-LP in various types of hyperlipoproteinemia?

  2. 2)

    Does treatment with nicotinic acid change the chemical composition of the three major plasma LP classes?



Cholesterol Content Plasma Triglyceride Plasma Lipoprotein Triglyceride Content Lipoprotein Composition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Altschul, R. Niacin in vascular disorders and hyperlipemia (Ed. by R. Altschul), Charles C. Thomas, Springfield, Ill. (1964)Google Scholar
  2. 2.
    Carlson, L. A. and Orö, L. Läkartidn. 63: 4281 (1966)Google Scholar
  3. 3.
    Carlson, L. A. and Orö, L. to be publishedGoogle Scholar
  4. 4.
    Carlson, L. A. and Mossfeldt, F. Acta Physiol. Scand. 62: 51 (1964)PubMedCrossRefGoogle Scholar
  5. 5.
    Smith, E. B. Lancet ii: 530 (1962)CrossRefGoogle Scholar

Copyright information

© Pleum Press 1969

Authors and Affiliations

  • Lars A. Carlson
    • 1
  1. 1.Department of Internal MedicineKarolinska sjukhuset and King Gustaf V. Research InstituteStockholmSweden

Personalised recommendations