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Carnitine Regulation of Fatty Acid Metabolism in Heart

  • G. V. Vahouny
  • S. L. Rodis
  • E. Koch
  • P. D’Amato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)

Abstract

Recent investigations of the distribution and functions of carnitine (β-hydroxy-γ-trimethyl ammonium butyrate) and its derivatives, have led to the general concept that carnitine may be involved in acyl group transfer from extra- to intramitochondrial compartments (l). According to this view, fatty acids are activated to CoA derivatives and transferred to mitochondria. At the outer mitochondrial membrane, carnitine acyl transferase (acyl CoA:carnitine O-acyl transferase) catalyzes transfer of the acyl group from CoA to carnitine, thereby facilitating membrane transport of the long-chain fatty acid. The acyl group is subsequently reconverted to the CoA derivative at the intramitochondrial site of fatty acid oxidation. Consonant with this hypothesis are the following evidences: a) carnitine favors the formation of acyl-carnltine, which in turn is a requisite for increased oxidation of the acyl group by isolated mitochondria (2); b) the rate of transfer of acyl groups across the mitochondrial membrane is presumably the main determinant of the rate of fatty acid oxidation (3); c) palmityl carnitine competitively inhibits carnitine stimulation of fatty acid oxidation in heart mitochondria (4).

Keywords

Fatty Acid Oxidation Fatty Acid Synthesis Heart Mitochondrion Perfuse Heart Acetyl Carnitine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • G. V. Vahouny
    • 1
  • S. L. Rodis
    • 1
  • E. Koch
    • 1
  • P. D’Amato
    • 1
  1. 1.Biochemistry Dept., School of MedicineThe George Washington UniversityUSA

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