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Effects of Estradiol-17β and Progesterone on Experimental Mammary Carcinoma Lipid

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Drugs Affecting Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

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Abstract

Like the parent mammary epithelium, many of the mammary carcinomas induced by the polycyclic hydrocarbons, 3-methylcholanthrene (3-MC) and 7,12-dimethylbenz(a)anthracene (DMBA), respond to hormonal changes in the host. Two kinds of responsiveness have been demonstrated: a) regression after ovariectomy, and b) lipid accumulation following high doses of estradiol-17β with or without progesterone. Shay et al (1,2) showed the frequent occurrence of mammary carcinomas in the Wistar rat following intragastric administration of 3-MC dissolved In olive oil, and they also demonstrated that the carcinomas regress after ablation of the ovaries. Huggins and his associates (3,4) later discovered the marked sensitivity of the breast tissue of the young, female Sprague-Dawley rat to 3-MC and DMBA. Dose schedules have been worked out by Huggins so that mammary carcinomas now can be induced with virtual certainty in 1007. of these animals. Most of the animals bear several tumors and though some tumors may become very large (100 gms or more), the hosts generally survive for several months. Most of the carcinomas are strikingly hormone dependent in that they regress rapidly after ovariectomy or hypophysectomy.

Supported by grants P-291 and P-388 from the American Cancer Society and NIH grant FR-00158.

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References

  1. Shay, H., Aegerter, E.A., Gruenstein, M., and Komarov, S.A. J.Nat.Cancer Instit. 10: 255 (1949).

    CAS  Google Scholar 

  2. Shay, H., Harris, C., and Gruenstein, M. J.Mat.Cancer Instit. 13: 307 (1952).

    CAS  Google Scholar 

  3. Huggins, C., Briziarelli, G., and Sutton, Jr. H. J.Exp.Med. 109: 25 (1959).

    Article  PubMed  CAS  Google Scholar 

  4. Huggins, C., Grand, L.C., and Brillantes, F.P. Nature 189: 204 (1961).

    Article  PubMed  CAS  Google Scholar 

  5. Rees, E.D. and Huggins, C. Cancer Research 20: 963 (1960).

    PubMed  CAS  Google Scholar 

  6. Rees, E.D., Shuck, A.E. and Ackermann, H. J.Lipid.Res. 7: 396 (1966).

    PubMed  CAS  Google Scholar 

  7. Shelden, H. and Angel, A. Lipid Transport. H. Meng (Ed.) C.C. Thomas, Springfield, I11., 1964.

    Google Scholar 

  8. Smith, S., Watts, R. and Dils, R. J.Lipid Res. 9: 52 (1968).

    PubMed  CAS  Google Scholar 

  9. Rees, E.D., Shuck, A.E. and Ackermann, H. Froc.Soc.Exp.Biol. Med. (in press).

    Google Scholar 

  10. Sterental, A., Dominguez, J.M., Weissman, C., and Pearson, O.H. Cancer Res. 23: 481 (1963).

    PubMed  CAS  Google Scholar 

  11. Jabara, A.G. Brit.J.Cancer 21: 418(1967).

    Article  PubMed  CAS  Google Scholar 

  12. Huggins, C., and Yang, B.C. Science 137: 257 (1962).

    Google Scholar 

  13. Teller, H., Stock, C.C., and Bowie, M. Cancer Res. 26: 2329 (1966).

    PubMed  CAS  Google Scholar 

  14. Ercoli, A. and Briziarelli, G. J.Nat.Cancer Instit. 27: 1173 (1961).

    CAS  Google Scholar 

  15. Heise, E. and Görlich, M. Brit.J.Cancer 20: 539 (1966).

    Article  PubMed  CAS  Google Scholar 

  16. Teller, M.N., Kaufman, R.J., Stock, C.C. and Bowie, M. Cancer Res. 28: 368 (1968).

    PubMed  CAS  Google Scholar 

  17. Kim, U. and Fürth, J. Proc.Soc.Exp.Biol.Med. 103: 643 (1960).

    PubMed  CAS  Google Scholar 

  18. Young, S. and Cowan, D.M. Brit.J.Cancer 27: 85 (1963).

    Article  Google Scholar 

  19. Shimkin, M., Gropper, R., Thatcher, D. and Gruenstein, M. Cancer Res. 27: 11 (1967).

    Google Scholar 

  20. McCoraick, G.M. and Moon, R.C. Cancer Res. 27: 626 (1967).

    Google Scholar 

  21. Dao, T.L., Bock F.G., and Greiner, M.J. J.Nat.Cancer Instit. 25: 991 (1960).

    CAS  Google Scholar 

  22. Shay, H., Gruenstein, M. and Shimkin, M.B. Cancer Res. 24: 998 (1964).

    PubMed  CAS  Google Scholar 

  23. Mobbs, B.G. J.Endocrin. 36: 409 (1966).

    Article  CAS  Google Scholar 

  24. Gorski, J. and Axman, M.C. Arch.Biochem.Biophys. 105: 517 (1964).

    Article  PubMed  CAS  Google Scholar 

  25. Robinson, D.S. and Harris, P.M. Biochem.J. 80: 361 (1961).

    PubMed  CAS  Google Scholar 

  26. Teller, M.N., Stock, C.C, Stohr, G., Merker, P.C., Kaufman, R.J., Escher, G.C. and Bowie, M. Cancer Res. 26: 245 (1966).

    PubMed  CAS  Google Scholar 

  27. Doering, C.H. and Natori, Y. Proc.Soc.Exp.Biol.Med. 118: 957 (1965).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Medicine and Pharmacology and the Clinical Research Center, University of Kentucky, Lexington, Ky., USA

    E. Douglas Rees M.D.

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  1. E. Douglas Rees M.D.
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Plenum Press

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Rees, E.D. (1969). Effects of Estradiol-17β and Progesterone on Experimental Mammary Carcinoma Lipid. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_21

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

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