Effects of Estradiol-17β and Progesterone on Experimental Mammary Carcinoma Lipid

  • E. Douglas Rees
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


Like the parent mammary epithelium, many of the mammary carcinomas induced by the polycyclic hydrocarbons, 3-methylcholanthrene (3-MC) and 7,12-dimethylbenz(a)anthracene (DMBA), respond to hormonal changes in the host. Two kinds of responsiveness have been demonstrated: a) regression after ovariectomy, and b) lipid accumulation following high doses of estradiol-17β with or without progesterone. Shay et al (1,2) showed the frequent occurrence of mammary carcinomas in the Wistar rat following intragastric administration of 3-MC dissolved In olive oil, and they also demonstrated that the carcinomas regress after ablation of the ovaries. Huggins and his associates (3,4) later discovered the marked sensitivity of the breast tissue of the young, female Sprague-Dawley rat to 3-MC and DMBA. Dose schedules have been worked out by Huggins so that mammary carcinomas now can be induced with virtual certainty in 1007. of these animals. Most of the animals bear several tumors and though some tumors may become very large (100 gms or more), the hosts generally survive for several months. Most of the carcinomas are strikingly hormone dependent in that they regress rapidly after ovariectomy or hypophysectomy.


Mammary Gland Lipid Accumulation Mammary Carcinoma Uterine Weight Fatty Acid Synthetase 
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  1. 1.
    Shay, H., Aegerter, E.A., Gruenstein, M., and Komarov, S.A. J.Nat.Cancer Instit. 10: 255 (1949).Google Scholar
  2. 2.
    Shay, H., Harris, C., and Gruenstein, M. J.Mat.Cancer Instit. 13: 307 (1952).Google Scholar
  3. 3.
    Huggins, C., Briziarelli, G., and Sutton, Jr. H. J.Exp.Med. 109: 25 (1959).PubMedCrossRefGoogle Scholar
  4. 4.
    Huggins, C., Grand, L.C., and Brillantes, F.P. Nature 189: 204 (1961).PubMedCrossRefGoogle Scholar
  5. 5.
    Rees, E.D. and Huggins, C. Cancer Research 20: 963 (1960).PubMedGoogle Scholar
  6. 6.
    Rees, E.D., Shuck, A.E. and Ackermann, H. J.Lipid.Res. 7: 396 (1966).PubMedGoogle Scholar
  7. 7.
    Shelden, H. and Angel, A. Lipid Transport. H. Meng (Ed.) C.C. Thomas, Springfield, I11., 1964.Google Scholar
  8. 8.
    Smith, S., Watts, R. and Dils, R. J.Lipid Res. 9: 52 (1968).PubMedGoogle Scholar
  9. 9.
    Rees, E.D., Shuck, A.E. and Ackermann, H. Froc.Soc.Exp.Biol. Med. (in press).Google Scholar
  10. 10.
    Sterental, A., Dominguez, J.M., Weissman, C., and Pearson, O.H. Cancer Res. 23: 481 (1963).PubMedGoogle Scholar
  11. 11.
    Jabara, A.G. Brit.J.Cancer 21: 418(1967).PubMedCrossRefGoogle Scholar
  12. 12.
    Huggins, C., and Yang, B.C. Science 137: 257 (1962).Google Scholar
  13. 13.
    Teller, H., Stock, C.C., and Bowie, M. Cancer Res. 26: 2329 (1966).PubMedGoogle Scholar
  14. 14.
    Ercoli, A. and Briziarelli, G. J.Nat.Cancer Instit. 27: 1173 (1961).Google Scholar
  15. 15.
    Heise, E. and Görlich, M. Brit.J.Cancer 20: 539 (1966).PubMedCrossRefGoogle Scholar
  16. 16.
    Teller, M.N., Kaufman, R.J., Stock, C.C. and Bowie, M. Cancer Res. 28: 368 (1968).PubMedGoogle Scholar
  17. 17.
    Kim, U. and Fürth, J. Proc.Soc.Exp.Biol.Med. 103: 643 (1960).PubMedGoogle Scholar
  18. 18.
    Young, S. and Cowan, D.M. Brit.J.Cancer 27: 85 (1963).CrossRefGoogle Scholar
  19. 19.
    Shimkin, M., Gropper, R., Thatcher, D. and Gruenstein, M. Cancer Res. 27: 11 (1967).Google Scholar
  20. 20.
    McCoraick, G.M. and Moon, R.C. Cancer Res. 27: 626 (1967).Google Scholar
  21. 21.
    Dao, T.L., Bock F.G., and Greiner, M.J. J.Nat.Cancer Instit. 25: 991 (1960).Google Scholar
  22. 22.
    Shay, H., Gruenstein, M. and Shimkin, M.B. Cancer Res. 24: 998 (1964).PubMedGoogle Scholar
  23. 23.
    Mobbs, B.G. J.Endocrin. 36: 409 (1966).CrossRefGoogle Scholar
  24. 24.
    Gorski, J. and Axman, M.C. Arch.Biochem.Biophys. 105: 517 (1964).PubMedCrossRefGoogle Scholar
  25. 25.
    Robinson, D.S. and Harris, P.M. Biochem.J. 80: 361 (1961).PubMedGoogle Scholar
  26. 26.
    Teller, M.N., Stock, C.C, Stohr, G., Merker, P.C., Kaufman, R.J., Escher, G.C. and Bowie, M. Cancer Res. 26: 245 (1966).PubMedGoogle Scholar
  27. 27.
    Doering, C.H. and Natori, Y. Proc.Soc.Exp.Biol.Med. 118: 957 (1965).PubMedGoogle Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • E. Douglas Rees
    • 1
  1. 1.Departments of Medicine and Pharmacology and the Clinical Research CenterUniversity of KentuckyLexingtonUSA

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