Effects of Estradiol-17β and Progesterone on Experimental Mammary Carcinoma Lipid
Like the parent mammary epithelium, many of the mammary carcinomas induced by the polycyclic hydrocarbons, 3-methylcholanthrene (3-MC) and 7,12-dimethylbenz(a)anthracene (DMBA), respond to hormonal changes in the host. Two kinds of responsiveness have been demonstrated: a) regression after ovariectomy, and b) lipid accumulation following high doses of estradiol-17β with or without progesterone. Shay et al (1,2) showed the frequent occurrence of mammary carcinomas in the Wistar rat following intragastric administration of 3-MC dissolved In olive oil, and they also demonstrated that the carcinomas regress after ablation of the ovaries. Huggins and his associates (3,4) later discovered the marked sensitivity of the breast tissue of the young, female Sprague-Dawley rat to 3-MC and DMBA. Dose schedules have been worked out by Huggins so that mammary carcinomas now can be induced with virtual certainty in 1007. of these animals. Most of the animals bear several tumors and though some tumors may become very large (100 gms or more), the hosts generally survive for several months. Most of the carcinomas are strikingly hormone dependent in that they regress rapidly after ovariectomy or hypophysectomy.
KeywordsMammary Gland Lipid Accumulation Mammary Carcinoma Uterine Weight Fatty Acid Synthetase
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