Advertisement

The Regulation of Cyclic AMP and Lipolysis in Adipose Tissue by Hormones and Other Agents

  • R. W. Butcher
  • C. E. Baird
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)

Abstract

Lipolysis in fat cells is regulated at least in part by the intracellular levels of adenosine 3′,5′-monophosphate (cyclic AMP) (1, 2). Cyclic AMP levels in fat cells are increased or decreased by several hormones and chemical agents. The relationships between such agents, cyclic AMP, and lipolysis are illustrated in Fig. 1.

Keywords

Adipose Tissue Nicotinic Acid Adenyl Cyclase Methyl Xanthine Triglyceride Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Butcher, R. W., Ho, R. J., Meng, H. C. and Sutherland, E. W. J. Biol. Cherru 240:4515 (1965).Google Scholar
  2. 2.
    Butcher, R. W. and Sutherland, E. W. Ann. N. Y. Acad. Sci. 139:849 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    Robison, G. A., Butcher, R. W. and Sutherland, E. W. In Annual Review of Biochemistry. Edited by P. D. Boyer. Annual Reviews Inc. P. 149 (1968).Google Scholar
  4. 4.
    Butcher, R. W. Baird, C. E., and Sutherland, E. W. J. Biol. Chem. 243:1705 (1968).PubMedGoogle Scholar
  5. 5.
    Butcher, R. W. and Sutherland, E. W. J. Biol. Chem. 237: 1244 (1962).Google Scholar
  6. 6.
    Appleman, M. M., Kemp, R. G., Perry, J. and Sorenson, R. Biochem. Biophys. Res. Commun. 24:564 (1966).PubMedCrossRefGoogle Scholar
  7. 7.
    Cheung, W. Y. Biochemistry 6:107 9 (1967).Google Scholar
  8. 8.
    Butcher, R. W. and Baird, C. E. J. Biol. Chem. 243: 1713 (1968).Google Scholar
  9. 9.
    Butcher, R. W., Sneyd, J. G. T., Park, C. R. and Sutherland, E. W., Jr. J. Biol. Chem. 241:1651 (1966).PubMedGoogle Scholar
  10. 10.
    Vaughan, M. and Steinberg, D. In Handbook of Physiology, Section 5: Adipose Tissue. Edited by A. S. Renold and G. F. Cahill, Jr. Washington, D. C.: American Physiological Society. P. 239 (1965).Google Scholar
  11. 11.
    Aulich, A., Stock, K and Westermann, E. Life Sciences 6: 929 (1967).PubMedCrossRefGoogle Scholar
  12. 12.
    Weiss, B., Davies, J. L and Brodie, B. B. Biochem. Pharmacol. 15:1553 (1966).PubMedCrossRefGoogle Scholar
  13. 13.
    Rizack, M. A. J. Biol. Chem. 239:392 (1964).Google Scholar
  14. 14.
    Hales, C. N., Chalmers, T. M., Perry, M. C. and Wade, D. R. In Protein and Polypeptide Hormones, Part 2. Edited by M. Margoulies. Belgium: Excerpta Medica Foundation. P. 432 (1968).Google Scholar
  15. 15.
    Walsh, D. A., Perkins, J. P. and Krebs, E. G. J. Biol. Chem. 243:3763 (1968).Google Scholar
  16. 16.
    Mansour, T. E. J. Biol. Chem. 240:2165 (1965).Google Scholar
  17. 17.
    Birnbaumer, L. and Rodbell, M. In Protein and Polypeptide Hormones, Part 3. Edited by M. Margoulies. Belgium: Excerpta Medica Foundation. In press.Google Scholar
  18. 18.
    Robison, G. A., Butcher, R. W. and Sutherland, E. W. Ann. N. Y. Acad. Sci. 139:7 03 (1967).Google Scholar
  19. 19.
    Gerhart, J. C. and Schachman, H. K. Biochemistry 4: 1054 (1965).PubMedCrossRefGoogle Scholar
  20. 20.
    Sutherland, E. W., Rall, T. W. and Menon, T. J. Biol. Chem. 237:1220 (1962).Google Scholar
  21. 21.
    DeRobertis, E., DeLores Arnaiz, G. R. and Alberici, M., Butcher, R. W. and Sutherland, E. W. J. Biol. Chem. 242: 3487 (1967).Google Scholar
  22. 22.
    Jungas, R. L. and Ball, E. G. Biochemistry 2:383 (1963).CrossRefGoogle Scholar
  23. 23.
    Corbin, J. D., Sneyd, J. G. T. and Park, C. R. In preparation.Google Scholar
  24. 24.
    Bergström, S., Carlson, L. A. and Weeks, J. Pharm. Rev. 20:1 (1968).PubMedGoogle Scholar
  25. 25.
    Rodbell, M. J. Biol. Chem. 239:375 (1964).Google Scholar
  26. 26.
    Robison, G. A. Personal communication.Google Scholar
  27. 27.
    Ramwell, P. R. and Shaw, J. E. In Proceedings of the Second Nobel Symposium. Edited by S. Bergström and B. Samuelson. New York: Interscience Publishers. P. 283 (1967).Google Scholar
  28. 28.
    Bergstrom, S. Science 157:382 (1967).PubMedCrossRefGoogle Scholar
  29. 29.
    Carlson, L. A. and Bally, P. R. In Handbook of Physiology, Section 5: Adipose Tissue. Edited by A. S. Renold and G. F. Cahill, Jr. Washington, D. C.: American Physiological Society. P. 557 (1965).Google Scholar
  30. 30.
    Krishna, G., Weiss, B., Davies, J. L and Hynie, S. Fed. Proc. 25:719 (1966).Google Scholar
  31. 31.
    Kupiecki, F. P. and Marshall, N. B. J. Pharm. Exp. 160: 166 (1968).Google Scholar
  32. 32.
    Mosinger, B. and Vaughan, M. Biochim. Biophys. Acta 144:569 (1967).PubMedGoogle Scholar
  33. 33.
    Mosinger, B. and Vaughan, M. Biochim. Biophys. Acta 144:556 (1967).PubMedGoogle Scholar
  34. 34.
    Bally, P. R. and Tilbury, K. L. In Protein and Polypeptide Hormones, Part 1. Edited by M. Margoulies. Belgium: Excerpta Medica Foundation. P. 154 (1968).Google Scholar
  35. 35.
    Triner, L. and Nahas, G. G. Science 150:1725 (1965).Google Scholar
  36. 36.
    Fain, J. N., Galton, D. J. and Kovacev, V. P. Molec. Pharmacol. 2:237 (1966).Google Scholar
  37. 37.
    Fain, J. N. Endocrinol. 82:825 (1968).CrossRefGoogle Scholar
  38. 38.
    Fisher, J. N. and Ball, E. G. Biochemistry 6:637 (1967).CrossRefGoogle Scholar
  39. 39.
    Krishna, G., Hynie, S. and Brodie, B. B. Proc. Natl. Acad. Sci., U. S. 59:884 (1968).PubMedCrossRefGoogle Scholar
  40. 40.
    Goodman, H. M. Endocrinology 82:1027 (1968).Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • R. W. Butcher
    • 1
    • 2
  • C. E. Baird
    • 1
  1. 1.Department of Physiology, School of MedicineVanderbilt UniversityNashvilleUSA
  2. 2.Howard Hughes Medical InstituteUSA

Personalised recommendations