The Effects of 5-Methylpyrazole-3-Carboxylic Acid (U-19,425) and Nicotinic Acid (NA) on Free Fatty Acids (FFA), Triglycerides (TG) and Cholesterol in Man

  • Kare Gundersen
  • H. V. Demissianos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 4)


U-19,425 has been shown to have a profound effect on serum FFA in animals (1). We therefore have performed a series of experiments in man to substantiate this activity, and to compare this effect with that of nicotinic acid (NA). Although the two compounds are similar in several respects, such as their initial influence on FFA and TG, and the nature of their side effects, some rather striking differences were seen.


Free Fatty Acid Nicotinic Acid Free Fatty Acid Level Serum Free Fatty Acid Rebound Phenomenon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gerritsen, G. C., Dulin, W. E., and Kupiecki, F. P. Published elsewhere in this volume.Google Scholar
  2. 2.
    Carlson, L. A. and Oro, L. J. Atheroscler. Res., 5:436–439 (1965)CrossRefGoogle Scholar
  3. 3.
    Parsons, W. B., Jr. Circulation, 24:1099.1961Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Kare Gundersen
    • 1
  • H. V. Demissianos
    • 1
  1. 1.The Upjohn CompanyKalamazooUSA

Personalised recommendations