The Effects of 5-Methylpyrazole-3-Carboxylic Acid (U-19,425) and Nicotinic Acid (NA) on Free Fatty Acids (FFA), Triglycerides (TG) and Cholesterol in Man
U-19,425 has been shown to have a profound effect on serum FFA in animals (1). We therefore have performed a series of experiments in man to substantiate this activity, and to compare this effect with that of nicotinic acid (NA). Although the two compounds are similar in several respects, such as their initial influence on FFA and TG, and the nature of their side effects, some rather striking differences were seen.
KeywordsFree Fatty Acid Nicotinic Acid Free Fatty Acid Level Serum Free Fatty Acid Rebound Phenomenon
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