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Drugs Affecting Lipid Metabolism pp 125–134Cite as

Studies of the Mechanism of Prevention of Fatty Livers by the Administration of Adenosine Triphosphate

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 4))

Abstract

Administration of large doses of adenosine triphosphate (ATP) can protect rats against the fatly liver produced by ethionine1,2,3 carbon tetrachloride3 (CCl4), azaserine3, ethanol4 and puromycin5. In considering the possible mechanisms involved in this protection, Hyams et al 3. suggested that suppression of free fatty acid (FFA) mobilisation was a major factor, but the possibility that hypothermia played a part, at least in the case of CCl4 toxicity, could not be excluded.

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References

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Author information

Authors and Affiliations

  1. Chesterton Hospital, Cambridge, England

    D. E. Hyams, A. Bizzi & A. Lietti

  2. Mario Negri Institute of Pharmacological Research, Milan, Italy

    S. Garattini

Authors
  1. D. E. Hyams
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  2. A. Bizzi
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  3. A. Lietti
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  4. S. Garattini
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Department of Geriatrics, Faculty of Medicine, University of Uppsala, Uppsala, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  3. King Gustaf Vth Research Institute, Stockholm, Sweden

    Lars A. Carlson (Professor and Chairman) (Professor and Chairman)

  4. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1969 Plenum Press

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Hyams, D.E., Bizzi, A., Lietti, A., Garattini, S. (1969). Studies of the Mechanism of Prevention of Fatty Livers by the Administration of Adenosine Triphosphate. In: Holmes, W.L., Carlson, L.A., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6866-7_12

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  • DOI: https://doi.org/10.1007/978-1-4615-6866-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6868-1

  • Online ISBN: 978-1-4615-6866-7

  • eBook Packages: Springer Book Archive

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