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Dermatologic Manifestations of Infection in the Compromised Host

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Clinical Approach to Infection in the Compromised Host

Abstract

Among the most formidable challenges to the clinician is the care of the patient with an impaired immune system—the compromised host.1–4 Two characteristics in particular contribute to the complexity of management of infection in these patients: the exceptionally broad variety of potential microbial pathogens, and the wide spectrum of clinical manifestations of disease resulting from the abnormal immune response.5–7

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References

  1. Hill RB, Dahrling BE, Starzl TE, et al: Editorial: Death after transplantation. Am J Med 42: 327–334, 1967.

    Article  PubMed  Google Scholar 

  2. Anderson RJ, Schafer LA, Olin DB,: Infectious risk factors in the immunosuppressed host. Am J Med 54: 453460, 1973.

    Google Scholar 

  3. Rubin RH, Young LS (eds). Clinical Approach to Infection in the Compromised Host. Plenum, New York, 1981.

    Google Scholar 

  4. Klastersky J (ed): Infections in Cancer Patients. European Organization for Research on Treatment of Cancer Monograph Series. Vol 10. Raven, New York, 1982.

    Google Scholar 

  5. Dale DC, Petersdorf RG: Corticosteroids and infectious diseases. Med Clin. North Am. 57: 1277–1287, 1973.

    CAS  Google Scholar 

  6. Dale DC. Defects in host defense mechanisms in compromised patients. In Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host. Plenum, New York, 1981, pp. 35–74.

    Google Scholar 

  7. Wiernik PH. The management of infection in the cancer patient. JAMA 244: 185–192, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Haim S, Freidman-Birnbaum R, Better O, et al: Skin complications in immunosuppressed patients: Follow-up of kidney recipients. Br J Dermatol 89: 169–173, 1973.

    Article  PubMed  CAS  Google Scholar 

  9. Koranda F, Dehmel E, Kahn G, Penn I: Cutaneous complications in immunosuppressed renal homograft recipients. JAMA 229: 419–424, 1974.

    Article  PubMed  CAS  Google Scholar 

  10. Savin JA, Nobel WC: Immunosuppression and skin infection. Br J Dermatol 93: 115–120, 1975.

    Article  PubMed  CAS  Google Scholar 

  11. Rubin RH: Infection in the renal transplant patient. In Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host Plenum, New York, 1981, pp. 553606.

    Google Scholar 

  12. Wolfson JS, Sober AJ, Rubin RH: Dermatologie manifestations of infection in the compromised host. Annu. Rev. Med. 34: 205–217, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Wolfson JS, Sober AJ, Rubin RH: Dermatologic manifestations of infections in immunocompromised patients. Medicine (Baltimore) 64: 115–133, 1985.

    CAS  Google Scholar 

  14. Ray TL: Cutaneous signs of systemic disease: Fungal infections in the immunocompromised host. Med Clin North Am 64: 955–968, 1980.

    PubMed  CAS  Google Scholar 

  15. Eickhoff T, Olin B, Anderson R, et al: Current problems and approaches to diagnosis of infection in renal transplant recipients. Transplant Proc 4: 613–697, 1972.

    Google Scholar 

  16. Notter D, Grossman P, Rosenberg S, et al: Infections in patients with Hodgkin’s disease: A clinical study of 300 consecutive adult patients. Rev Infect Dis 2: 761–800, 1980.

    Article  PubMed  CAS  Google Scholar 

  17. Bishop T, Schimpff S, Diggs C, et al: Infections during intensive chemotherapy for non-Hodgkins lymphoma. Ann Intern Med 95: 549–555, 1981.

    PubMed  CAS  Google Scholar 

  18. Weinberg AN, Swartz MN: General considerations of bacterial diseases. Fitzpatrick TB, Eisen AZ, Wolff K, (eds): In Dermatology in General Medicine. McGraw-Hill, New York, 1979, pp. 1415–1426.

    Google Scholar 

  19. Prystowsky S, Vogelstein B, Ettinger D, et al: Invasive aspergillosis. N Engl J Med 295: 655–658, 1976.

    Article  PubMed  CAS  Google Scholar 

  20. Carlile JR, Millet RE, Cho CT, et al: Primary cutaneous aspergillosis in a leukemic child. Arch Dermatol 114:7880, 1978.

    Google Scholar 

  21. Gartenberg G, Bottone E, Keusch G, et al: Hospital-acquired mucormycosis (Rhizopus rhizopodiformis) of skin and subcutaneous tissue. N Engl J Med 299:1115–1118, 1978.

    Google Scholar 

  22. Keys T, Haldorson A, Rhodes K, et al: Nosocomial outbreak of Rhizopus infections associated with Elastoplast wound dressings-Minnesota. MMWR 27: 33–34, 1978.

    Google Scholar 

  23. Sheldon DL, Johnson WC: Cutaneous mucormycosis: Two documented cases of suspected nosocomial cause. JAMA 241:1032–1034, 1979.

    Google Scholar 

  24. Dennis JE, Rhodes KH, Cooney DR,: Nosocomial Rhizopus infection (zygomycosis) in children. J Pediatr 96:824–828, 1980.

    Google Scholar 

  25. Biro L Gibbs RC, Leider M: Staphylococcal infections. A study of incidence on a dermatologie ward. Arch Dermatol 82:205–211, 1960

    Google Scholar 

  26. Grossman ME, Fithian EC, Behrens C, et al: Primary cutaneous aspergillosis in six leukemic children. J Am Acad Dermatol 12: 313–318, 1985.

    Article  PubMed  CAS  Google Scholar 

  27. Granstein RD, First LR, Sober M: Primary cutaneous aspergillosis in a premature neonate. Br J Dermatol 103:681684,1980.

    Google Scholar 

  28. Lorenzen I: The effects of glucocorticoids on connective tissue. Acta Med Scand (Suppl.) 50:17–21, 1969.

    Google Scholar 

  29. Smithers DW: Hodgkin’s disease. II. Br Med J 2: 337–340, 1967.

    Article  PubMed  CAS  Google Scholar 

  30. Mullen DL, Silverberg SG, Penn I, et al: Squamous cell carcinoma of the skin and lip in renal homograft recipients. Cancer 37: 729–734, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Hersh EM, Freireich EJ: Focus on cutaneous host-defense failure in transplant recipients. JAMA 229: 457–458, 1974.

    Article  PubMed  CAS  Google Scholar 

  32. Spencer ES, Anderson HK: Clinically evident, non-terminal infections with herpes viruses and the wart virus in immunosuppressed renal allograft recipients. Br Med J 3:251–254, 1970.

    Google Scholar 

  33. Hardie IR, Strong RW, Hartley CJ, et al: Skin cancer in Caucasian renal allograft recipients living in a subtropical climate. Surgery 87:177–183, 1980.

    Google Scholar 

  34. Lutzner MA, Orth G, Dutronquay V, et al: Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lancet 2: 42 2424, 1983.

    Google Scholar 

  35. Dolin’R, Reichman RC, Mazur MH.: NIH Conference: Herpes zoster-varicella infections in immunosuppressed patients. Ann Intern Med 89: 375–388, 1978.

    Google Scholar 

  36. Hirsch MS: Herpes group virus infections in the compromised host. In Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host. Plenum, New York, 1981, pp. 389–415.

    Google Scholar 

  37. Siegel FP, Lopez C, Hammer GS,: Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305:1439–1444, 1981.

    Google Scholar 

  38. Gottlieb MS, Groopman JE, Weinstein WM, et al: UCLA Conference: The acquired immunodeficiency syndrome. Ann Intern Med 99: 208–220, 1983.

    PubMed  CAS  Google Scholar 

  39. Chou S, Gallagher JG, Merigan TC: Controlled clinical trial of intravenous acyclovir in heart-transplant patients with mucocutaneous herpes simplex infection. Lancet 1: 1392 1394, 1981.

    Google Scholar 

  40. Mitchell CD, Bean B, Gentry SR, et al: Acyclovir therapy for mucocutaneous herpes simplex infections in immunocompromised patients. Lancet 1:1389–1392, 1981.

    Google Scholar 

  41. Straus SE, Smith HA, Brickman C, et al: Acyclovir for chronic mucocutaneous herpes simplex virus infection in immunosuppressed patients. Ann Intern Med 96: 270–277, 1982.

    PubMed  CAS  Google Scholar 

  42. Wade JC, Newton B, McLaren C, et al: Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: A double-blind trial. Ann Intern Med 96: 265–269, 1982.

    PubMed  CAS  Google Scholar 

  43. Hirsch MS, Schooley RT: Treatment of herpesvirus infections. N Engl J Med 309: 963–970, 1034–1039, 1983.

    Google Scholar 

  44. Whitley RJ, Levin M, Barton N, et al: Infections caused by herpes simplex virus in the immunocompromised host: Natural history and topical acyclovir therapy. J Infect Dis 150:323–329, 1984.

    Google Scholar 

  45. Wong KK, Hirsch MS: Herpes virus infections in patients with neoplastic disease. Diagnosis and therapy. Am J Med 76: 464–478, 1984.

    Article  PubMed  CAS  Google Scholar 

  46. Schimpff S, Serpick A, Stoler B, et al: Varicella-zoster infection in patients with cancer. Ann Intern Med 76:241–254, 1972.

    Google Scholar 

  47. Meyers JD, Thomas ED: Infection complicating bone marrow transplantation. In Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host. Plenum, New York, 1981, pp. 507–551.

    Google Scholar 

  48. Balfour HH, Bean B, Laskin OL, et al: Acyclovir halts progression of herpes zoster in immunocompromised patients. N Engl J Med 308:1448–1453, 1983.

    Google Scholar 

  49. Alteras I, Aryeli G, Feuerman EJ: The prevalence of pathogenic and potentially pathogenic fungi on the apparently healthy skin of patients with neoplastic diseases. Mycopathologia 71: 85–87, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Manzella JP, Berman IJ, Kukrilca MD: Trichosporon beigelii fungemia and cutaneous dissemination. Arch Dermatol 118:343–345, 1982.

    Google Scholar 

  51. Horsburgh CR, Kirkpatrick CH: Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: Experience with 21 patients. Am J Med 74: 23–29, 1983.

    Article  PubMed  Google Scholar 

  52. Dismukes WE, Stamm AM, Graybill JR, et al: Treatment of systemic mycoses with ketaconazole: Emphasis on toxicity and clinical response in 52 patients. Ann Intern Med 98:1320, 1983.

    Google Scholar 

  53. Uys CT, Don PA, Schire V,: Endocarditis following cardiac surgery due to the fungus Paecilomyces. S Afr Med J 37:1276–12801963.

    Google Scholar 

  54. Silver MD, Tuffnell PG, Bigelow WG: Endocarditis caused by Paecilomyces varioti affecting an aortic valve allograft. J Thorac Cardiovasc Surg 61: 278–281, 1971.

    PubMed  CAS  Google Scholar 

  55. Haldane EV, MacDonald JL, Gittens WO, et al: Prosthetic valvular endocarditis due to the fungus Paecilomyces. Can Med Assoc J 111: 963–968, 1974.

    CAS  Google Scholar 

  56. McClellan JR, Hamilton JD, Alexander JA,: Paecilomyces varioti endocarditis on a prosthetic valve. J Thorac Cardiovasc Surg 71: 472–475, 1976.

    PubMed  CAS  Google Scholar 

  57. Mosier MA, Lusk B, Pettit TH, et al: Fungal endophthalmitis following intraocular lens implantation. Am J Ophthalmol 83:1–8, 1977.

    Google Scholar 

  58. O’Day DM: Fungal endophthalmitis caused by Paecilomyces lilacinus after intraocular lens implantation. Am J Ophthalmol 83:130–131, 1977.

    Google Scholar 

  59. Harris LF, Dan BM, Lefkowitz LB,: Paecilomyces cellulitis in a renal transplant patient: Successful treatment with intravenous miconazole. South Med J 72: 897–898, 1979.

    Article  PubMed  CAS  Google Scholar 

  60. Fogan L: Atypical mycobacteria. Medicine (Baltimore) 49:243–255, 1970.

    Google Scholar 

  61. Kaplan MH, Armstrong D, Rosen P: Tuberculosis complicating neoplastic disease. Cancer 33: 850–858, 1974.

    Article  PubMed  CAS  Google Scholar 

  62. Wolinsky E: Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 119:107–158, 1979.

    Google Scholar 

  63. Beyt BE, Ortbals DW, Santa Cruz DJ, et al: Cutaneous mycobacteriosis: Analysis of 34 cases with a new classification of the disease. Medicine (Baltimore) 60: 95–109, 1981.

    Google Scholar 

  64. Lloveras J, Peterson PK, Simmons RL, et al: Mycobacterial infections in renal transplant recipients: Seven cases and a review of the literature. Arch Intern Med 142: 888–892, 1982.

    Article  PubMed  CAS  Google Scholar 

  65. Lichtenstein IH, MacGregor RR: Mycobacterial infections in renal transplant recipients: Report of five cases and review of the literature. Rev Infect Dis 5: 216–226, 1983.

    Article  PubMed  CAS  Google Scholar 

  66. Grice, K: Sarcoidosis and Mycobacterium avium-intracellulare cutaneous abscesses. Clin Exp Dermatol 8: 323327, 1983.

    Google Scholar 

  67. Wallace RJ, Swenson JM, Silcox VA, et al: Spectrum of disease due to rapidly growing mycobacteria. Rev Infect Dis 5: 657–679, 1983.

    Article  PubMed  Google Scholar 

  68. Davis BR, Brumback J, Sanders WJ, et al: Skin lesions caused by Mycobacterium haemophilum. Ann Intern Med 97: 723–724, 1982.

    CAS  Google Scholar 

  69. Gombert ME, Goldstein EJC, Corrado ML, et al: Disseminated Mycobacterium marinum infection after renal transplantation. Ann Intern Med 94: 486–487, 1981.

    PubMed  CAS  Google Scholar 

  70. Davies RR, Wilkinson JL: Human protothecosis: Supplementary studies. Ann Trop Med Parasitol 61:112–115, 1967.

    Google Scholar 

  71. Tindall JP, Fetter BF: Infections caused by achloric algae (protothecosis). Arch Dermatol 104: 490–500, 1971.

    Article  PubMed  CAS  Google Scholar 

  72. Cox GE, Wilson JD, Brown P: Protothecosis: A case of disseminated algal infection. Lancet 2: 379–382, 1974.

    PubMed  CAS  Google Scholar 

  73. Sudman MS: Protothecosis: A critical review. Am J Clin Pathol 61: 10–19, 1974.

    PubMed  CAS  Google Scholar 

  74. Mayhall CG, Miller CW, Eisen AZ, et al: Cutaneous protothecosis: Successful treatment with amphotericin B. Arch Dermatol 112:1749–1752, 1976.

    Google Scholar 

  75. Wolfe ID, Sacks HG, Samorodin CS, et al: Cutaneous protothecosis in a patient receiving immunosuppressive therapy. Arch Dermatol 112: 829–832, 1976.

    Article  PubMed  CAS  Google Scholar 

  76. Dagher FJ, Smith AG, Pankoski D, et al: Skin protothecosis in a patient with renal allograft. South Med J 71: 222–224, 1978.

    Article  PubMed  CAS  Google Scholar 

  77. Phair JP, Williams JE, Bassaris HP, et al: Phagocytosis and algicidal activity of human polymorphonuclear neutrophils against Prototheca wickerhamii. J Infect Dis 144: 72–76, 1981.

    Article  CAS  Google Scholar 

  78. Venezio FR, Lavoo E, Williams JE, et al: Progressive cutaneous protothecosis. Am J Clin Pathol 77: 485–493, 1982.

    PubMed  CAS  Google Scholar 

  79. Pegram PS, Kerns FT, Wasilauskas BL, et al: Successful ketoconazole treatment of protothecosis with ketoconazoleassociated hepatotoxicity. Arch Intern Med 143:1802–1805, 1983.

    Google Scholar 

  80. Vernon SE, Goldman LS: Protothecosis in the Southeastern United States. South Med J 76: 949–950, 1983.

    Article  PubMed  CAS  Google Scholar 

  81. Klintworth GK, Fetter BF, Nielsen HS: Protothecosis: An algal infection: Report of a case in man. J Med Microbiol 1: 211–216, 1968.

    Article  PubMed  CAS  Google Scholar 

  82. Langlois RP, Flegel KM, Meakins JL, et al: Cutaneous aspergillosis with fatal dissemination in a renal transplant recipient. Can Med J 22: 673–676, 1980.

    Google Scholar 

  83. Lehrer RI, Howard DH, Sypherd PS, et al: UCLA conference: Mucormycosis. Ann Intern Med 93: 93–108, 1980.

    Google Scholar 

  84. Fisher J, Tuazon CU, Geelhoed GW: Mucormycosis in transplant patients. Am Sur 46:315–322, 1980.

    Google Scholar 

  85. Bateman CP, Umland ET, Becker LE: Cutaneous zygomycosis in a patient with lymphoma. J Am Acad Dermatol 8: 890–894, 1983.

    Article  PubMed  CAS  Google Scholar 

  86. Young RC, Bennett JE, Vogel CL, et al: Aspergillosis: The spectrum of the disease in 98 patients. Medicine (Baltimore) 49:147–173, 1970.

    Google Scholar 

  87. Meyer RD, Rosen P, Armstrong D: Phycomycosis complicating leukemia and lymphoma. Ann Intern Med 77:871879,1972.

    Google Scholar 

  88. Forkner CE, Frei E, Edgecomb JH, et al: Pseudomonas septicemia: Observations on twenty-three cases. Am J Med 25: 877–889, 1968.

    Article  Google Scholar 

  89. Greene SL, Su WP, Muller SA: Ecthyma gangranosum: Report of clinical, histopathologic, and bacteriologic aspects of eight cases. J Am Acad Dermatol 11:781–787. 1984.

    Google Scholar 

  90. Park RK, Goltz RW, Carey TB: Unusual cutaneous infections associated with immunosuppressive therapy. Arch Dermatol 95: 345–350, 1967.

    Article  PubMed  CAS  Google Scholar 

  91. O’Dorisio TM, Jasper DA, Sullivan J: A cutaneous manifestation of untreated disseminated histoplasmosis. Chest 67: 616–617, 1975.

    Article  PubMed  Google Scholar 

  92. Studdard J, Sneed WF, Taylor MR, et al: Cutaneous histoplasmosis. Am Rev Respir Dis 113: 689–693, 1976.

    PubMed  CAS  Google Scholar 

  93. Daman LA, Hashimoto K, Kaplan RJ, et al: Disseminated histoplasmosis in an immunosuppressed patient. South Med J 70: 355–356, 1977.

    Article  PubMed  CAS  Google Scholar 

  94. Cott GR, Smith TW, Hinthom DR, et al: Primary cutaneous histoplasmosis in immunosuppressed patients. JAMA 242: 456–457, 1979.

    Article  PubMed  CAS  Google Scholar 

  95. Johnston CA, Tang CK, Jiji R: Histoplasmosis of skin and lymph nodes and chronic lymphocytic leukemia. Arch Dermatol 115: 336–337, 1979.

    Article  PubMed  CAS  Google Scholar 

  96. Davies SR, Sarosi GA, Peterson PK, et al: Disseminated histoplasmosis in renal transplant recipients. Am J Surg 137: 686–691, 1979.

    Article  PubMed  CAS  Google Scholar 

  97. Goodwin RA, Shapiro JL, Thurman GH, et al: Disseminated histoplasmosis: Clinical and pathologic correlations. Medicine (Baltimore) 59:1–33, 1980.

    Google Scholar 

  98. Farr B, Beacham BE, Atuk NO: Cutaneous histoplasmosis after renal transplantation. South Med J 74:635–637, 1981.

    Google Scholar 

  99. Palmer DL, Harvey RL, Wheeler JK: Diagnostic and therapeutic considerations in Nocardia asteroides infection. Medicine (Baltimore) 53: 391–401, 1974.

    Article  CAS  Google Scholar 

  100. Frazier AR, Rosenow EC, Roberts GD: Nocardiosis: A review of 25 cases occurring during 24 months. Mayo Clin Proc 50:657–663, 1975.

    Google Scholar 

  101. Beaman BL, Burnside J, Edwards B,: Nocardial infections in the United States, 1972–1974. J Infect Dis 134:286289,1976.

    Google Scholar 

  102. Brown E, Freedman S, Arbeit R, et al: Invasive pulmonary aspergillosis in an apparently non-immunocompromised host. Am J Med 69: 624–627, 1980.

    Article  PubMed  CAS  Google Scholar 

  103. Fisher BD, Armstrong D, Yu B, et al: Invasive aspergillosis: Prognosis in early diagnosis and treatment. Am J Med 71: 571–577, 1981.

    Article  PubMed  CAS  Google Scholar 

  104. Kerkering TM, Duma RJ, Shadomy S: The evolution of pulmonary cryptococcosis. Ann Intern Med 94: 611–616, 1981.

    PubMed  CAS  Google Scholar 

  105. Myskowski PL, Brown AE, Dinsmore R,: Mucor-mycosis following bone marrow transplantation. J Am Acad Dermatol 9: 111–115, 1983.

    Google Scholar 

  106. Perfect JR, Durack DT, Gallis HA: Cryptococcemia. Medicine (Baltimore) 62: 98–109, 1983.

    CAS  Google Scholar 

  107. Rinaldi MG: Invasive aspergillosis. Rev Infect Dis 5: 1061 1077, 1983.

    Google Scholar 

  108. Sarosi GA, Silberfarb PM, Tosh FE: Cutaneous cryptococcosis: A sentinel of disseminated disease. Arch Dermatol 104:1–3, 1971.

    Google Scholar 

  109. Meyer RD, Kaplan MH, Ong M, et al: Cutaneous lesions in disseminated mucormycosis. JAMA 225: 737–738, 1973.

    Article  PubMed  CAS  Google Scholar 

  110. Schupbach CW, Wheeler CE, Briggaman RA, et al: Cutaneous manifestations of disseminated cryptococcosis. Arch Dermatol 112:1734–1740, 1976.

    Google Scholar 

  111. Kramer BS, Hernandez AD, Reddick RL, et al: Cutaneous infarction: Manifestation of disseminated mucormycosis. Arch Dermatol 113:1075–1076, 1977.

    Google Scholar 

  112. Greene MH, Macher AM, Hernandez AD, et al: Disseminated cryptococcosis presenting as palpable purpura. Arch Intern Med 138:1412–1413, 1978.

    Google Scholar 

  113. Simpson GL, Stinson EB, Egger MJ, et al: Nocardial infections in the immunocompromised host: A detailed study in a defined population. Rev Infect Dis 3: 492–507, 1981.

    Article  PubMed  CAS  Google Scholar 

  114. Bernhardt MJ, Ward WQ, Sams WM: Cryptococcal cellulitis. Cutis 34: 359–361, 1984.

    PubMed  CAS  Google Scholar 

  115. Bodey GP, Luna M: Skin lesions associated with disseminated candidiasis. JAMA 229:1466–1468, 1974.

    Google Scholar 

  116. Wingard JR, Merz WG, Saral R: Candida tropicalis: A major pathogen in immunocompromised patients. Ann Intern Med 91:539–543, 1979.

    Google Scholar 

  117. Louria DB, Stiff DP, Bennett B: Disseminated moniliasis in the adult. Medicine (Baltimore) 41: 307–337, 1962.

    Google Scholar 

  118. De Vita VT, Utz JP, Williams T, et al: Candida meningitis. Arch Intern Med 117: 527–535, 1966.

    Article  Google Scholar 

  119. Curry CR, Quie PG: Fungal septicemia in patients receiving parenteral hyperalimentation. N Engl J Med 285: 1221 1225, 1971.

    Google Scholar 

  120. Bayer AS, Edwards JE, Seidel JS, et al: Candida meningitis. Report of seven cases and review of the English literature. Medicine (Baltimore) 55: 477–486, 1976.

    Article  CAS  Google Scholar 

  121. Myerowitz RL, Pazin GJ, Allen CM: Disseminated candidiasis. Changes in incidence, underlying diseases, and pathology. Am J Clin Pathol 68: 29–38, 1977.

    PubMed  CAS  Google Scholar 

  122. Balandran L, Rothschild H, Pugh N,: A cutaneous manifestation of systemic candidiasis. Ann Intern Med 78: 400–403, 1973.

    PubMed  CAS  Google Scholar 

  123. Edwards JE, Lehrer RI, Stiehm ER, et al: UCLA Conference: Severe candidal infections: Clinical perspective, immune defense mechanisms, and current concepts of therapy. Ann Intern Med 89: 91–106, 1978.

    PubMed  Google Scholar 

  124. Jarowski CI, Fialk MA, Murray HW, et al: Fever, rash, and muscle tenderness: A distinctive clinical presentation of disseminated candidiasis. Arch Intern Med 138: 544–546, 1978.

    Article  PubMed  CAS  Google Scholar 

  125. Kressel B, Szewczyk C, Tuazon CU: Early clinical recognition of disseminated candidiasis by muscle and skin biopsy. Arch Intern Med 138: 429–433, 1978.

    Article  PubMed  CAS  Google Scholar 

  126. Grossman ME, Silvers DN, Walther RR: Cutaneous manifestations of disseminated candidiasis. J Am Acad Dermatol 2: 111–116, 1980.

    PubMed  CAS  Google Scholar 

  127. Jacobs MI, Magid MS, Jarowski Cl: Disseminated candidiasis: Newer approaches to early recognition and treatment. Arch Dermatol 116:1277–1279, 1980.

    Google Scholar 

  128. Arena FP, Perlin M, Brahman H,: Fever, rash, and myalgias of disseminated candidiasis during antifungal therapy. Arch Intern Med 141:1233 1981.

    Google Scholar 

  129. Smego RA, Gallis HA: The clinical spectrum of Nocardia brasiliensis infection in the United States. Rev Infect Dis 6:164–180, 1984.

    Google Scholar 

  130. Fauci AS, Macher AM, Longo DL, et al: NIH conference. Acquired immunodeficiency syndrome: Epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med 100: 92–106, 1984.

    PubMed  CAS  Google Scholar 

  131. Jaffe HS, Abrams DI, Ammann AJ, et al: Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet 2: 1109–1111, 1983.

    Article  PubMed  CAS  Google Scholar 

  132. Mitsuyasu R Groopman J, Volberding P: Cutaneous reaction to trimethoprim-sulfamethoxazole in patients with AIDS and Kaposi’s sarcoma. NEngl J Med 308:1535–1536 1983.

    Google Scholar 

  133. Gordin FM, Simon GL, Wofsy CB,: Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 100: 495–499, 1984.

    PubMed  CAS  Google Scholar 

  134. Ziegler JL, Beckstead JA, Volberding PA, et al: Non-Hodgkin’s lymphoma in 90 homosexual men. Relation to generalized lymphadenopathy and the acquired immunodeficiency syndrome. N Engl J Med 311: 565–570, 1984.

    Article  PubMed  CAS  Google Scholar 

  135. Lind SE, Gross PL, Andiman WA, et al: Malignant lymphoma presenting as Kaposi’s sarcoma in a homosexual man with the acquired immunodeficiency syndrome. Ann Intern Med 102: 338–340, 1985.

    PubMed  CAS  Google Scholar 

  136. Morris L, Distenfeld A, Amorosi E, et al: Autoimmune thrombocytopenic purpura in homosexual men. Ann Intern Med 96: 714–717, 1982.

    PubMed  CAS  Google Scholar 

  137. Eisenstat BA, Wormser GP: Seborrheic dermatitis and butterfly rash in AIDS. N Engl J Med 311:189, 1984.

    Google Scholar 

  138. Abramson SB, Odajnyk CM, Grieco AJ, et al: Hyperalgesic pseudothrombophlebitis. New syndrome in male homosexuals. Am J Med 78: 317–320, 1985.

    Article  PubMed  CAS  Google Scholar 

  139. Sandor E, Croxson TS, Millman A, et al: Herpes zoster ophthalmicus in patients at risk for AIDS. N Engl J Med 310: 1118–1119, 1984.

    PubMed  CAS  Google Scholar 

  140. Ho DD, Murata GH: Streptococcal lymphadenitis in homosexual men with chronic lymphadenopathy. Am J Med 77:151–153, 1984.

    Google Scholar 

  141. Holtz HA, Lavery DP, Kapila R: Actinomycetales infection in the acquired immunodeficiency syndrome. Ann Intern Med 102: 203–205, 1985.

    PubMed  CAS  Google Scholar 

  142. Macher AM, Kovars JA, Gill V, et al: Bacteremia due to Mycobacterium avium-intracellulare in the acquired immunodeficiency syndrome. Ann Intern Med 99: 782–785, 1983.

    PubMed  CAS  Google Scholar 

  143. Wilson CB, Siber GR, O’Brien TF, et al: Phycomycotic gangrenous cellulitis. Arch Surg 111: 532–538, 1976.

    Article  PubMed  CAS  Google Scholar 

  144. Lomvardias S, Madge GE: Chaetoconidium and atypical acid-fast bacilli in skin ulcers. Arch Dermatol 106:875–876, 1972.

    Google Scholar 

  145. Lewis JL, Rabinovich S: The wide spectrum of cryptococcal infections. Am J Med 53:315–322, 1972.

    Google Scholar 

  146. Cho CT, Vats TS, Lowman JT,: Fusarium solani infection during treatment for acute leukemia. JPediatr 83:10281031,1973.

    Google Scholar 

  147. Bolivar R, Salterwhite TK, Floyd M: Cutaneous lesions due to Mycobacterium kansasii. Arch Dermatol 116: 207–208, 1980.

    Article  CAS  Google Scholar 

  148. Fine JD, Miller JA, Harrist TJ,: Cutaneous lesions in disseminated candidiasis mimicking ecthyma gangrenosum. Am J Med 70: 1133–1135, 1981.

    Google Scholar 

  149. Farmer SG, Komorowski RA: Cutaneous microabscess formation from Alternaria alternata. Am J Clin Pathol 66:565569, 1976.

    Google Scholar 

  150. Moore M: Cryptococcus with cutaneous manifestations. J Invest Dermatol 28:159–182, 1957.

    Google Scholar 

  151. Heironimus JD, Winn RE, Collins CB: Cutaneous non-pulmonary Mycobacterium chelonei infection. Arch Dermatol 120:1061–1063, 1984.

    Google Scholar 

  152. Cross GM, Guill MA, Aton JK: Cutaneous Mycobacterium szulgai infection. Arch Dermatol 121: 247–249, 1985.

    Article  PubMed  CAS  Google Scholar 

  153. Apaliski SJ, Moore MD, Reiner BJ, et al: Disseminated Trichosporon beigelii in an immunocompromised child. Pediatr Infect Dis 3: 451–454, 1984.

    Article  PubMed  CAS  Google Scholar 

  154. Hernanz AD, Conde-Zurita JM, Pecharroman SR, et al: A case of Alternaria alternata (Fr.) Keissler infection of the knee. Clin Exp Dermatol 8: 641–646, 1983.

    Article  Google Scholar 

  155. Bourlond A, Alexandre G: Dermal alternariasis in a kidney transplant recipient. Dermatologica 168:152–156, 1984.

    Google Scholar 

  156. Sanderson TL, Moskowitz L, Hensley GT, et al: Disseminated Mycobacterium avium-intracellulare infection appearing as a panniculitis. Arch Pathol Lab Med 106:112114, 1982.

    Google Scholar 

  157. Zaatari GS, Reed R, Morewessel R: Subcutaneous hyphomycosis caused by Scytalidium hyalinum. Am J Clin Pathol 82:252–256 1984.

    Google Scholar 

  158. Baker RD, Seabury JH, Schneidau JD: Subcutaneous and cutaneous mucormycosis and subcutaneous phycomycosis. Lab Invest 11:1091–1102, 1962.

    Google Scholar 

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Wolfson, J.S., Sober, A.J. (1988). Dermatologic Manifestations of Infection in the Compromised Host. In: Rubin, R.H., Young, L.S. (eds) Clinical Approach to Infection in the Compromised Host. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6645-8_5

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