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Fever and Septicemia

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Clinical Approach to Infection in the Compromised Host

Abstract

Fever is the hallmark of infection but is not specific for it. Infection can begin and progress in the absence of fever. When fever occurs in the immunocompromised host, the single major challenge in clinical decision making is to ascertain whether the onset of temperature elevation is a reliable indication of the onset of infection rather than a manifestation of the underlying disease, a hypersensitivity reaction, or a factitious development. Another major issue that frequently stirs acrimonious bedside debate involves the clinical wisdom of suppressing fever with or without evidence of documented infection. Despite many decades of controversy, it has not been conclusively established whether fever is “good” for the patient or just adds to patient discomfort without benefitting host defenses against infection or the underlying disease.

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Authors and Affiliations

  1. Division of Infectious Diseases, Pacific Presbyterian Medical Center, Kuzell Institute for Arthritis and Infectious Disease, San Francisco, California, 94115, USA

    Lowell S. Young

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Editors and Affiliations

  1. Infectious Disease and Transplantation Units, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Robert H. Rubin M.D.

  2. Division of Infectious Diseases, Pacific Presbyterian Medical Center, Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA

    Lowell S. Young M.D.

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© 1988 Plenum Publishing Corporation

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Young, L.S. (1988). Fever and Septicemia. In: Rubin, R.H., Young, L.S. (eds) Clinical Approach to Infection in the Compromised Host. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6642-7_4

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