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Antitumor Effects of Interferon

  • Chapter
Chemotherapy

Part of the book series: Cancer ((C,volume 5))

Abstract

Interferon was first described in 1957 by Isaacs and Lindenmann (1957) and characterized as “an antiviral substance produced by the cells of many vertebrates in response to virus infection. It appears to be of protein or polypeptide nature, it is antigenically distinct from virus, and it acts by conferring on cells resistance to the multiplication of a number of different viruses” (Isaacs, 1963). Although this description still has some validity today, there is considerable evidence indicating that interferon is not a selective antiviral substance, but that it can also affect both cell division and cell function.

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References

  • Absher, M., and Stinebring, W. R., 1969, Endotoxin-like properties of poly I. poly C, an interferon stimulator, Nature (London) 223: 715.

    Google Scholar 

  • Adams, A., Strander, H., and Cantell, K., 1975, Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon, J. Gen. Virol. 28: 207.

    PubMed  CAS  Google Scholar 

  • Adamson, R. H., 197la, Antitumor activity of tilorone hydrochloride against some rodent tumors: Preliminary report, J. Natl. Cancer Inst. 46: 431.

    Google Scholar 

  • Adamson, R. H., 1971 b, Antitumour activity of two antiviral drugs—rifampicin and tilorone, Lancet 1: 398.

    Google Scholar 

  • ADAMSON, R. H., and TING, R. C., 1971,The antitumor activity of the interferon inducer tilorone hydrochloride, Bacteriol. Proc., p. 196.

    Google Scholar 

  • Adamson, R. H., Fabro, S., Homan, E. R., O’gara, R. W., and Zendzian, R. P., 1969, Pharmacology of polyriboinosinic: polyribocytidylic acid, a new antiviral and antitumor agent, in: Antimicrobiol Agents and Chemotherapy, p. 148, American Society of Microbiology, 1970, Bethesda, Maryland.

    Google Scholar 

  • Ahström, L., Dohlwitz, A., Strander, H., Carlström, G., and Cantell, K., 1974, Interferon in acute leukaemia in children, Lancet 1: 166.

    PubMed  Google Scholar 

  • Armstrong, M. Y. K., Black, F. L., and Richards, F. F., 1972, Tumour induction by cell-free extracts derived from mice with graft-versus-host disease, Nature (London) New Biol. 235: 153.

    CAS  Google Scholar 

  • Atanasiu, P.,and Chany, C.,1960,Action d’un interféron provenant de cellules malignes sur l’infection expérimentale du hamster nouveau-né par le virus du polyome, C. R. Acad. Sci. Paris 251: 1687.

    Google Scholar 

  • Ball, J. K., and Mccarter, J. A., 1971, Effect of polyinosinic-polycytidylic acid on induction of primary or transplanted tumors by chemical carcinogen or irradiation, J. Natl. Cancer Inst. 46: 1009.

    PubMed  CAS  Google Scholar 

  • Banks, G. T., Buck, K. W., Chain, E. B., Himmelweit, F., Marks, J. E., Tyler, J. M., Hollings, M., Last, F. T., and Stone, O. M., 1968, Viruses in fungi and interferon stimulation, Nature (London) 218: 542.

    Google Scholar 

  • Barker, A. D., Rheims, M. S.,and Wilson, H. E., 197la,Tilorone hydrochloride: Its effect on Friend virus leukemia in mice, Bacteriol. Proc.,p. 188.

    Google Scholar 

  • Barker, A. D., Rheins, M. S., and Wilson, H. E., 197lb, Amelioration of Friend virus leukemia by sequential administration of viral and nonviral interferon inducers, Proc. Soc. Exp. Biol. Med. 137: 981.

    Google Scholar 

  • Baron, S., Buckler, C. E., Mccloskey, R. V., and Kirschstein, R. L., 1966, Role of interferon during viremia, I. Production of circulating interferon, J. Immunol. 96: 12.

    PubMed  CAS  Google Scholar 

  • Baron, S., Dubuy, H., Buckler, C. E., Johnson, M. L., Park, J., Billiau, A., Sarma, P., and Huebner, R. J., 1970, Induction of interferon and viral resistance in animals by polynucleotides, Ann. N. Y. Acad. Sci. 173: 568.

    CAS  Google Scholar 

  • Barski, G., 1963, Interférence entre les virus d’herpès et de polyome chez le hamster adulte in vivo, C. R. Acad. Sci. Paris 256: 5459.

    PubMed  CAS  Google Scholar 

  • Barski, G., and Youn, J. K., 1964, Interférence entre la chorioméningite lymphocytaire et la leucémie de souris de Rauscher, C. R. Acad. Sci. Paris 259: 4191.

    CAS  Google Scholar 

  • Barski, G., and Youn, J. K., 1971, Protection of mice against Gross leukemia by interfering action of nonleukemogenic C-type murine viruses inoculated into newborns, J. Natl. Cancer Inst. 47: 575.

    PubMed  CAS  Google Scholar 

  • Bart, R. S., and Kopf, A. W., 1969, Inhibition of the growth of murine malignant melanoma with synthetic double-stranded ribonucleic acid, Nature (London) 224: 372.

    CAS  Google Scholar 

  • Bart, R. S., Kopf, A. W., and Silagi, S., 1971, Inhibition of the growth of murine malignant melanoma by polyinosinic–polycytidylic acid, J. Invest. Dermatol. 56: 33.

    PubMed  CAS  Google Scholar 

  • Bart, R. S., Kopf, A. W., Vilcek, J. T., and Lam, S., 1973, Role of interferon in the and-melanoma effects of poly (I).poly (C) and Newcastle disease virus, Nature (London) New Biol. 245: 229.

    CAS  Google Scholar 

  • Bart, R. S., Lam, S., Cooper, J. S., and Kopf, A. W., 1975, Retention of anti-melanoma effect of polyinosinic–polycytidylic acid in neonatally thymectomized, irradiated, leukopenic mice, J. Invest. Dermatol. 65: 285.

    PubMed  CAS  Google Scholar 

  • Baserga, R., and Kisieleski, W. E., 1961, Cell proliferation in tumor-bearing mice, Arch. Pathol. 72: 142.

    PubMed  CAS  Google Scholar 

  • Bekesi, J. G., and Holland, J. F., 1973, Combined chemotherapy and immunotherapy of transplantable and spontaneous murine leukemia in DBA/2 and AKR mice, in: Investigation and Stimulation of Immunity in Cancer Patients (G. Mathé and R. Weiner, eds), Vol. 1, Editions du Centre National la Recherche Scientifique, Paris, and Springer-Verlag, Heidelberg.

    Google Scholar 

  • Bekesi, J. G., Roboz, J. P., Zimmerman, E., and Holland, J. F., 1976, Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon, Cancer Res. 36: 631.

    PubMed  CAS  Google Scholar 

  • Berman, L. D., 1970, Inhibition of oncogenicity of murine sarcoma virus (Harvey) in mice by interferon, Nature (London) 227: 1349.

    CAS  Google Scholar 

  • Billiau, A., Leyten, R., Vandeputte, M., and De Somer, P., 1971, Inhibition of development of mammary tumors in C3H mice by neonatal administration of polycarboxylate, Life Sci. 10: 643.

    CAS  Google Scholar 

  • Blomgren, H., Strander, H., and Cantell, K., 1974, Effect of human leukocyte interferon on the response of lymphocytes to mitogenic stimuli in vitro, Scand. J. Immunol. 3: 697.

    PubMed  CAS  Google Scholar 

  • BLOMGREN, H., CANTELL, K., JOHANSSON, B., LAGERGREN, C., RINGBORG, U., and STRANDER, H., 1976, Interferon therapy in Hodgkin’s disease—a case report, Acta Med. Scand. 199: 527.

    PubMed  CAS  Google Scholar 

  • BRAUN, W., and LEVY, H. B., 1972, Interferon preparations as modifiers of immune responses, Proc. Soc. Exp. Biol. Med. 141: 769.

    PubMed  CAS  Google Scholar 

  • BRESLOW, D. S., EDWARDS, E. I., and NEWBERG, N. R., 1973, Divinyl ether–maleic anhydride (pyran) copolymer: The effect of molecular weight on biological activity, Nature (London) New Biol. 246: 160.

    CAS  Google Scholar 

  • Brodeur, B. R., and Merigan, T. C., 1974, Suppressive effect of interferon on the humoral immune response to sheep red blood cells in mice, J. Immunol. 113: 1319.

    PubMed  CAS  Google Scholar 

  • Came, P. E., and Moore, D. H., 1971, Inhibition of spontaneous mammary carcinoma of mice by treatment with interferon and poly I: C, Proc. Soc. Exp. Biol. Med. 137: 304.

    PubMed  CAS  Google Scholar 

  • Came, P. E., and Moore, D. H., 1972, Effect of exogenous interferon treatment on mouse mammary tumors, J. Natl. Cancer Inst. 48: 1151.

    PubMed  CAS  Google Scholar 

  • Cantell, K., 1970, Preparation of human leukocyte interferon, in: Symposia Series on Immunobiological Standardization, Vol. 14, No. 6, Karger, Basel and New York.

    Google Scholar 

  • Cantell, K., 1975, Towards clinical use of interferon, Proc. Gen. Assembly Jpn. Med. Soc., Kyoto, 18: 614.

    Google Scholar 

  • Cantell, K., Strander, H., Hadhazy, G., and Nevanlinna, H. R., 1968, How much interferon can be prepared in human leukocyte suspensions?, in: The Interferons ( G. Rita, ed.), p. 223, Academic Press, New York and London.

    Google Scholar 

  • Cantell, K., Pyhala, L., and Strander, H., 1974, Circulating human interferon after intramuscular injection into animals and man, J. Gen. Virol. 22: 453.

    Google Scholar 

  • Ceglowski, W. S., and Friedman, H., 1968, Immunosuppression by leukemia viruses. I. Effect of Friend disease virus on cellular and humoral hemolysin responses of mice to a primary immunization with sheep erythrocytes, J. Immunol. 101: 594.

    PubMed  CAS  Google Scholar 

  • Cerottini, J. C., Brunner, K. T., Lindahl, P., and Gresser, I., 1973, Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells, Nature (London) New Biol. 242: 152.

    CAS  Google Scholar 

  • Chany, C., and Robbe-Maridor, F., 1969, Enhancing effect of the murine sarcoma virus (MSV) on the replication of the mouse hepatitis virus (MHV) in vitro, Proc. Soc. Exp. Biol. Med. 131: 30.

    PubMed  CAS  Google Scholar 

  • Chernyakhovskaya, I. Y., Slavina, E. G., Svet-Moldavsky, G. J., 1970, Antitumor effect of lymphoid cells activated by interferon, Nature (London) 228: 71.

    CAS  Google Scholar 

  • Chester, T. J., Paucker, K., and Merigan, T. C., 1973, Suppression of mouse antibody producing spleen cells by various interferon preparations, Nature (London) 246: 92.

    CAS  Google Scholar 

  • CHIRIGOS, M. A., and PEARSON, J. W., 1973, Cure of murine leukemia with drug and interferon treatment, J. Natl. Cancer Inst. 51: 1367.

    PubMed  CAS  Google Scholar 

  • Chirigos, M. A., Turner, W., Pearson, J., and Griffin, W., 1969, Effective antiviral therapy of two murine leukemias with an interferon-inducing synthetic carboxylate copolymer, Int. J. Cancer 4: 267.

    PubMed  CAS  Google Scholar 

  • Chouroulinkov, I., Guillon, J. C., Lasne, C., and Gentil, A., 1971, Images de division observées sur des marcrophages de la cavité péritonéale de souris en culture in vitro, C. R. Acad. Sci. Paris 272: 2013.

    CAS  Google Scholar 

  • Claes, P., Billiau, A., De Clercq, E., Desmyter, J., Schonne, E., Vanderhaeghe, H., and De Somer, P., 1970, Polyacetal carboxylic acids: A new group of antiviral polyanions, J. Virol. 5: 313.

    PubMed  CAS  Google Scholar 

  • Clark, I. A., Allison, A. C., and Cox, F. E., 1976, Protection of mice against Babesia and Plasmodium with B.C.G., Nature (London) 259: 309.

    CAS  Google Scholar 

  • Cohen, A. M., Ketcham, A. S., and Morton, D. L., 1972, Cellular immunity to a common human sarcoma antigen and its specific inhibition by sera from patients with growing sarcomas, Surgery 72: 560.

    PubMed  CAS  Google Scholar 

  • Coley, W. B., 1894, Treatment of inoperable malignant tumors with the toxines of erysipelas and the Bacillus prodigiosus, Trans. Amer. Surg. Assoc. 12: 183.

    Google Scholar 

  • Coraggio, F., Coto, V., Fantoni, V., Galeota, C. A., and Lavegas, E., 1965, Azione di un interferon, proveniente de culture in vitro di cellule embrionali di topo infettate col virus del polioma, su un tumore trapiantabile nel topo (ceppo C 57), Boll. Ist. Sieroter. Milan. 44: 64.

    PubMed  CAS  Google Scholar 

  • Cortes, E. P., Holland, J. F., Wang, J. J., and Sinks, L. F., 1972, Doxorubicin in disseminated osteosarcoma, J. Amer. Med. Assoc. 221: 1132.

    Google Scholar 

  • De Clercq, E., and De Somer, P., 1971, Role of interferon in the protective effect of the double-stranded polyribonucleotide against murine tumors induced by Moloney sarcoma virus, J. Natl. Cancer Inst. 47: 1345.

    PubMed  Google Scholar 

  • De Clercq, E., and De Somer, P., 1972, Effect of chlorite-oxidized oxyamylose on Moloney sarcoma virus-induced tumor formation in mice, Eur. J. Cancer 8: 535.

    PubMed  Google Scholar 

  • De Clercq, E., and Merigan, T. C., 1970, Induction of interferon by nonviral agents, Arch. Intern. Med. 126: 94.

    PubMed  Google Scholar 

  • De Clercq, E., and Merigan, T. C., 1971, Moloney sarcoma virus-induced tumors in mice: Inhibition or stimulation by (poly-I).(poly-C), Proc. Soc. Exp. Biol. Med. 137: 590.

    Google Scholar 

  • De Clercq, E., and Stewart, W. E., II, 1974, Regression of autochthonous Moloney sarcoma virus-induced tumors in mice treated with polyriboinosinic—polyribocytidylic acid, J. Natl. Cancer Inst. 52: 591.

    PubMed  Google Scholar 

  • De Maeyer, E., Mobraaten, L., and De Maeyer-Guignard, J., 1973, Prolongation par l’interféron de la survie des greffes de peau chez la souris, C. R. Acad. Sci. Paris 277: 2101.

    Google Scholar 

  • De Maeyer, E., De Maeyer-Guignard, J., and Vandeputte, M., 1975, Inhibition by interferon of delayed-type hypersensitivity in the mouse, Proc. Natl. Acad. Sci. U.S.A. 72: 1753.

    PubMed  Google Scholar 

  • De Maeyer-Guignard, J., Cachard, A., and De Maeyer, E., 1975, Delayed-type hypersensitivity to sheep red blood cells: Inhibition of sensitization by interferon, Science 190: 574.

    PubMed  Google Scholar 

  • Desmyter, J., Rawls, W. E., and Melnick, J. L., 1968, A human interferon that crosses the species line, Proc. Natl. Acad.Sci. U.S.A. 59: 69.

    PubMed  CAS  Google Scholar 

  • Devita, V., Canellos, G., Carbone, P., Baron, S., Levy, H., and Gralnick, H., 1970, Clinical trials with the interferon (InF) inducer polyinosinic—cytidilic acid (PIC), Amer. Assoc.Cancer Res. 11: 21.

    Google Scholar 

  • Djerassi, I., Rominger, C. J., Kim, J., Turchi, J., and Meyer, E., 1970, Methotrexate-citrovorum in patients with lung cancer, Proc. Amer. Soc. Cancer Res. 11: 21.

    Google Scholar 

  • Djerassi, I., Rominger, C. J., Kim, J. S., Turchi, J., Suvansri, U., and Hughes, D., 1972, Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer, Cancer 30: 22.

    PubMed  CAS  Google Scholar 

  • Elgjo, K., and Degré, M., 1973, Polyinosinic—polycytidylic acid in two-stage skin carcinogenesis. Effect on epidermal growth parameters and interferon induction in treated mice, J. Natl. Cancer Inst. 51: 171.

    CAS  Google Scholar 

  • Emödi, G., Rufli, T., Just, M., and Hernandez, R., 1975, Human interferon therapy for herpes zoster in adults, Scand. J. Infect. Dis. 7: 1.

    PubMed  Google Scholar 

  • Falcoff, E., Falcoff, R., Fournier, F., and Chany, C., 1966, Production en masse, purification partielle et caracterisation d’un interféron destiné à des essais thérapeutiques humains, Ann. Inst. Pasteur 11: 562.

    Google Scholar 

  • Fauve, R. M., Hevin, B., Jacob, H., Gaillard, J. A., and Jacob, F., 1974, Antiinflammatory effects of murine malignant cells, Proc. Natl. Acad. Sci. U.S.A. 71: 4052.

    PubMed  CAS  Google Scholar 

  • Ferris, P., Padnos, M., and Molomut, N., 1971, Tumor inhibition in mice by M-P virus-induced interferon, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 30: 241.

    Google Scholar 

  • Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., 1967, Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes, Proc. Natl. Acad. Sci. U.S.A. 58: 1004.

    PubMed  CAS  Google Scholar 

  • Finkel, M. P., Reilly, C. A., JR., and Biskis, B. O., 1975, Viral etiology of bone cancer, Front. Radiat. Ther. Oncol. 10: 28.

    Google Scholar 

  • Finter, N. B., 1970, Exogenous interferon in animals and its clinical implications, Arch. Intern. Med. 126: 147.

    PubMed  CAS  Google Scholar 

  • Fisher, J. C., Cooperband, S. R., and Mannick, J. A., 1972, The effect of polyinosinic–polycytidylic acid on the immune response of mice to antigenically distinct tumors, Cancer Res. 32: 889.

    PubMed  CAS  Google Scholar 

  • Folkman, J., Merler, E., Abernathy, C., and Williams, G., 1971, Isolation of a tumor factor responsible for angiogenesis, J. Exp. Med. 133: 275.

    PubMed  CAS  Google Scholar 

  • Fontaine-Brouty-Boyé, D., Gresser, I., Macieira-Coelho, A., Rosenfeld, C., and Thomas, M. T., 1969, Cancérologie—Inhibition in vitro de la multiplication des cellules leucémiques murines L1210 par des préparations d’interféron, C. R. Acad. Sci. Paris 269: 406.

    Google Scholar 

  • Frayssinet, C., Gresser, I., Tovey, M., and Lindahl, P., 1973, Inhibitory effect of potent interferon preparations on the regeneration of mouse liver after partial hepatectomy, Nature (London) 245: 146.

    CAS  Google Scholar 

  • Fredrickson, T., Tambourin, P., Wendlin, F., Jasmin, C., and Smajda, F., 1975, Target cell of the polycythemia-inducing Friend virus: Studies with myleran, J. Natl. Cancer Inst. 55: 443.

    CAS  Google Scholar 

  • Frei, E., III, Schabel, F. M., and Goldin, A., 1974, Comparative chemotherapy of AKR lymphoma and human hematological neoplasia, Cancer Res. 34: 184.

    PubMed  CAS  Google Scholar 

  • Frei, E., III, Jaffe, N., Tattersall, M. H. N., Pitman, S., and Parker, L., 1975, New approaches to cancer chemotherapy with methotrexate, N. Engl. J. Med. 292: 846.

    PubMed  Google Scholar 

  • Friedman, R. M., 1966, Effect of interferon treatment on interferon production, J. Immunol. 96: 872.

    PubMed  CAS  Google Scholar 

  • Frost, P., and Lance, E. M., 1973, Abrogation of lymphocyte trapping by ascitic tumours, Nature (London) 246: 101.

    CAS  Google Scholar 

  • Gaffney, E. V., Picciano; P. T., and Grant, C. A., 1973, Inhibition of growth and transformation of human cells by interferon, J. Natl. Cancer Inst. 50: 871.

    PubMed  CAS  Google Scholar 

  • Gazdar, A. F., and Ikawa, Y., 1972, Synthetic RNA and DNA polynucleotides: In vivo and in vitro enhancement of oncogenesis by a murine sarcoma virus, Proc. Soc. Exp. Biol. Med. 140: 1166.

    PubMed  CAS  Google Scholar 

  • Gazdar, A. F., Steinberg, A. D., Spahn, G. F., and Baron, S., 1972, Interferon inducers: Enhance- ment of viral oncogenesis in mice and rats, Proc. Soc. Exp. Biol. Med. 139: 1132.

    PubMed  CAS  Google Scholar 

  • Gelboin, H. V., and Levy, H. B., 1970, Polyinosinic–polycytidylic acid inhibits chemically induced tumorigenesis in mouse skin, Science 167: 205.

    PubMed  CAS  Google Scholar 

  • Gericke, D., Kornhuber, B. C. G., and Chandra, P., 1973, Immunosuppressive activity of a heat-stable factor associated with interferon, Naturwissenschaften 10: 482.

    Google Scholar 

  • Gisler, R. H., Lindahl, P., and Gresser, I., 1974, Effects of interferon on antibody synthesis in vitro, J. Immunol. 113: 438.

    PubMed  CAS  Google Scholar 

  • Glasgow, L. A., and Friedman, S. B., 1969, Interferon and host resistance to Rauscher virus-induced leukemia, J. Virol. 3: 99.

    PubMed  CAS  Google Scholar 

  • Glaz, E. T., 1972, Study on the effect of statolon on methylcholanthrene oncogenesis in mice, Tumori 58: 185.

    PubMed  CAS  Google Scholar 

  • Graff, S., Kassel, R., and Kastner, 0., 1970, Interferon, Trans. N. Y. Acad. Sci. 32: 545.

    PubMed  CAS  Google Scholar 

  • Gresser, I., 1961, Production of interferon by suspensions of human leukocytes, Proc. Soc. Exp. Biol. Med. 108: 799.

    PubMed  CAS  Google Scholar 

  • Gresser, I., 1971, Clinical use of exogenous interferon, in: Viruses Affecting Man and Animals ( M. Saunders and M. Schaeffer, eds), p. 416, W. H. Green, St. Louis, Missouri.

    Google Scholar 

  • Gresser, I., 1972, Anti-tumor effects of interferon, in: Advances in Cancer Research, Vol. XVI ( G. Klein and S. Weinhouse, eds), p. 97, Academic Press, New York.

    Google Scholar 

  • Gresser, I., 1975, Interferon therapy: Obvious and not so obvious applications, Acta Med. Scand. 197: 49.

    Google Scholar 

  • Gresser, I., and Bourali, C., 1969, Exogenous interferon and inducers of interferon in the treatment of Balb/c mice inoculated with RC19 tumor cells, Nature (London) 223: 844.

    CAS  Google Scholar 

  • Gresser, I., and Bourali, C., 1970a, Antitumor effects of interferon preparations in mice, J. Natl. Cancer Inst. 45: 365.

    PubMed  CAS  Google Scholar 

  • Gresser, I., and Bourali, C., 1970b, Development of newborn mice during prolonged treatment with interferon, Eur. J. Cancer 6: 553.

    PubMed  CAS  Google Scholar 

  • Gresser, I., and Bourali, C., 1972, Inhibition by interferon preparations of a solid malignant tumour and pulmonary metastases in mice, Nature (London) New Biol. 236: 78.

    CAS  Google Scholar 

  • Gresser, I., and Bourali-Maury, C., 1973, The antitumor effect of interferon in lymphocyte and macrophage-depressed mice, Proc. Soc. Exp. Biol. Med. 144: 896.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Coppey, J., Falcoff, E., and Fontaine, D., 1966, Action inhibitrice de l’interféron brut sur le développment de la leucémie de Friend chez la souris, C. R. Acad. Sci. Paris 263: 586.

    CAS  Google Scholar 

  • Gresser, I., Coppey, J., Falcoff, E., and Fontaine, D., 1967a, Interferon and murine leukemia. I. Inhibitory effect of interferon preparations on development of Friend leukemia in mice, Proc. Soc. Exp. Biol. Med. 124: 84.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Fontaine, D., Coppey, J., Falcoff, R., and Falcoff, E., 1967b, Interferon and murine leukemia. II. Factors related to the inhibitory effect of interferon preparations on development of Friend leukemia in mice, Proc. Soc. Exp. Biol. Med. 124: 91.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Coppey, J., Fontaine-Brouty-Boyé, D., Falcoff, R. and Falcoff, E., 1967c, Interferon and murine leukaemia. III. Efficacy of interferon preparations administered after inoculation of Friend virus, Nature (London) 215: 174.

    CAS  Google Scholar 

  • Gresser, I., Coppey, J., Fontaine-Brouty-Boyé, D., Falcoff, E., Falcoff, R., Zajdela, F., Bourali, C., and Thomas, M. T., 1967d, The effect of interferon preparations on Friend leukaemia in mice, in: Ciba Found. Symp. Interferon (G. E. W. Wolstenholme and M. O’Conner, eds. ), p. 240.

    Google Scholar 

  • Gresser, I., Falcoff, R., Fontaine-Brouty-Boyé, D., Zajdela, F., Coppey, J., and Falcoff, E., 1967e, Interferon and murine leukemia. IV. Further studies on the efficacy of interferon preparations administered after inoculation of Friend virus, Proc. Soc. Exp. Biol. Med. 126: 791.

    CAS  Google Scholar 

  • Gresser, I., Berman, L., De Thé, G., Brouty-Boyé, D., Coppey, J., and Falcoff, E., 1968a, Interferon and murine leukemia. V. Effect of interferon preparations on the evolution of Rauscher disease in mice, J. Natl. Cancer Inst. 41: 505.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Coppey, J., and Bourali, C., 19686, Action inhibitrice de l’interféron brut sur la leucémie lymphoïde des souris AKR, C. R. Acad. Sci. Paris 267: 1900.

    Google Scholar 

  • Gresser, I., Coppey, J., and Bourali, C., 1969a, Interferon and murine leukemia. VI. Effect of interferon preparations on the lymphoid leukemia of AKR mice, J. Natl. Cancer Inst. 43: 1083.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Bourali, C., Levy, J. P., Fontaine-Brouty-Boyé, D., and Thomas, M. T., 1969b, Cancérologie—Prolongation de la survie des souris inoculées avec des cellules tumorales et traitées avec des préparations d’interféron, C. R. Acad. Sci. Paris 268: 994.

    CAS  Google Scholar 

  • Gresser, I., Bourali, C., Levy, J. P., Fontaine-Brouty-Boyé, D., and Thomas, M. T., 1969c, Increased survival in mice inoculated with tumor cells and treated with interferon preparations, Proc. Natl. Acad. Sci. U.S.A. 63: 51.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Fontaine-Brouty-Boyé, D., Bourali, C., and Thomas, M. T., 1969d, A comparison of the efficacy of endogenous, exogenous and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus, Proc. Soc. Exp. Biol. Med. 130: 236.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Bourali, C., Chouroulinkov, I., Fontaine-Brouty-Boyé, D., and Thomas, M. T., 1970a, Treatment of neoplasia in mice with interferon preparations, Ann. N. Y. Acad. Sci. 173: 694.

    CAS  Google Scholar 

  • Gresser, I., Brouty-Boyé, D., Thomas, M. T., and Macieira-Coelho, A., 1970b, Interferon and cell division. I. Inhibition of the multiplication of mouse leukemia L1210 cells in vitro by interferon preparations, Proc. Natl. Acad. Sci. U.S.A. 66: 1052.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Brouty-Boyé, D., Thomas, M. T., and Macieira-Coelho, A., 1970c, Interferon and cell division. II. Influence of various experimental conditions on the inhibition of L1210 cell multiplication in vitro by interferon preparations, J. Natl. Cancer Inst. 45: 1145.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Thomas, M. T., Brouty-Boyé, D., and Macieira-Coelho, A., 197la, Interferon and cell division. V. Titration of the anticellular action of interferon preparations, Proc. Soc. Exp. Biol. Med. 137: 1258.

    Google Scholar 

  • Gresser, I., Thomas, M. T., and Brouty-Boyé, D., 197 lb, Effect of interferon treatment of L1210 cells in vitro on tumor and colony formation, Nature (London) 231: 20.

    Google Scholar 

  • Gresser, I., Maury, C., and Brouty-Boyé, D., 1972, On the mechanism of the antitumor effect of interferon in mice, Nature (London) 239: 167.

    CAS  Google Scholar 

  • Gresser, I., Bandu, M. T., Tovey, M., Bodo, G., Paucker, K., and Stewart, W., II, 1973, Interferon and cell division. VII. Inhibitory effect of highly purified interferon preparations on the multiplication of leukemia L1210 cells, Proc. Soc. Exp. Biol. Med. 142: 7.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Bandu, M. T., and Brouty-Boyé, D., 1974a, Interferon and cell division. IX. Interferon-resistant L1210 cells: Characteristics and origin, J. Natl. Cancer Inst. 52: 553.

    PubMed  CAS  Google Scholar 

  • Gresser, I., Bandu, M. T., Broutv-Boyé, D., and Tovey, M., 19746, Pronounced antiviral activity of human interferon on bovine and porcine cells, Nature (London) 251: 543.

    Google Scholar 

  • Gresser, I., Tovey, M. G., Maury, C., and Chouroulonkov, I., 1975a, Lethality of interferon preparations for new-born mice, Nature (London) 258: 76.

    CAS  Google Scholar 

  • Gresser, I., Vignaux, F., Maury, C., and Lindahl, P., 19756, Factor(s) from Ehrlich ascites cell responsible for delayed rejection of skin allografts in mice and its assay on lymphocytes in vitro, Proc. Soc. Exp. Biol. Med.149:83.

    Google Scholar 

  • Gresser, I., Maury, C., and Tovey, M., 1976, Interferon and murine leukemia. VII. Therapeutic effect of interferon preparations after diagnosis of lymphoma in AKR mice, Int. J. Cancer 17: 647.

    PubMed  CAS  Google Scholar 

  • Grohsman, J., and Nowotny, A., 1972, The immune recognition of TA3 tumors, its facilitation by endotoxin and abrogation by ascites fluid, J. Immunol. 109: 1090.

    PubMed  CAS  Google Scholar 

  • Habif, D. V., Lipton, R., and Cantell, K., 1975, Interferon crosses the blood-cerebrospinal fluid barrier in monkeys, Proc. Soc. Exp. Biol. Med. 149: 287.

    PubMed  CAS  Google Scholar 

  • Havell, E. A., and Vilcek, J., 1972, Production of high-titered interferon in cultures of human diploid cells, Antimicrob. Agents Chemother. 2: 476.

    PubMed  CAS  Google Scholar 

  • Herling, I. M., 1975, Decrease in experimental liver metastasis in mice after treatment with pyran copolymer, J. Med. 6: 33.

    PubMed  CAS  Google Scholar 

  • Hilfenhaus, J., and Karges, H. E., 1974, Growth inhibition of human lymphoblastoid cells by interferon preparations, obtained from human leukocytes, Z. Naturforsch. 29c: 618.

    CAS  Google Scholar 

  • Hilleman, M. R., 1963, Interferon in prospect and perspective, J. Cell. Comp. Physiol. 62: 337.

    CAS  Google Scholar 

  • Hilleman, M. R., 1965, Immunologic, chemotherapeutic and interferon approaches to control of viral disease, Amer. J. Med. 38: 751.

    CAS  Google Scholar 

  • Hilleman, M. R., 1968, Approaches to prevention of leukemia in man, in: Perspectives in Leukemia, p. 272, Grune and Stratton, New York.

    Google Scholar 

  • Hilleman, M. R., 1969, Toward control of viral infections of man, Science 164: 506.

    PubMed  CAS  Google Scholar 

  • Hilleman, M. R., 1970a, Prospects for the use of double-stranded ribonucleic acid (poly I:C) inducers in man, J. Infect. Dis. 121: 196.

    PubMed  CAS  Google Scholar 

  • Hilleman, M. R., 1970b, Double-stranded RNAs (poly I:C) in the prevention of viral infections, Arch. Intern. Med. 126: 109.

    PubMed  CAS  Google Scholar 

  • Hirsch, M. S., Black, P. H., Tracy, G. S., Leibowitz, S., and SCHWARTZ, R. S., 1970a, Leukemia virus activation in chronic allogeneic disease, Proc. Natl. Acad. Sci. U.S.A. 67: 1914.

    PubMed  CAS  Google Scholar 

  • Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., 1970b, Immunosuppression, interferon inducers, and leukemia in mice, Proc. Soc. Exp. Biol. Med. 134: 309.

    PubMed  CAS  Google Scholar 

  • Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., 1972, Effects pf pyran copolymer on oncogenic virus infections in immunosuppressed hosts, J. Immunol. 108: 1312.

    PubMed  CAS  Google Scholar 

  • Hirsch, M. S., Ellis, D. A., Proffitt, M. R., Black, P. H., and Chirigos, M. A., 1973a, Effects of interferon on leukaemia virus activation in graft versus host disease, Nature (London)New Biol. 244: 102.

    CAS  Google Scholar 

  • Hirsch, M. S., Ellis, D A., Black, P. H., Monaco, A. P., and Wood, M. L., 19736, Leukemia virus activation during homograft rejection, Science 180: 500.

    Google Scholar 

  • Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., 1973c, Effects of pyran copolymer on leukemogenesis in immunosuppressed AKR mice, J. Immunol. 111: 91.

    PubMed  CAS  Google Scholar 

  • Hirsch, M. S., Ellis, D. A., Black, P. H., Monaco, A. P., and Wood, M. L., 1974, Immunosuppressive effects of an interferon preparation in vivo, Transplantation 17: 234.

    CAS  Google Scholar 

  • Hirsch, M. S., Black, P. H., and Proffitt, M. R., 1976, Interferon effects on immunologically activated murine leukemia viruses, Monogr. Natl. Cancer Inst. in press.

    Google Scholar 

  • Ho, M., and Postic, B., 1967a, Renal excretion of interferon, Nature (London) 214: 1230.

    CAS  Google Scholar 

  • Ho, M., and Postic, B., 19676, Prospects for applying interferon to man, in: Vaccines Against Viral and Rickettsia) Diseases of Man, Int. Conf. Pan Amer. Health Organ. Sci. Publ.147:632.

    Google Scholar 

  • Hrsak, I., and Marotti, T., 1973, Immunosuppression mediated by Ehrlich ascites fluid, Eur. J. Cancer 9: 717.

    PubMed  CAS  Google Scholar 

  • Huang, K. H., and Landay, M. E., 1969, Enhancement of the lethal effects of endotoxins by interferon inducers, J. Bacteriol. 100: 1110.

    PubMed  CAS  Google Scholar 

  • Huang, K. Y., Donahoe, R. M., Gordon, F. B., and Dressler, H. R., 1971, Enhancement of phagocytosis by interferon-containing preparations, Infect. Immun. 4: 581.

    PubMed  CAS  Google Scholar 

  • Huet, C., GrESSER, I., Bandu, M. T., and Lindahl, P., 1974, Increased binding of concanavalin A to interferon-treated murine leukemia L1210 cells, Proc. Soc. Exp. Biol. Med. 147: 52.

    PubMed  CAS  Google Scholar 

  • Hugh, R., Huang, K. Y., and Elliott, T. B., 1971, Enhancement of bacterial infections in mice by Newcastle disease virus, Infect. Immun. 3: 488.

    PubMed  CAS  Google Scholar 

  • Imanishi, J., Yokota, Y., Kishida, T., Mukainaka, T., and Matsuo, A., 1975, Phagocytosisenhancing effect of human leukocyte interferon preparation of human peripheral monocytes in vitro, Acta Virol. 19: 52.

    CAS  Google Scholar 

  • Isaacs, A., 1963, Interferon, in: Advances in Virus Research, Vol. X, p. 1, Academic Press, New York.

    Google Scholar 

  • Isaacs, A., and Lindemann, J., 1957, Virus interference, I. The interferon, Proc. R. Soc. London Ser. B. 147: 258.

    CAS  Google Scholar 

  • Jaffe, N., Frei, E., III, Traggis, D., and Bishop, Y., 1974, Adjuvant methotrexate and citrovorumfactor treatment of osteogenic sarcoma, N. Engl. J. Med. 291: 994.

    PubMed  CAS  Google Scholar 

  • Jasmin, C., Smadja-Joffe, F., Klein, B., and Kerdiles-Lebousse, C., 1976, Physiopathology of human and virus-induced murine leukemias, Cancer Res. 36: 603.

    PubMed  CAS  Google Scholar 

  • Johnson, H. M., Smith, B. G., and Baron, S., 1975, Inhibition of the primary in vitro antibody response by interferon preparations, J. Immunol. 114: 403.

    PubMed  CAS  Google Scholar 

  • Jordan, G. W., Fried, R. P., and Merigan, T. C., 1974, Administration of human leukocyte interferon in Herpes zoster. I. Safety, circulating antiviral activity, and host responses to infection, J. Infect. Dis. 130: 56.

    PubMed  CAS  Google Scholar 

  • Junglebut, C. W., and Kodza, H., 1962, Interference between lymphocytic choriomeningitis virus and the leukemia-transmitting agent of leukemia L2C in guinea pigs, Arch. Ges. Virusforsch. 12: 552.

    Google Scholar 

  • Kaplan, A. M., Morahan, P. S., and Regelson, W., 1974, Induction of macrophage-mediated tumor-cell cytotoxicity by pyran copolymer, J. Natl. Cancer Inst. 52: 1919.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. M., Walker, P. L., and Morahan, P. S., 1976, Tumor cell cytotoxicity versus cytotasis of pyran activated macrophages, Monogr. Natl. Cancer Inst. in press.

    Google Scholar 

  • Kassel, R. L., 1970, Carcinolytic effects of interferon, Clin. Obstet. Gynecol. 13: 910.

    PubMed  CAS  Google Scholar 

  • Kassel, R. L., Pascal, R. R., and Vas, A., 1972, Interferon-mediated oncolysis in spontaneous murine leukemia, J. Natl. Cancer Inst. 48: 1155.

    PubMed  CAS  Google Scholar 

  • Kassel, R. L., Old, L. J., Carswell, E. A., Fiore, N. C., and Hardy, W. D., JR., 1973, Serum-mediated leukemia cell destruction in AKR mice, J. Exp. Med. 138: 925.

    PubMed  CAS  Google Scholar 

  • Kende, M., and Glynn, J. P., 1971, Modifications of the response of autochthonous Moloney sarcoma virus-induced tumors to poly-I.C. by DEAE-dx, Chemotherapy 16: 281.

    PubMed  CAS  Google Scholar 

  • Kishida, T., Kato, S., and Nagano, Y., 1965, Effet du facteur inhibiteur du virus sur le fibrome de Shope, C. R. Soc. Biol. 159: 782.

    CAS  Google Scholar 

  • Kishida, T., Toda, S., Toida, A., and Hattori, T., 1971, Effet de l’interféron sur la cellule maligne de la souris, C. R. Soc. Biol. 169: 1498.

    Google Scholar 

  • Kleinschmidt, W. J., Ellis, L. F., Van Frank, R. M., and Murphy, E. B., 1968, Interferon stimulation by a double-stranded RNA of a mycophage in statolon preparations, Nature (London) 220: 167.

    CAS  Google Scholar 

  • KNIGHT, E., 1973, Interferon: Effect on the saturation density to which mouse cells will grow in vitro, J. Cell. Biol. 56: 846.

    CAS  Google Scholar 

  • Kravchenko, A. T., Voronin, E. S., and Kosmiadi, G. A., 1967, Effects of anti-rabies vaccine and fixed rabies virus on the development of tumours caused by Rous sarcoma, Acta Virol. 11: 145.

    CAS  Google Scholar 

  • Kreibich, G., Süss, R., Kinzel, V., and Hecker, E., 1970, On the biochemical mechanism of tumorigenesis in mouse skin. III. Decrease in tumor yields by poly I/C administered during initiation of skin by an intragastric dose of 7,12 dimethylbenz[a]anthracene, Z. Krebsforsch. 74: 383.

    PubMed  CAS  Google Scholar 

  • Kreider, J. W., 1970, Prevention of polyinosinic-polycytidylic acid inhibition of tumor growth by immunosuppression, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 29: 621 (abstract).

    Google Scholar 

  • Kreider, J. W., and Benjamin, S. A., 1972, Tumor immunity and the mechanism of polyinosinicpolycytidylic acid inhibition of tumor growth, J. Natl. Cancer Inst. 49: 1303.

    PubMed  CAS  Google Scholar 

  • Krulwich, T. A., Jacobs, C. F., Weisman, J. H., and Southam, C. M., 1962, Studies of six new viruses in tumor-bearing mice, Cancer Res. 22: 322.

    PubMed  CAS  Google Scholar 

  • Lacour, F., Spira, A., Lacour, J., and Prade, M., 1972, Polyadenylic-polyuridylic acid, an adjunct to surgery in the treatment of spontaneous mammary tumors in C3H/He mice and transplantable melanoma in the hamster, Cancer Res. 32: 648.

    PubMed  CAS  Google Scholar 

  • Lacour, F., Delage, G., and Chianale, C., 1975, Reduced incidence of spontaneous mammary tumors in C3H/He mice after treatment with polyadenylate–polyuridylate, Science 187: 256.

    PubMed  CAS  Google Scholar 

  • Lampson, G. P., Tytell, A. A., Nemes, M. M., and Hilleman, M. R., 1963, Purification and characterization of chick embryo interferon, Proc. Soc. Exp. Biol. Med. 112: 468.

    PubMed  CAS  Google Scholar 

  • Lampson, G. P., Tytell, A. A., Field, A. K., Nemes, M. M., and Hilleman, M. R., 1967, Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funicolosum, Proc. Natl. Acad. Sci. U.S.A. 58: 782.

    CAS  Google Scholar 

  • Larson, V. M., Clark, W. R., and Hilleman, M. R., 1969a, Influence of synthetic (poly-I.C.) and viral double-stranded ribonucleic acids on adenovirus 12 oncogenesis in hamsters, Proc. Soc. Exp. Biol. Med. 131: 1002.

    PubMed  CAS  Google Scholar 

  • Larson, V. M., Clark, W. R., Dagle, G. E., and Hilleman, M. R., 1969b, Influence of synthetic double-stranded ribonucleic acid, poly-I.C. on Friend leukemia in mice, Proc. Soc. Exp. Biol. Med. 132: 602.

    PubMed  CAS  Google Scholar 

  • Larson, V. M., Panteleakis, P. N., and Hilleman, M. R., 1970, Influence of synthetic double-stranded ribonucleic acid (poly-I.C.) on SV40 viral oncogenesis and transplant tumor in hamsters, Proc. Soc. Exp. Biol. Med. 133: 14.

    PubMed  CAS  Google Scholar 

  • Latarjet, R., 1964, Action inhibitrice d’extraits leucémiques isologues irradiés sur la leucémogénèse spontanée de la souris AKR, Ann. Inst. Pasteur 106: 1.

    Google Scholar 

  • Laufs, R., and Fleckenstein, B., 1973, Susceptibility to herpes virus saimiri and antibody development in Old and New World monkeys, Med. Microbiol. Immunol. 158: 227.

    PubMed  CAS  Google Scholar 

  • Laufs, R., and Meléndez, L. V., 1973, Oncogenicity of herpes virus ateles in monkeys, J. Natl. Cancer Inst. 51: 599.

    PubMed  CAS  Google Scholar 

  • Laufs, R., Steinke, H., Jacobs, C., Hilfenhaus, J., and Karges, H., 1974, Influence of interferon on the replication of onconogenic herpes virus in tissue cultures and in nonhuman primates, Med. Microbiol. Immunol. 160: 285.

    PubMed  CAS  Google Scholar 

  • Lee, E. S., and Mackenzie, D. H., 1964, Osteosarcoma—a study of the value of preoperative megavoltage radiotherapy, Br. J. Surg. 51: 252.

    PubMed  CAS  Google Scholar 

  • Lee, S. H. S., O’shaughnessy, M. V., and Rozee, K. R., 1972, Interferon induced growth depression in diploid and heteroploid human cells, Proc. Soc. Exp. Biol. Med. 139: 1438.

    PubMed  CAS  Google Scholar 

  • Leonard, B. J., Eccleston, E., and Jones, D., 1969, Toxicity of interferon inducers of the double-stranded RNA type, Nature (London) 224: 1023.

    CAS  Google Scholar 

  • Levy, H. B., Law, L. W., and RABSON, A. S., 1969, Inhibition of tumor growth by polyinosinicpolycytidylic acid, Proc. Natl. Acad. Sci. U.S.A. 62: 357.

    PubMed  CAS  Google Scholar 

  • Levy, H. B., Asofsky, R., Riley, F., Garapin, A., Cantor, H., and Adamson, R., 1970, The mechanism of the antitumor action of Poly I:Poly C, Ann. N. Y. Acad. Sci. 173: 640.

    CAS  Google Scholar 

  • Levy, H. B., Adamson, R., Carbone, P., Devita, V., Gazdar, A., Rhim, J., Weinstein, A., and Riley, F., 1971, Studies on the antitumor action of poly I.Poly C, in: Biological Effects of Polynucleotides ( R. F. Beers, Jr., and W. Braun, eds.), p. 55, Springer-Verlag, New York—Heidelberg—Berlin.

    Google Scholar 

  • Levy, H. B., Baer, G., Baron, S., Buckler, C. E., Gibbs, C. J., Iadarola, M. J., London, W. T., and RICE, J., 1975, A modified polyriboinosinic–polyribocytidylic acid complex that induces interferon in primates, J. Infect. Dis. 132: 434.

    PubMed  CAS  Google Scholar 

  • Levy, M. H., and Wheelock, E. F., 1975, Impaired macrophage function in Friend virus leukemia: Restoration by statolon, J. Immunol. 114: 962.

    PubMed  CAS  Google Scholar 

  • Levy-Koenig, R. E., Golgher, R. R., and Paucker, K., 1970, Immunology of interferons. II. Heterospecific activities of human interferons and their neutralization by antibody, J. Immunol. 104: 791.

    PubMed  CAS  Google Scholar 

  • Lieberman, M., Merigan, T. C., and Kaplan, H. S., 1971, Inhibition of radiogenic lymphoma development in mice by interferon, Proc. Soc. Exp. Biol. Med. 138: 575.

    PubMed  CAS  Google Scholar 

  • Lindahl, P., Leary, P., and Gresser, I., 1972, Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes, Proc. Natl. Acad. Sci. U.S.A. 69: 721.

    PubMed  CAS  Google Scholar 

  • Lindahl, P., Leary, P., and Gresser, I., 1973, Enhancement by interferon of the expression of surface antigens on murine leukemia L1210 cells, Proc. Natl. Acad. Sci. U.S.A. 70: 2785.

    PubMed  CAS  Google Scholar 

  • Lindahl, P., Leary, P., and Gresser. I., 1974, Enhancement of the expression of histocompatibility antigens of mouse lymphoid cells by interferon in vitro, Eur. J. Immunol. 4: 779.

    CAS  Google Scholar 

  • Lindahl, P., Gresser, I., Leary, P., and Tovey, M., 1976, Interferon treatment of mice: Enhanced expression of histocompatibility antigens on lymphoid cells, Proc. Natl. Acad. Sci. U.S.A. 73: 1284.

    PubMed  CAS  Google Scholar 

  • Lindahl-Magnusson, P., Leary, P., and Gresser, I., 1971, Interferon and cell division, VI. Inhibitory effect of interferon on the multiplication of mouse embryo and mouse kidney cells in primary cultures, Proc. Soc. Exp. Biol. Med. 138: 1044.

    PubMed  CAS  Google Scholar 

  • Lindahl-Magnusson, P., Leary, P., and Gresser, I., 1972, Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells, Nature (London) New Biol. 273: 120.

    Google Scholar 

  • Lockart, R. Z., JR., 1967, Recent progress in research on interferons, Prog. Med. Virol. 9: 451.

    PubMed  Google Scholar 

  • Lyon, G. M., JR., 1970, Growth stimulation of tissue culture cells derived from patients with neuroblastoma, Cancer Res. 30: 2521.

    PubMed  CAS  Google Scholar 

  • MATHÉ, G., 1971, Active immunotherapy, Adv. Cancer Res. 14: 1.

    PubMed  Google Scholar 

  • Mathé, G., Amiel, J. L., Schwarzenberg, L., Schneider, M., Hayat, M., De Vassal, F., Jasmin, C., Rosenfeld, C., Sakouhi, M., and Choay, J., 1970, Remission induction with poly IC in patients with acute lymphoblastic leukaemia (preliminary results), Eur. J. Clin. Biol. Res. 15: 671.

    Google Scholar 

  • Mayo, J. G., 1972, Biologic characterization of the subcutaneously implanted Lewis lung tumor, Cancer Chemother. Rep. 3: 325.

    CAS  Google Scholar 

  • Mcneill, T. A., and Fleming, W. A., 1971, The relationship between serum interferon and an inhibitor of mouse haemopoietic colonies in vitro, Immunology 21: 761.

    CAS  Google Scholar 

  • Mcneill, T. A., and Gresser, I., 1973, Inhibition of haemopoietic colony growth by interferon preparations from different sources, Nature (London) New Biol. 244: 173.

    CAS  Google Scholar 

  • Meier, H., Myers, D. D., and Huebner, R. J., 1970a, Statolon-therapy of spontaneous viral-caused mouse tumors, Naturwissenchaften 57: 6.

    Google Scholar 

  • Meier, H., Myers, D. D., and Huebner, R. J., 1970b, Differential effect of a synthetic polyribonucleotide complex on spontaneous and transplanted leukemia in mice, Life Sci. 9: 653.

    CAS  Google Scholar 

  • Merigan, T. C., 1967, Interferon’s promise in clinical medicine, Amer. J. Med. 43: 817.

    PubMed  Google Scholar 

  • Merigan, T. C., Rand, K. H., Adballah, P. S., Jordan, G. W., Feldman, S., and Fried, R. P., 1976, Administration of human leukocyte interferon in varicella—zoster infections. II. Preliminary controlled trials to establish effective dosage in patients with malignancy, J. Infect. Dis. in press.

    Google Scholar 

  • Metcalf, D., and Wiadrowski, M., 1966, Autoradiographic analysis of lymphocyte proliferation in the thymus and in the thymic lymphoma tissue, Cancer Res. 26: 483.

    PubMed  CAS  Google Scholar 

  • Mobraaten, L. E., De Maeyer, E., and De Maeyer-Guignard, J., 1973, Prolongation of allograft survival in mice by inducers of interferon, Transplantation 16: 415.

    PubMed  CAS  Google Scholar 

  • Mocarelli, P., Villa, M. L., Garotta, G., Porta, C., Bigi, G., and Clerici, E., 1973, Reversibility of the immunodepression due to Ehrlich ascites carcinoma, J. Immunol. 111: 973.

    PubMed  CAS  Google Scholar 

  • Molomut, N., and Padnos, M., 1965, Inhibition of transplantable and spontaneous murine tumours by the M-P virus, Nature (London) 208: 948.

    CAS  Google Scholar 

  • Morahan, P. S., and Kaplan, A. M., 1976, Macrophage activation and antitumor activity of biologic and synthetic agents, Int. J. Cancer 17: 82.

    PubMed  CAS  Google Scholar 

  • Morahan, P. S., Munson, J. A., Baird, L. G., Kaplan, A. M., and Regelson, W., 1974, Antitumor action of pyran copolymer and tilorone against Lewis lung carcinoma and B-16 melanoma, Cancer Res. 34: 506.

    PubMed  CAS  Google Scholar 

  • Morahan, P. S., Schuller, G. B., Snodgrass, M. J., and Kaplan, A. M., 1976, Paradoxical effects of immunopotentiators on tumors and tumor viruses, J. Infect. Dis. 133S: A249.

    PubMed  Google Scholar 

  • Morgan, W. W., and Cameron, I. L., 1973, Effect of fast-growing transplantable hepatoma on cell proliferation in host tissue of the mouse, Cancer Res. 33: 441.

    PubMed  CAS  Google Scholar 

  • Mundy, G. R., Raisz, L. G., Cooper, R. A., Schechter, G. P., and Salmon, S. E., 1974, Evidence for the secretion of an osteoclast stimulating factor in myeloma, N. Engl. J. Med. 291: 1041.

    PubMed  CAS  Google Scholar 

  • Nadel, E. M., and Haas, V. H., 1956, Effect of the virus of lymphocytic choriomeningitis on the course of leukemia in guinea pigs and mice, J. Natl. Cancer Inst. 17: 221.

    PubMed  Google Scholar 

  • Nebert, D. W., and Friedman, R. M., 1973, Stimulation of aryl hydrocarbon hydroxylase induction in cell cultures by interferon, J. Virol. 11: 193.

    PubMed  CAS  Google Scholar 

  • Nemes, M. M., Tytell, A. A., Lampson, G. P., Field, A. K., and Hilleman, M. R., 1969, Inducers of interferon and host resistance. VI. Antiviral efficacy of poly-I.C. in animal models, Proc. Soc. Exp. Biol. Med. 132: 776.

    PubMed  CAS  Google Scholar 

  • Nordlund, J. J., Wolff, S. M., and Levy, H. B., 1970, Inhibition of biologic activity of poly I:poly C by human plasma, Proc. Soc. Exp. Biol. Med. 133: 439.

    PubMed  CAS  Google Scholar 

  • Oker-Blom, N., and Leinikki, P., 1965, Effect of Coxsackie virus of group A and B on Rous sarcoma virus, Arch. Ges. Virusforsch. 17: 448.

    PubMed  CAS  Google Scholar 

  • Oker-Blom, N., and Strandström, H., 1956a, Effect of Coxsackie virus on the growth of the Rous sarcoma in embryonated chicken eggs, Ann. Med. Exp. Fenn. 34: 293.

    PubMed  CAS  Google Scholar 

  • Oker-Blom, N., and Strandström, H., 1956b, Effect of Coxsackie virus on the growth of the Rous sarcoma in chickens, Ann. Med. Exp. Fenn. 34: 301.

    PubMed  CAS  Google Scholar 

  • Old, L. J., Benacerraf, B., and Stockert, E., 1963, Increased resistance to Mengo virus following infection with bacillus Calmette-Guérin, Colloq. Int. C.N.R.S., No. 115, p. 319.

    Google Scholar 

  • O’shaughnessy, M. V., Lee, S. H. S., and Rozee, K. R., 1972, Interferon inhibition of DNA synthesis and cell division, Can. J. Microbiol. 18: 145.

    PubMed  Google Scholar 

  • Paucker, K., Cantell, K., and Henle, W., 1962, Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells, Virology 17: 324.

    PubMed  CAS  Google Scholar 

  • Pearson, J. W., Turner, W., Ebert, P. S., and Chirigos, M. A., 1969, Effectiveness of therapy with a multistranded synthetic polynucleotide complex against a murine sarcoma virus, App!. Microbiol. 18: 474.

    Google Scholar 

  • Pierce, M., Carter, R. E., and Rigor, E., 1959, Studies on the relationship of viral infections to leukemia in mice, Cancer 12: 222.

    PubMed  CAS  Google Scholar 

  • Pieroni, R. E., Broderick, E. J., Bundeally, A., and Levine, L., 1970, A simple method for the quantitâtion of submicrogram amounts of bacterial endotoxin, Proc. Soc. Exp. Biol. Med. 133: 790.

    PubMed  CAS  Google Scholar 

  • Pieroni, R. E., Bundeally, A. E., and Levine, L., 1971, The effect of actinomycin D on the lethality of poly I:C, J. Immunol. 106: 1128.

    PubMed  CAS  Google Scholar 

  • Pilch, D. J. F., and Planterose, D. N., 1971, Effects on Friend disease of double-stranded RNA of fungal origin, J. Gen. Virol. 10: 155.

    PubMed  CAS  Google Scholar 

  • Potmesil, M., and Goldfeder, A., 1972, Inhibitory effect of polyinosinic: polycytidylic acid on the growth of transplantable mouse mammary carcinoma, Proc. Soc. Exp. Biol. Med. 139: 1392.

    PubMed  CAS  Google Scholar 

  • Pudov, V. I., 1971, The influence of interferon on metastasization of Brown-Pearce carcinoma, Bull. Exp. Biol. Med. (USSR) 8: 91.

    Google Scholar 

  • Pyhalä, L., and Cantell, K., 1974, Clearance of human interferon in rabbits induced to make rabbit interferon, Proc. Soc. Exp. Biol. Med. 146: 394.

    PubMed  Google Scholar 

  • Rabin, H., Adamson, R. H., Neubauer, R. H., Cicmanec, J. L., and Wallen, W. C., 1976, Pilot studies with human interferon in herpes virus saimiri induced lymphoma in owl monkeys, Cancer Res. 36: 715.

    PubMed  CAS  Google Scholar 

  • Rana, M. W., Pinkerton, H., and Rankin, A., 1975, Effect of rifamycin and tilorone derivatives on Friend virus leukemia in mice, Proc. Soc. Exp. Biol. Med. 150: 32.

    PubMed  CAS  Google Scholar 

  • Regelson, W., 1967, Prevention and treatment of Friend leukemia virus (FLV) infection by interferon-inducing synthetic polyanions, in: The Reticuloendothelial System and Atherosclerosis ( N. R. DiLuzio and R. Paoletti, eds.), p. 315, Plenum Press, New York.

    Google Scholar 

  • Regelson, W., 1968, The antitumor activity of polyanions, in: Advances in Chemotherapy ( A. Goldin, F. Hawking, and R. J. Schnitzer, eds.), Vol. 3, p. 303, Academic Press, New York.

    Google Scholar 

  • Regelson, W., 1973, Host modulation of resistance to infection and neoplasia, Annu. Rep. Med. Chem. 8: 160.

    Google Scholar 

  • Regelson, W., and Foltyn, 0., 1966, Prevention and treatment of Friend leukemia virus (FLV) infection by polyanions and phytohemagglutinin, Proc. Amer. Assoc. Cancer Res. 7: 58.

    Google Scholar 

  • Regelson, W., Morahan, P., Kaplan, A. M., Baird, L. G., and Munson, J. A., 1973, Synthetic polyanions: Molecular weight, macrophage activation, and immunologic response, Excerpta Med. Int. Congr. Ser. No. 325, p. 97.

    Google Scholar 

  • Rev-Kury, L. H., Kury, G., and Firedell, G. H., 1966, Thymidine uptake in livers of tumor-bearing hamsters, Arch. Pathol. 82: 77.

    PubMed  CAS  Google Scholar 

  • Rheins, M. S., Barker, A. D., and Wilson, H. E., 1971, The amelioration of Friend virus leukemia by the sequential administration of a series of viral and nonviral interferon inducers, Bacteriol. Proc., p. 188.

    Google Scholar 

  • Rhim, J. S., and Huebner, R. J., 1969, Inhibitory effect of statolon on virus-induced sarcoma of mice, Antimicrob. Agents Chemother., p. 177.

    Google Scholar 

  • Rhim, J. S., and Huebner, R. J., 1971, Comparison of the antitumor effect of interferon and interferon inducers, Proc. Soc. Exp. Biol. Med. 136: 524.

    PubMed  CAS  Google Scholar 

  • Robinson, R. A., Devíta, V. T., Levy, H. B., Baron, S., Hubbard, S. P., and Levine, A. S., 1976, A Phase I-II trial of multiple-dose polyriboinosinic-polyribocytidylic acid (poly I-poly C) in patients with leukemia or solid tumors, in preparation.

    Google Scholar 

  • Rossi, G. B., Marchegiani, M., Matarese, G. P., and Gresser, I., 1975, Inhibitory effect of interferon on multiplication of Friend leukemia cells in vivo, J. Natl. Cancer Inst. 54: 993.

    CAS  Google Scholar 

  • Rowe, W. P., Pugh, W. E., and Hartley, J. W., 1970, Plaque assay techniques for murine leukemia viruses, Virology 42: 1136.

    PubMed  CAS  Google Scholar 

  • Rudali, G., and Jullien, P., 1966, Notes originales sur l’utilisation des leucémies spontanées des souris pour les recherches chimiothérapeutiques, Rev. Fr. Etud. Clin. Biol. 11: 183.

    PubMed  CAS  Google Scholar 

  • Salerno, R. A., Whitmire, C. E., Garcia. I. M., and Huebner, R. J., 1972, Chemical carcinogenesis in mice inhibited by interferon, Nature (London) New Biol. 239: 31.

    CAS  Google Scholar 

  • Sano, E., Matsui, Y., and Kobayashi, S., 1974, Production of mouse interferon with high titers in a large-scale suspension culture system, Jpn. J. Microbiol. 18: 165.

    CAS  Google Scholar 

  • Sarma, P. S., Shiu, G., Neubauer, R. H., Baron, S., and Huebner, R. J., 1969, Virus-induced sarcoma of mice: Inhibition by a synthetic polyribonucleotide complex, Proc. Natl. Acad. Sci. U.S.A. 62: 1046.

    PubMed  CAS  Google Scholar 

  • Sarma, P. S., Neubauer, R. H., and Rabstein, L., 1971, Murine sarcoma and leukemia viral infection of mice. Effect of long-term treatment with poly-I.C., Proc. Soc. Exp. Biol. Med. 137: 469.

    CAS  Google Scholar 

  • Schabel, F. M., JR., Skipper, H. E., Trader, M. W., Laster, W. R., JR., and Simpson-Herren, L., 1969, Spontaneous AK leukemia (lymphoma) as a model system, Cancer Chemother. Rep. 53: 329.

    PubMed  Google Scholar 

  • Schuller, G. B., Morahan, P. S., and Snodgrass, M., 1975, Inhibition and enhancement of Friend leukemia virus by pyran copolymer, Cancer Res. 35: 1915.

    PubMed  CAS  Google Scholar 

  • Shirodkar, M. V., 1965, The blocking effect of West Nile virus on production of sarcoma by Rous virus in chickens, J. Immunol. 95: 1121.

    PubMed  CAS  Google Scholar 

  • Skipper, H. E., Schabel, F. M., Jr., Trader, M. W., and Laster, W. R., JR., 1969, Response to therapy of spontaneous, first passage, and long passage lines of AK leukemia, Cancer Chemother. Rep. 53: 345.

    PubMed  CAS  Google Scholar 

  • Skipper, H. E., Schabel, F. M., Jr., Trader, M. W., Laster, W. R., Jr., Simpson-Herren, L., and LLOYD, H. H., 1972, Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model—end of 1971, Cancer Chemother. Rep. 56: 273.

    PubMed  CAS  Google Scholar 

  • Slamon, D. J., 1973, Protective effect of the double-stranded polyribonucleotide, polyinosinicpolycytidylic acid, against rat erythroblastosis induced by murine erythroblastosis virus, J. Natl. Cancer Inst. 51: 851.

    PubMed  CAS  Google Scholar 

  • Slavina, E. G., Leneva, N. V., and Svet-Moldavsky, G. J., 1974, Sensitivity of target cells to the cytotoxic effects of lymphocytes induced by interferon, Folia Biol. (Prague) 20: 231.

    CAS  Google Scholar 

  • Smadja-Joffe, F., Jasmin, C., Malaise, E. P., and Bournoutian, C., 1973, Study of the cellular proliferation kinetics of Friend leukemia, Int. J. Cancer 11: 300.

    PubMed  CAS  Google Scholar 

  • Smadja-Joffe, F., Jasmin, C., Kerdiles, C., and Klein, B., 1975, Friend leukemia: A model for the physiopathology of human chronic leukemia, Eur. J. Cancer 11: 831.

    PubMed  CAS  Google Scholar 

  • Smadja-Joffe, F., Klein, B., Kerdiles, C., Feinendegen, L., and Jasmin, C., 1976, Study of cell death in Friend leukemia, Cell Tissue Kinet. 9: 131.

    PubMed  CAS  Google Scholar 

  • Snodgrass, M. J., Morahan, P. S., and Kaplan, A. M., 1975, Histopathology of the host response to Lewis lung carcinoma: Modulation by pyran, J. Natl. Cancer Inst. 55: 455.

    PubMed  CAS  Google Scholar 

  • Southam, C. M., 1960, Present status of oncolytic virus studies, Trans. N. Y. Acad. Sci. 83: 551.

    Google Scholar 

  • Southam, C. M., and Epstein, J. D., 1953, The effect of Russian encephalitis and other viruses on mouse leukemia, Cancer Res. 13: 581.

    PubMed  CAS  Google Scholar 

  • Southam, C. M., and Moore, A. E., 1952, Clinical studies of viruses as antineoplastic agents with particular reference to Egypt 101 virus, Cancer 5: 1025.

    PubMed  CAS  Google Scholar 

  • Squartini, F., Olivi, M., Bolis, G. B., Ribacchi, R., and Giraldo, G., 1967, Reciprocal interference between mouse mammary tumour virus and leukaemia virus, Nature (London) 214: 730.

    CAS  Google Scholar 

  • Steeves, R. A., Mirand, E. A., Thomson, S., and Avila, L., 1969, Enhancement of spleen focus formation and virus replication in Friend virus-infected mice, Cancer Res. 29: 1111.

    PubMed  CAS  Google Scholar 

  • Stewart, W. E., II, Gosser, L. B., and Lockart, R. Z., JR., 1971, Priming: A nonantiviral function of interferon, J. Virol. 7: 792.

    PubMed  CAS  Google Scholar 

  • Stewart, W. E., II, Gresser, I., Tovey, M. G., Bandu, M-T., and Le Goff, S., 1976, Identification of the cell multiplication inhibitory factors in interferon preparations as interferons, Nature 262:300: ST.

    Google Scholar 

  • Geme, G. W., Jr., Horrigan, D. S., and Toyama, P. S., 1969, The effect of 6-mercaptopurine on the synthesis and action of interferon, Proc. Soc. Exp. Biol. Med. 130: 852.

    Google Scholar 

  • Stim, T. B., 1970, Interference of Cocal virus with Friend leukemia virus-induced splenomegaly in DBA/2J mice, Proc. Soc. Exp. Biol. Med. 134: 413.

    PubMed  CAS  Google Scholar 

  • Strander, H., 1971, Production of interferon by suspended human leukocytes, Thesis monograph, Karolinska Institutet, Stockholm, Sweden.

    Google Scholar 

  • Strander, H., and Cantell, K., 1966, Production of interferon by human leukocytes in vitro, Ann. Med. Exp. Fenn. 44: 265.

    CAS  Google Scholar 

  • Strander, H., and Cantell, K., 1967, Further studies on the production of interferon by human leukocytes in vitro, Ann. Med. Exp. Fen. 45: 20.

    CAS  Google Scholar 

  • Strander, H., and Cantell, K., 1974, Studies on antiviral and antitumor effects of human leukocyte interferon in vitro and in vivo, Proceedings of a Tissue Culture Association Workshop, Tissue Culture Association Monograph No. 3, Rockville, Maryland, p. 49.

    Google Scholar 

  • Strander, H., Cantell, K., Carlström, G., and Jacobsson, P. A., 1973a, Clinical and laboratory investigations on man: Systemic administration of potent interferon to man, J. Natl. Cancer Inst. 51: 733.

    PubMed  CAS  Google Scholar 

  • Strander, H., Jacobsson, P. A., Carlström, G., and Cantell, K., 1973b, Administration of potent interferon to patients with malignant diseases, Cancer Cytol. 13: 18.

    Google Scholar 

  • Strander, H., Mogensen, K. E., and Cantell, K., 1975, Production of human lymphoblastoid interferon, J. Clin. Microbiol. 1: 116.

    PubMed  CAS  Google Scholar 

  • Strander, H., Cantell, K., Ingimarsson, S., Jakobsson, P. A., Nilsonne, U., and Söderberg, G., 1976a, Interferon treatment of osteogenic sarcoma—a clinical trial, J. Natl. Cancer Inst. in press.

    Google Scholar 

  • Strander, H., Cantell, K., Carlström, G., Ingimarsson, S., Jakobsson, P. A., and Nilsonne, U., 1976b, Acute infections in interferon-treated osteosarcoma patients—preliminary report of a comparative study, J. Infect. Dis. in press.

    Google Scholar 

  • Strandstrom, H., Sandelin, K., and Oker-Blom, N., 1962, Inhibitory effect of Coxsackie virus, influenza virus, and interferon on Rous sarcoma virus, Virology 16: 384.

    PubMed  CAS  Google Scholar 

  • Strauss, M. J., Chol, S. C., and Goldin, A., 1973, Increased life-span in AKR leukemia mice treated with prophylactic chemotherapy, Cancer Res. 33: 1724.

    Google Scholar 

  • Subrahmanyan, T. P., and Mims, C. A., 1966, Fate of intravenously administered interferon and the distribution of interferon during virus infections in mice, Br. J. Exp. Pathol. 47: 168.

    PubMed  CAS  Google Scholar 

  • Suddith, R. L., Kelly, P. J., Hutchison, H. T., Murray, E. A., and Haber, B., 1975, In vitro demonstration of an endothelial proliferative factor produced by neural cell lines, Science 190: 682.

    CAS  Google Scholar 

  • Svec, J., Novotna, L., and Thurzo, V., 1972, Toward control of tumour and virus growth by helical RNA. I. Effect of poly I:C on tumour transplantation resistance in animals bearing tumours of viral and non-viral origin, Neoplasma 19: 447.

    PubMed  CAS  Google Scholar 

  • Svet-Moldavsky, G. J., and Chernyakhovskaya, I. Ju., 1967, Interferon and the interaction of allogeneic normal and immune lymphocytes with L-cells, Nature (London) 215: 1299.

    CAS  Google Scholar 

  • Svet-Moldavsky, G. J., Nemirovskaya, B. M., Osipova, T. V., Slavina, E. G., Zinzar, S. N., Karmonova, N. V., and Morozova, L. F., 1974, Interferonogenicity of antigens and “early” cytotoxicity of lymphocytes, Folia Biol. (Prague) 20: 225.

    CAS  Google Scholar 

  • Takeyama, H., Nishiwaki, H., Yamada, K., ITO, Y., and Nagata, I., 1975, Experimental studies on antitumor effects of interferon, personal communication in Interferon Scientific Memoranda, Memo I-A 164 /1.

    Google Scholar 

  • Toth, F. D., Vagzi, L., and Berencsi, C., 1971, Effect of interferon treatment on the tumour-specific antibody response of Balb/c mice infected with Rauscher virus, Acta Microbiol. Acad. Sci. Hung. 18: 109.

    PubMed  CAS  Google Scholar 

  • Tovey, M. G., Begon-Lours, J., and Gresser, I., 1974, A method for the large-scale production of potent interferon preparations, Proc. Soc. Exp. Biol. Med. 146: 809.

    PubMed  CAS  Google Scholar 

  • Tovey, M. G., Brouty-Boyé, D., and Gresser, I., 1975, Early effect of interferon on mouse leukemia cells cultivated in a chemostat, Proc. Natl. Acad. Sci. U.S.A. 72: 2265.

    PubMed  CAS  Google Scholar 

  • Toy, S. T., Weislow, O. S., and Wheelock, E. F., 1973, Suppression of established Friend virus leukemia by statolon. VII. Relative roles of interferon and the immune response in development of FV-dormant infections, Proc. Soc. Exp. Biol. Med. 143: 726.

    PubMed  CAS  Google Scholar 

  • Turner, J. C., and Mulliken, B., 1950, Effects of intravenous vaccinia in mice with sarcoma 180 or leukemia 9417, Cancer 3: 354.

    Google Scholar 

  • Turner, J. C., Mulliken, B., and Kritzler, R. A., 1948, Influence of vaccine virus on a transmissible leukemia of mice, Proc. Soc. Exp. Biol. Med. 69: 304.

    PubMed  CAS  Google Scholar 

  • Turner, W., Chirigos, M. A., and Scott, D., 1968, Enhancement of Friend and Rauscher leukemia virus replication in mice by Guaroa virus, Cancer Res. 28: 1064.

    PubMed  CAS  Google Scholar 

  • Turner, W., Chan, S. P., and Chirigos, M. A., 1970, Stimulation of humoral and cellular antibody formation in mice by poly I:C, Proc. Soc. Exp. Biol. Med. 133: 334.

    PubMed  CAS  Google Scholar 

  • Vandeputte, M., De Lafonteyne, J., Billiau, A., and De Somer, P., 1967, Influence and production of interferon in Rauscher virus infected mice, Arch. Ges. Virusforsch. 20: 235.

    Google Scholar 

  • Vandeputte, M., Datta, S. K., Billiau, A., and De Somer, P., 1970, Inhibition of polyoma-virus oncogenesis in rats by polyriboinosinic–ribocytidylic acid, Eur. J. Cancer 6: 323.

    PubMed  CAS  Google Scholar 

  • Wagner, R. R., 1965, Interferon: A review and analysis of recent observations, Amer. J. Med. 38: 726.

    CAS  Google Scholar 

  • Webb, D., Braun, W., and Plescia, O. J., 1972, Antitumor effects of polynucleotides and theophylline, Cancer Res. 32: 1814.

    PubMed  CAS  Google Scholar 

  • Weinstein, A. J., Gazdar, A. F., Sims, H. L., and Levy, H. B., 1971, Lack of correlation between interferon induction and antitumour effect of poly I–poly C, Nature (London) New Biol. 231: 53.

    Google Scholar 

  • Weislow, O. S., and Wheelock, E. F., 1975a, Depression of humoral immunity to sheep erythrocytes in vitro by Friend virus leukemic spleen cells: Induction of resistance by statolon, J. Immunol. 114: 211.

    PubMed  CAS  Google Scholar 

  • Weislow, O. S., and Wheelock, E. F., 1975b, Suppression of established Friend virus leukemia by statolon: Potentiation of statolon’s leukemosuppressive activity by chlorite-oxidized oxyamylose, Infect. Immun. 11: 129.

    PubMed  CAS  Google Scholar 

  • Weislow, O. S., Friedman, H., and Wheelock, E. F., 1973, Suppression of established Friend virus leukemia by statolon. V. Reversal of virus-induced immunodepression to sheep erythrocytes, Proc. Soc. Exp. Biol. Med. 142: 401.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., 1966, The effects of nontumor viruses on virus-induced leukemia in mice: Reciprocal interference between Sendai virus and Friend leukemia virus in DBA/2 mice, Proc. Natl. Acad. Sci. U.S.A. 55: 774.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., 1967a, Effect of statolon on Friend virus leukemia in mice, Proc. Soc. Exp. Biol. Med. 124: 855.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., 1967b, Inhibitory effects of Sendai virus on Friend virus leukemia in mice, J. Natl. Cancer Inst. 38: 771.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., 1971, Mechanism of suppression of established Friend virus leukemia by statolon, Bacteriol. Proc., p. 241.

    Google Scholar 

  • Wheelock, E. F., and Caroline, N. L., 1970, Suppression and emergence of established Friend virus leukemia: Clinical remission after statolon treatment, Ann. N. Y. Acad. Sci. 173: 582.

    CAS  Google Scholar 

  • Wheelock, E. F., and Dingle, J. H., 1964, Observations on the repeated administration of viruses to a patient with acute leukemia. A preliminary report, N. Engl. J. Med. 271: 645.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., and Larke, R. P., 1968, Efficacy of interferon in the treatment of mice with established Friend virus leukemia, Proc. Soc. Exp. Biol. Med. 127: 230.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., Caroline, N. L., and Moore, R. D., 1969, Suppression of established Friend virus leukemia by statolon, J. Virol. 4: 1.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., Caroline, N. L., and Moore, R. D., 1971, Suppression of established Friend virus leukemia by statolon. III. Development of FV-leukemogenic and FV-immunogenic activities in bloods, spleens, and lymph nodes, J. Natl. Cancer Inst. 46: 797.

    CAS  Google Scholar 

  • Wheelock, E. F., TOY, S. T., Caroline, N. L., Sibal, L. R., Fink, M. A., Beverly, P. C., and Allison, A. C., 1972, Suppression of established Friend virus leukemia by statolon. IV. Role of humoral antibody in the development of a dormant infection, J. Natl. Cancer Inst. 48: 665.

    PubMed  CAS  Google Scholar 

  • Wheelock, E. F., TOY, S. T., Weislow, O. S., and Levy, M. H., 1974, Restored immune and nonimmune functions in Friend virus leukemic mice treated with statolon, Prog. Exp. Tumor Res. 19: 369.

    PubMed  CAS  Google Scholar 

  • Yamazaki, H., Nitta, K., and Umezawa, H., 1973, Immunosuppression induced with cell-free fluid of Ehrlich carcinoma ascites and its fractions, Gann 64: 83.

    PubMed  CAS  Google Scholar 

  • Youn, J. K., and Barski, G., 1966, Interference between lymphocytic choriomeningitis and Rauscher leukemia in mice, J. Natl. Cancer Inst. 37: 381.

    PubMed  CAS  Google Scholar 

  • Youn, J. K., Barski, G., and Huppert, J., 1968, Inhibition de leucémigenèse virale chez la souris par traitement avec polynucléotides synthétiques, C. R. Acad. Sci. Paris 267: 816.

    CAS  Google Scholar 

  • Young, C. W., 1971, Interferon induction in cancer with some observations on the clinical effects of poly I:C, Med. Clin. North Amer. 55: 721.

    CAS  Google Scholar 

  • Zakay-Roness, Z., and Bernkopf, H., 1964, Effect of active and ultraviolet-irradiated inactive vaccinia virus on the development of Shay leukemia in rats, Cancer Res. 24: 373.

    PubMed  CAS  Google Scholar 

  • Zeleznick, L. D., and Bhuyan, B. K., 1969, Treatment of leukemic (L1210) mice with double-stranded polyribonucleotides, Proc. Soc. Exp. Biol. Med. 130: 126.

    PubMed  CAS  Google Scholar 

  • Zubrod, C. G., 1972, Chemical control of cancer, Proc. Natl. Acad. Sci. U.S.A. 69: 1042.

    CAS  Google Scholar 

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  1. Institut de Recherches Scientifiques sur le Cancer, Villejuif, France

    Ion Gresser

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  1. M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Gresser, I. (1977). Antitumor Effects of Interferon. In: Becker, F.F. (eds) Chemotherapy. Cancer, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6628-1_18

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