Abstract
This chapter highlights facets of a broad range of topics that collectively encompass the “nitrate-nitrite problem.” The overview portrays the current status of an area with potentially important ramifications in regard to aspects of mutagenesis/carcinogenesis and, thus, in regard to public health. The reader will encounter citation of some older literature that appears neglected but merits reconsideration in the light of modern knowledge. The reader will also encounter mention of numerous gaps in current knowledge that seem to hinder critical evaluation of the nitrate-nitrite problem. Many of these gaps can be readily filled by further research. In no case is it intended that the final word has been said or that all pertinent and important documentation has been exhaustively reviewed and discussed. Many unsettled issues remain, and in fact differences of opinion prevail more often than not. It is hoped that some balance has been achieved in presentation of the most controversial points. Certainly, the reader is referred to the original literature that contains the data and theses on which the segments of this review were built. Nothing really new is presented in this review— just a way of looking at things that, in itself, may suggest new critical experimentation and analysis.
This chapter is Contribution No. 1044 of the Department of Biology, The Johns Hopkins University.
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Hartman, P.E. (1982). Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology. In: de Serres, F.J., Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6625-0_6
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