Skip to main content

Physical Carcinogenesis: Radiation—History and Sources

  • Chapter
Book cover Etiology: Chemical and Physical Carcinogenesis

Part of the book series: Cancer, A Comprehensive Treatise ((C))

  • 22 Accesses

Abstract

More than half a century has elapsed since the carcinogenic effects of radiation were first recorded. Study of such effects has since received continuing impetus from the early and expanding uses of radiation in diagnosis and therapy, and from the far-reaching applications of nuclear technology in science, medicine, and industry. In historical perspective, the effects of radiation have received greater study than those of any other physical agent of comparable environmental significance. As such, our experience with radiation is applicable to the study and control of other environmental carcinogens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aub, J. C., Evans, R. D., Hempelmann, L. H., and Martland, H. S., 1952, The late effects of internally-deposited radioactive materials in man, Medicine 31 (3): 221–329.

    Article  CAS  PubMed  Google Scholar 

  • Bener, P., 1969, Spectral intensity of natural ultraviolet radiation and its dependence on various parameters, in: The Biologic Effects of Ultraviolet Radiation ( F. Urbach, ed.), pp. 351–358, Pergamon Press, New York.

    Google Scholar 

  • Brues, A. M., 1951, Carcinogenic effects of radiation, Advan. Biol. Med. Phys. 2: 171–191.

    Article  CAS  Google Scholar 

  • Cade, S., 1957, Radiation induced cancer in man, Brit. J. Radiol. 30: 393–402.

    Article  CAS  PubMed  Google Scholar 

  • Casarett, G. W., 1965, Experimental radiation carcinogenesis, Prog. Exp. Tumor Res. 7: 82.

    Google Scholar 

  • Cole L. J., and Nowell, P. C., 1965, Radiation carcinogenesis: The Sequence of events, Science 150: 1782.

    Article  CAS  PubMed  Google Scholar 

  • Conard, R. A., Dobyns, B. M., and Sutow, W. W., 1970, Thyroid neoplasia as a late effect of acute exposure to radioactive iodines in fallout, Dama 214: 316–324.

    CAS  Google Scholar 

  • Corry, P. M., and Cole, A., 1968, Radiation-induced double strand scission of the Dna mammalian metaphase chromosomes, Radiation Res. 36: 528–543.

    Article  CAS  PubMed  Google Scholar 

  • Court Brown, W. M., and Doll, R., 1957, Leukemia and Aplastic Anemia in Patients Irradiated for Ankylosing Spondylitis, Medical Research Special Report Series, No. 295, H.M.S.O., London.

    Google Scholar 

  • Court Brown, W. M., and Doll, R., 1965, Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis, Brit. Med. J. 2: 1327–1332.

    Article  CAS  PubMed  Google Scholar 

  • Cronkite, E. P., Moloney, W., and Bond, V. P., 1960, Radiation leukemogenesis, an analysis of the problem, Am. J. Med. 5: 673–682.

    Article  Google Scholar 

  • DE Silva Horta, J., Abbat, J. D., Cayolla DA Motta, L. A. R. C., and Roriz, M. L., 1965, Malignancy and other late effects following administration of thorotrast, Lancet 2: 201.

    Article  Google Scholar 

  • Evans, R. D., 1966, The effects of skeletally deposited alpha-ray emitters in man, Brit. J. Radiol. 39: 881–895.

    Article  CAS  PubMed  Google Scholar 

  • Federal Radiation Council, 1960, Report No. 1: Background Material for the Development of Radiation Protection Standards, Government Printing Office, Washington, D.C.

    Google Scholar 

  • Fox, B. W., and Lajtha, L. G., 1973, Radiation damage and repair, Brit. Med. Bull. 29: 16–22.

    CAS  PubMed  Google Scholar 

  • Frieben, A., 1902, Demonstration lines cancroids des rechten Handrückens, das sich nach langdauernder Einwirkung von Röntgenstrahlen entwickelt hatte, Fortschr. Geb. Röntgenstr. 6: 106.

    Google Scholar 

  • Fruth, J., and Lorenz, E., 1954, Carcinogenesis by ionizing radiations, in: Radiation Biology, Vol. 1 ( A. Hollaender, ed.), pp. 1145–1201, McGraw-Hill, New York.

    Google Scholar 

  • Glasser, O., 1944, Radiation spectrum, in: Medical Physics ( O. Glasser, ed.), p. 1969, Year Book Publishers, Chicago.

    Google Scholar 

  • Hempelmann, L. H., 1969, Risk of thyroid neoplasms after irradiation in childhood, Science 160: 159–163.

    Article  Google Scholar 

  • Hesse, O., 1911, Symptomalologie, Pathogenese und Therapie des Röntgenkarzinoms, J. A. Barth, Leipzig.

    Google Scholar 

  • Hutchinson, F., and Rauth, A. M., 1962, The characteristics of the energy loss of spectrum for fast electrons which are important in radiation biology, Radiation Res. 16: 598.

    Google Scholar 

  • International Commission ON Radiological Protection, 1960, Report of Committee III: Protection Against X-Rays up to Energies of 3 Mev and Beta- and Gamma-Rays from Sealed Sources, Pergamon Press, New York.

    Google Scholar 

  • International Commission ON Radiological Protection, 1966, The evaluation of risks from radiation, Health Phys. 12: 239–302.

    Google Scholar 

  • International Commission ON Radiological Protection, 1969, Publication 14: Radiosensitivity and Spatial Distribution of Dose, Reports prepared by Two Task Groups of Committee 1 of the International Commission on Radiological Protection, Pergamon Press, New York.

    Google Scholar 

  • Ishimaru, T., Hoshimo, T., Ichimaru, M., Okada, A., Tomiyasu, T., Tsuchimoto, T., and Yamamoto, T., 1971, Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950–30 September, 1966, Radiation Res. 45: 216–233.

    Article  CAS  PubMed  Google Scholar 

  • Jablon, S., and Kato, H., 1970, Childhood cancer in relation to prenatal exposure to A-bomb radiation, Lancet 2: 1000–1003.

    Article  CAS  PubMed  Google Scholar 

  • Kanazir, D. T., 1969, Radiation-induced alterations in the structure of deoxyribonucleic acid and their biological consequences, in: Progress in Nucleic Acid Research and Molecular Biology, Vol. 9, pp. 117–122, Academic Press, New York.

    Google Scholar 

  • Lacassagne, A., 1945a, Les cancers produits par les rayonnements corpusculaires; mécanisme présumable de la cancerisation par les rayons, in Actualities Scientifiques et Industrielles, No. 981, Hermann et Cie, Paris.

    Google Scholar 

  • Lacassagne, A., 1945b, Les cancers produits par les rayonnements électromagnétiques, in Actualités Scientifiques et Industrielles, No. 975, Hermann et Cie, Paris.

    Google Scholar 

  • Lehman, A. R., and Ormerod, M. G., 1970, The replication of Dna in murine lymphoma cells (L5178Y). 1. Rate of replication, Biochim. Biophys. Acta 204: 128–143.

    Article  Google Scholar 

  • Looney, W. B., 1958, Effects of radium in man, Science 127: 630–633.

    Article  CAS  PubMed  Google Scholar 

  • Lundin, F. E., Lloyd, J. W., Smith, E. M., Archer, V. E., and Holaday, D. A., 1969, Mortality of uranium miners in relation to radiation exposure, hard rock mining, and cigarette smoking-1950 through September, 1967, Health Phys. 16: 571–578.

    Article  PubMed  Google Scholar 

  • Lundin, F. E., JR., Wagoner, J. K., and Archer, V. E., 1971, Radon Daughter Exposure and Respiratory Cancer: Quantitative and Temporal Aspects, NioshHiehs Joint Monograph No. 1, U.S. Public Health Service, Bethesda, Md.

    Google Scholar 

  • Mackenzie, I., 1965, Breast cancer following multiple fluoroscopies. Brit. J. Cancer 19: 1–8.

    Article  CAS  PubMed  Google Scholar 

  • Macmahon, B., and Hutchison, G. B., 1964, Prenatal X-ray and childhood cancer: A review, Acta Unio Int. Contra Cancrum 20: 1172–1174.

    CAS  PubMed  Google Scholar 

  • Malling, H. V., Zzzz DE Serres, E. J., 1969, Identification of the spectrums of X-ray-induced intragenic alterations at the molecular level in Neurospora crassa, Jap. J. Genet. 44: 61 (Suppl. 2).

    Google Scholar 

  • Marinelli, L. D., 1958, Radioactivity and the human skeleton, Am. J. Roentgenol. 80: 729–739.

    CAS  Google Scholar 

  • Martland, H. S., 1931, The occurrence of malignancy in radioactive persons: A general review of data gathered in the study of the radium dial painters, with special reference to the occurrence of osteogenic sarcoma and the interrelationship of certain blood diseases, Am. J. Cancer 15: 2435–2516.

    Google Scholar 

  • Medical Research Council, 1956, The Hazards to Man of Nuclear and Allied Radiations, H.M.S.O., London.

    Google Scholar 

  • Medical Research Council, 1960, The Hazards to Man of Nuclear and Allied Radiations: A Second Report to the Medical Research Council, H.M.S.O., London.

    Google Scholar 

  • Mohs, T. B., 1952, Roentgen-ray cancer of the hands of dentists, J. Am. Dent. Assoc. 45: 160–164.

    CAS  Google Scholar 

  • Morgan, K. Z., 1967, History of damage and protection from ionizing radiation, in Principles of Radiation Protection: A Textbook of Health Physics ( K. Z. Morgan and J. E. Turner, eds.), pp. 1–75, Wiley, New York.

    Google Scholar 

  • Myrden, J. A., and Hiltz, J. E., 1969, Breast cancer following multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis, Canad. Med. Assoc. J. 100: 1032–1034.

    CAS  PubMed  Google Scholar 

  • National Academy OF Sciences-National Research Council, 1956, The Biological Effects of Atomic Radiation: Summary Reports, Washington, D.C.

    Google Scholar 

  • National Academy OF Sciences-National Research Council, 1960, The Biological Effects of Atomic Radiation: Summary Reports, Washington, D.C.

    Google Scholar 

  • National Academy OF Sciences-National Research Council, 1972, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, Report of the Advisory Committee on the Biological Effects of Ionizing Radiations, Washington, D.C.

    Google Scholar 

  • Palmiter, C. C., and Tompkins, P. C., 1965, Guides, standards, and regulations from the Federation Radiation Council point of view, Health Phys. 2: 865–868.

    Article  Google Scholar 

  • Pochin, E. E., 1969, Long-term hazards of radioiodine treatment of thyroid cancer in: Thyroid Cancer, Uicc Monograph Series, Vol. 12, pp. 293–304, Springer, Berlin.

    Google Scholar 

  • Pochin, E. E., 1972, Frequency of induction of malignancies in man by ionizing radiation, in: Encyclopedia of Medical Radiology (A. Zuppinger and O. Hug, eds.), pp. 341–355, Springer, Berlin.

    Google Scholar 

  • Spiess, H., and Mays, C. W., 1970, Bone cancers induced by 224 ra (Th X) in children and adults, Health Phys. 19: 713–720.

    Article  CAS  PubMed  Google Scholar 

  • Stair, R., 1969, Measurement of natural ultraviolet radiation: Historical and general introduction, in: The Biologic Effects of Ultraviolet Radiation ( F. Urbach, ed.), pp. 377–390, Pergamon Press, New York.

    Google Scholar 

  • Stewart, A., Webb, J., and Hewitt, D. A., 1958, A survey of childhood malignancies, Brit. Med. J. 1: 1495–1508.

    Article  CAS  PubMed  Google Scholar 

  • Stone, R. S., 1957, Common sense in radiation protection applied to clinical practice, Am. J. Roentgenol. Radium Ther. Nuclear Med. 78: 993–999.

    CAS  Google Scholar 

  • Stone, R. S., 1959, Maximum permissible exposure standards, in: Protection in Diagnostic Radiology, Rutgers University Press, New Brunswick, N.J.

    Google Scholar 

  • United Nations, 1958, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, General Assembly, Official Records: 13th Session, Suppl. No. 17 (A/3838), New York.

    Google Scholar 

  • United Nations, 1962, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, General Assembly, Official Records: 17th Session, Suppl. No. 16 (A/5216), New York.

    Google Scholar 

  • United Nations, 1964, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, General Assembly, Official Records: 19th Session Suppl. No. 14 (A/5814), New York.

    Google Scholar 

  • United Nations, 1966, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, General Assembly, Official Records: 21st Session, Suppl. No. 14 (A/6314), New York.

    Google Scholar 

  • United Nations, 1969, Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, Official Records of the General Assembly, 24th Session, Suppl. No. 13 (A/7613), New York.

    Google Scholar 

  • United Nations, 1972, Ionizing Radiation: Levels and Effects, A Report of the United Nations Scientific Committee on the Effects of Atomic Radiation, General Assembly, Official Records: 27th Session, Suppl. No. 25 (A/8725), New York.

    Google Scholar 

  • Upton, A. C., 1967, Comparative observations on radiation carcinogenesis in man and animals, in: Carcinogenesis: A Broad Critique pp. 631–675, University of Texas, M. D. Anderson Hospital and Tumor Institute, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Upton, A. C., 1968, Radiation carcinogenesis, in: Methods in Cancer Research, Vol. IV (H. Busch, ed.), pp. 53–82, Academic Press, New York.

    Google Scholar 

  • Von Jagie, N., Scwarz, G., and Von Sienbenrock, L., 1911, Blutbefunde bei Rontgenologon, Berl. Klin. Wschr. 48: 1220–1222.

    Google Scholar 

  • Wald, N., Thoma, G. E., JR., and Brown, G., 1962, Hematologic manifestations of radiation exposure in man, in: Progress in Hematology, Vol. 3, pp. 1–52, Grune and Stratton, New York.

    Google Scholar 

  • Weller, C. V., 1956, Causal Factors in Cancer of the Lung, pp. 43–47, Thomas, Springfield, I II.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer Science+Business Media New York

About this chapter

Cite this chapter

Upton, A.C. (1982). Physical Carcinogenesis: Radiation—History and Sources. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6598-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6600-7

  • Online ISBN: 978-1-4615-6598-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics