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Neoantigen Expression in Chemical Carcinogenesis

  • Chapter
Etiology: Chemical and Physical Carcinogenesis

Part of the book series: Cancer, A Comprehensive Treatise ((C))

Abstract

Neoplastic transformation induced by chemical carcinogens results in the expression in transformed cells of antigens that are not present in their normal cell counterpart, at least in the adult host. In early studies with chemically induced tumors (Foley, 1953; Baldwin, 1955; Prehn and Main, 1957), neoantigens were defined by their capacity to elicit immunity to transplanted tumor and were termed “tumor-specific transplantation antigens.” It is now evident that immune responses are elicited against these antigens in the autochthonous host, and considerable effort has been directed to resolve their role as a limiting (or enhancing) component of chemical carcinogenesis. It is appropriate to refer to these classical neoantigens, which are characterized by an immunological specificity that is unique to individual tumors, as “tumor-associated rejection antigens” (the term “tumor-specific” has been avoided here since recent experiments have raised the possibility that these antigens may be induced in nontransformed cells and so cannot be viewed as specific markers of malignancy).

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  1. Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, England

    Robert W. Baldwin & Michael R. Price

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  1. Robert W. Baldwin
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  1. Department of Anatomic and Research Pathology, M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Baldwin, R.W., Price, M.R. (1982). Neoantigen Expression in Chemical Carcinogenesis. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_14

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