Abstract
Metastases represent perhaps the single most important hindrance to improved cancer patient survival. The formation of metastases is the culmination of a complex series of tumor cell-host interactions called the metastatic cascade (Figure 1; 1,2). During tumor progression, tumor cells become separated from the primary tumor mass and invade into the surrounding tissue. Occasionally, tumor cells will invade blood vessels or lymphatics (intravasation) and are readily disseminated throughout the host. A relatively small percentage of the circulating tumor cells will arrest at the vessel wall and invade into the surrounding tissue (extravasation) to establish a secondary tumor site (3–5). The interaction of the circulating tumor cells with host immune cells may result in destruction of the tumor cells, whereas interaction with host platelets and/or blood coagulation components may enhance the metastatic process. Evidence for the involvement of platelets in metastasis has been demonstrated by several investigators (for review see 6,7). Enhancement of tumor cell arrest and adhesion to the vessel wall by platelets has been postulated as the mechanism for this phenomenon, but its exact nature is undetermined. Because of the potent effects of arachidonic acid metabolites (i.e., prostacyclin and thromboxane A2) on platelet function, we have hypothesized that tumor cells shift the balance between these metabolites in favor of platelet aggregation (8). We have previously proposed the use of modifiers of arachidonic acid metabolism as antimetastatic agents, although the efficacy of antimetastatic therapy with these modifiers has been inconsistent. Prostacyclin (PGI2) has been recently shown to reduce the incidence of pulmonary.
Keywords
- Circulate Tumor Cell
- Arachidonic Acid Metabolism
- Arachidonic Acid Metabolite
- Metastatic Cascade
- W256 Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
I.J. Fidler, D.M. Gersten and I.R. Hart The biology of cancer invasion and metastasis. Adv. Cancer Res. 28:149–250 (1985).
G.L. Nicolson Cancer metastasis. Organ colonization and the cell surface properties of malignant cells. Biochem. Biophys. Acta 113–176 (1982).
L. Weiss, Cancer cell traffic from the lungs to the liver: an example of metastatic inefficiency. Int. Cancer 25:385–392 (1980).
L. Weiss, Metastatic inefficiency. In: “Tumor Invasion and Metastasis” (L.A. Liotta and I.R. Hart, Eds), pp. 81–98. Martinus-Nijhoff, The Hague, 1982.
L. Weiss, Overview of the metastatic cascade. In: “Hemostatic Mechanisms and Metastasis” (K.V. Honn and B.F. Sloane, Eds), pp. 15–38. Martinus-Nijhoff, The Hague, 1983.
K.V. Honn and B.F. Sloane (Eds.), “Hemostatic Mechanisms and Metastasis”. Martinus Nijhoff, the Hague, 1983.
G.A. Jamieson (Ed.), “Interaction of Platelets and Tumor Cells”. Alan R. Liss, New York, 1982.
K.V. Honn, W.D. Busse and B.F. Sloane, Commentary. Prostacyclin and thomboxanes. Implications for their role in tumor cell metastasis. Biochem. Pharmacol. 32:1–11 (1983).
K.V. Honn, D.G. Menter, J.M. Onoda, J.D. Taylor and B.F. Sloane. Role of Prostacyclin as a natural deterrent to hematogenous tumor metastasis. In: “Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects” (G.L. Nicolson and L. Milas, Eds), pp. 361–388. Raven Press, New York, 1984.
K.V. Honn, B. Cicone and A. Skoff, Prostacyclin: a potent antimetastatic agent. Science 212:1270–1272 (1981).
K.V. Honn and J.R. Dunn, Nafazatrom (Bay g 6575) inhibition of tumor lipoxygenase activity and cellular proliferation. FEES Lett. 139: 65–68 (1982).
K.V. Honn, Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system. lin. Metastases 1:103–114 (1983).
K.V. Honn, D. Menter, C. Moilanen, P.G. Cavanaugh, J.D. Taylor and B.F. Sloane, Role of prostacyclin and thromboxanes in tumor cell-platelet-vessel wall interactions. In: “Protective Agents in Cancer” (D.C.H. Mrian and T.F. Slater, Eds.), pp. 57–79. Academic Press, New York, 1983.
D.G. Menter, J.M. Onoda, J.D. Taylor and K.V. Honn. Effects of prostacyclin on tumor cell-induced platelet aggregation. Cancer Res. 44:450–456, 1984.
K.V. Honn and B.F. Sloane, Prostacyclin, thromboxanes and hematogenous metastasis. M. Prostaglandin Thromboxane Leukotriene 12:313–318 (1983).
K.V. Honn, D. Menter, P.G. Cavanaugh, G. Neagos, D. Moilanen, J.D. Taylor and B. F. Sloane, A review of prostaglandins and the treatment of tumor metastasis. Acta Clin. Belg. 38:53–67 (1983).
S. Moncada and J.R. Vane, The discovery of prostacyclin (PGX): a fresh insight into arachidonic acid metabolism. In: “Biochemical Aspects of Prostaglandins and Thromboxanes” (N. Kharasch and J. Fried, Eds.), pp. 155–177. Academic Press, New York, 1977.
J. Fantone, S. Kunkel and J. Varani, Inhibition of tumor cell adherence by prostaglandins. In: “Prostaglandins and Cancer” (T.J. Powles, R.S. Bookman, K.V. Honn and P. Ramwell, Eds.), pp. 673–677. Alan R. Liss, New York, 1982.
Y. Hara, M. Steiner and M.G. Baldini. Characterization of the platelet aggregating activity of tumor cells. Cancer Res. 111:1217–1222 (1980).
J.A. Frangos, L.V. Mclntire, S.G. Eskin and C.L. Ives, Flow effects on prostacyclin production by cultured human endothelial cells. Science 227:1477–1479 (1985).
C.F. Dewey Jr., Effect of fluid flow on living vascular cells. In: Proceedings of Poster Communications, 7th International Symposium on Athersclerosis, p. 190. Int. Atherosclerosis Soc., 1984.
W.E. Stehbens, Hemodynamics and atherosclerosis. Biorheology 19:95–101 (1983).
D.G. Menter, B.W. Steinert, J.M. Onoda, J.D. Taylor and K.V. Honn. Development of a new aggregometry model using microcarrier grown endothelial cells to examine tumor cell-platelet-endothelial cell interactions. J. Cell Biol. 103:471a (1986)
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© 1987 Plenum Press, New York
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Steinert, B.W., Sloane, B.F., Menter, D.G., Crissman, J.D., Taylor, J.D., Honn, K.V. (1987). Role of Eicosanoids in Tumor Cell-Platelet-Endothelial Cell Interactions. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_10
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DOI: https://doi.org/10.1007/978-1-4615-6462-1_10
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