Prophages and Cryptic Prophages

  • Allan M. Campbell

Abstract

A large group of natural bacteriophages (called temperate) can establish a permanent relationship with their hosts (lysogeny), where most viral functions are repressed and the phage genome (prophage) is transmitted vertically from mother to daughters at cell division. Some prophages are inserted into the bacterial chromosome (either by site-specific recombination, like coliphage λ, or by transposition, like coliphage Mu-1), whereas others, like coliphage P1, establish themselves as plasmids. Established lysogens frequently suffer mutations or partial prophage deletions that destroy genes needed for lytic development. The prophage in such cases is called defective or cryptic.

Keywords

Phage Genome Bacterial Chromosome Phage Gene Integrase Gene mcrA Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anilionis, A. and M. Riley. 1980. Conservation and variation of nucleotide sequences within related genomes: Escherichia coli strains. J. Bacteriol. 143:355–365.PubMedGoogle Scholar
  2. Barondes, J. J. and J. Beckwith. 1990. A bacterial virulence determinant encoded by lysogenic coliphage lambda. Nature 346:871–874.CrossRefGoogle Scholar
  3. Barreiro, V. and E. Haggård-Ljungquist. 1992. Attachment sites for bacteriophage P2 on the Escherichia coli chromosome. DNA sequences, localization on the physical map, and detection of a P2-like remnant in E. coli K-12 derivatives. J. Bacteriol. 174:4086–4093.PubMedGoogle Scholar
  4. Dosch, D. C., G. K. Helmer, S. H. Sutton, et al. 1991. Genetic analysis of potassium transport loci in Escherichia coli: evidence for three constitutive systems moderating uptake of potassium. J. Bacteriol. 173:687–696.PubMedGoogle Scholar
  5. Espion, D., K. Kaiser, and C. Dambly-Chaudiere. 1983. A third defective prophage of Escherichia coli K12 defined by the λ derivative, λ-qin III. J. Mol. Biol. 170:611–633.PubMedCrossRefGoogle Scholar
  6. Greener, A. and C. W. Hill. 1980. Identification of a novel genetic element in Escherichia coli K-12. J. Bacteriol. 144:312–321.PubMedGoogle Scholar
  7. Highton, P. J., Y. Chang, W. R. Marcotte, Jr. and C. A. Schnaitman. 1985. Evidence that the outer membrane porin protein gene nmpC of Escherichia coli K-12 lies within the defective qsr’ prophage. J. Bacteriol. 162:256–262.PubMedGoogle Scholar
  8. Kaiser, K. and N. Murray. 1980. On the nature of SbcA mutations in E. coli K-12. Mol. Gen. Genet. 179:555–563.PubMedCrossRefGoogle Scholar
  9. Lederberg, E. M. 1951. Lysogenicity in E. coli K12. Genetics 36:560.Google Scholar
  10. Lindsey, D. R., D. A. Mullins, and J. P. Walker. 1989. Characterization of the cryptic lambdoid prophage DLP12 of Escherichia coli and overlap of the DLP12 integrase gene with the tRNA gene argU. J. Bacteriol. 171:6197–6205.PubMedGoogle Scholar
  11. Parma, D. H., M. Snyder, S. Sobolevski, et al. 1972. The Rex system of bacteriophage λ tolerance and altruistic cell death. Genes Dev. 6:497–510.CrossRefGoogle Scholar
  12. Stoltzfus, A. B. 1991. A survey of natural variation in the trp-ton region of the E. coli chromosome. Ph.D. thesis, University of Iowa, 234 pp.Google Scholar
  13. Strathern, A. and I. Herskowitz. 1975. Defective prophage in Escherichia coli K12 strains. Virology 67:136–148.PubMedCrossRefGoogle Scholar
  14. Thurm, P. and A. J. Garro. 1975. Isolation and characterization of prophage mutants of the defective Bacillus subtilis bacteriophage PBSX. J. Virol. 16:184–191.PubMedGoogle Scholar
  15. Yagil, E., L. Dorgai, and R. Weisberg. 1995. Identifying determinants of recombination specificity: construction and characterization of chimeric bacteriophage integrases. J. Mol. Biol. 252:163–177.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1998

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  • Allan M. Campbell

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