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Detection of Mitochondrial Diseases pp 305–319Cite as

Reactive oxygen species, mitochondria, apoptosis and aging

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Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB,volume 21)

Abstract

In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent Superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA. (Mol Cell Biochem 174: 305–319, 1997)

Key words

  • mitochondrial metabolism
  • mitochondrial DNA
  • superoxide radicals

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Authors and Affiliations

  1. Institute of Medical Biochemistry and Chemistry, University of Bari, Bari, Italy

    S. Papa

  2. A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

    V. P. Skulachev

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  1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

    Frank Norbert Gellerich & Stephan Zierz & 

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Papa, S., Skulachev, V.P. (1997). Reactive oxygen species, mitochondria, apoptosis and aging. In: Gellerich, F.N., Zierz, S. (eds) Detection of Mitochondrial Diseases. Developments in Molecular and Cellular Biochemistry, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6111-8_47

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