Reactive oxygen species, mitochondria, apoptosis and aging

  • S. Papa
  • V. P. Skulachev
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 21)


In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent Superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA. (Mol Cell Biochem 174: 305–319, 1997)

Key words

mitochondrial metabolism mitochondrial DNA superoxide radicals 


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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • S. Papa
    • 1
  • V. P. Skulachev
    • 2
  1. 1.Institute of Medical Biochemistry and ChemistryUniversity of BariBariItaly
  2. 2.A.N. Belozersky Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia

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