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Effect of Tensile Stress in Vascular Remodeling

  • Chapter
Arterial Remodeling: A Critical Factor in Restenosis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 198))

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Abstract

In a review on the biophysics of the mechanoreception, Sachs wrote ten years ago that “mechanoreception is the most widely distributed sensory modality in animals. It subserves the conscious senses of hearing, orientation to local gravity, and touch. It provides the voluntary musculature with information about distension and tension which is required for coordinated movement. It provides the viscera with the ability to sense blood pressure, lung, gut, bladder, and mammary inflation. It may also be used to transduce osmotic pressure: from sex to gas pain mechanoreceptors are there” (1). In the vascular system smooth muscle cells (SMC) and endothelial cells are constantly exposed to mechanical stresses. This overview will focus on the effects of tensile stress and stretch on the arterial wall, and the possible signaling pathways involved in the transduction of the mechanical signal in SMC.

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Authors and Affiliations

  1. Biology of the Vascular Wall, Unit 141 of INSERM, Paris, France

    Alain Tedgui & Bernard Levy

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  1. Alain Tedgui
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  2. Bernard Levy
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Editors and Affiliations

  1. Necker University, Paris, France

    Antoine Lafont

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Eric J. Topol

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Tedgui, A., Levy, B. (1997). Effect of Tensile Stress in Vascular Remodeling. In: Lafont, A., Topol, E.J. (eds) Arterial Remodeling: A Critical Factor in Restenosis. Developments in Cardiovascular Medicine, vol 198. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6079-1_22

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  • DOI: https://doi.org/10.1007/978-1-4615-6079-1_22

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