Abstract
Abnormalities in Carbohydrate metabolism in cirrhosis have been known for very many years and the term hepatogenous diabetes was coined by Naunyn in 1906 to describe those patients with cirrhosis where diabetes was also present. Overt diabetes is now recognised in about 30% of cirrhotics whereas abnormalities of glucose tolerance occur in excess of 50% 1.
Keywords
- Growth Hormone
- Overt Diabetes
- Portacaval Shunt
- Peripheral Glucose Uptake
- Euglycaemic Hyperinsulinaemic Clamp
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Shmueli E, Record CO & Alberti K G M M. Liver diseases, carbohydrate metabolism and diabetes. Clin Endocrinol and Metabol 1992; 6: 719–743.
Ferrannini E, Wahren J, Faber OK et al. Splanchnic and renal metabolism of insulin in human subjects: A dose response study. Am J Physiology 1983; 244: E517–E527.
Greco AV, Crucitti F, Ghirlanda G et al. Insulin and glucagon concentrations in portal and peripheral veins in patients with hepatic cirrhosis. Diabetologia 1979; 17: 23–28.
Pelkonen R, Kallio H, Suranta H, Karonen SI, Plasma insulin, C-peptide and blood glucose in portal, hepatic and peripheral veins in liver cirrhosis. Effect of intravenous tolbutamide. Acta Endocrinologies 1981; 97: 496–502.
Olmishi K, Mishima A, Takashi Me et al. Effects of intra and extra hepatic portal systemic shunts on insulin metabolism. Digestive Diseases and Sciences 1983; 28: 201–206.
Nygren A, Adner N, Sunblad L, Wiechel K. Insulin uptake by the human alcoholic cirrhotic liver. Metabolism 1985; 34: 48–52.
Johnston DG, Alberti KGMM, Faber OK, Binder C, Wright R. Hyperinsulinism of hepatic cirrhosis: Diminished degradation or hypersecretion. Lancet 1977; i: 10–12.
Riggio O, Merli M, Cangiano C et al. Glucose intolerance in liver cirrhosis. Metabolism 1982; 31: 627–634.
Shankar TP, Solomon SS, Duckworth WC et al. Studies of glucose intolerance in cirrhosis of the liver. J Lab and Clin Med 1983; 102: 459–469.
Proietto J, Dudley FJ, Aitken P, Alford FP. Hyperinsuiinaemia and insulin resistance of cirrhosis: The importance of insulin hypersecretion. Clin Endocrinology 1984; 21: 657–665.
Cavallo-Perin P, Cassader M, Bozzo C et al. Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and post receptor defect. J Clin Invest 1985; 75: 1659–1665.
Cavallo-Perin P, Bruno A, Nuccio P et al. Feedback inhibition of insulin secretion is altered in cirrhosis. J Clin Endocrinology & Metabolism 1986; 63: 1023–1027.
Holdsworth CD, Nye L & King E. The effect of portacaval anastomosis on oral carbohydrate tolerance and on plasma insulin levels. Gut 1972; 13: 58–63.
Smith-Laing G, Sherlock S, Faber OK. Effects of spontaneous portal-systemic shunting on insulin metabolism. Gastroenterology 1979; 76: 685–690.
Sherwin RS, Fisher M, Bessoff J et al. Hyperglucagonemia in cirrhosis: Altered secretion and sensitivity to glucagon. Gastroenterology 1978; 74: 1224–1228.
Bosch J, Gomis R, Kravetz D et al. Role of spontaneous portal-systemic shunting in hyperinsulinism of cirrhosis. Am J Physiology 1984; 247: G206–G212.
Taylor R, Heine RI, Collins J, James OFW, Alberti KGMM. Insulin action in cirrhosis. Hepatology 1985; 5:64–71.
Harewood MS, Proietto J, Dudley F, Alford FP. Insulin action and cirrhosis: Insulin binding and lipogenesis in isolated adipocytes. Metabolism 1982; 31: 1241–1246.
Mullen KD, Denne SC, McCullough AJ et al. Leucine metabolism in stable cirrhosis. Hepatology 1986; 6: 622–630.
Petrides AS, Groop LC, Riely CA, DeFronzo RA. Effect of physiological hyperinsulinaemia on glucose and lipid metabolism in cirrhosis. J Clin Invest 1991b; 88: 561–570.
Shmueli E, Alberti KGMM, Record CO. Diacylglycero1protein kinase C signalling: a mechanism for insulin resistance?. J hit Med 1993; 234: 397–400.
Proietto J, Alford FP, Dudley FJ. The mechanism of the carbohydrate intolerance of cirrhosis. J Endocrinology & Metabolism 1980; 51: 1030–1036.
Leatherdale BA, Chase RA, Rogers J et al. Forearm glucose uptake in cirrhosis and its relationship to glucose tolerance. Clinical Science 1980; 59: 191–198.
Butler PC, Thompson CJ, Alberti KGMM, Record CO. The contribution of skeletal muscle to insulin resistance in hepatic cirrhosis. J Hepatology 1987; 56: 515.
Kruszynska Y, Williams N, Perry M, Home PD. The relationship between insulin sensitivity and skeletal muscle enzyme activities in hepatic cirrhosis. Hepatology 1988; 8: 1615–1619.
Shmueli E, Walker M, Alberti G, Record CO. Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis. Hepatology 1993; 18: 86–95.
Moller N, Butler PC, Antsiferov MA, Alberti KGMM. Effects of growth hormone on insulin sensitivity and forearm metabolism in man. Diabetologia 1989; 32: 105–110.
Moller N, Jorgensen JOL, Schmitz O et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiology 1990; 258: E86–E91.
Shmueli E, Stewart M, Alberti KGMM, Record CO. Growth hormone, insulin-like growth factor-1 and insulin resistance in cirrhosis. Hepatology 1994; 18: 322–328.
Shmueli E, Miell JP, Stewart M, Alberti KGMM, Record CO. High insulin-like growth factor binding protein 1 levels in cirrhosis: Link with insulin resistance. Hepatology 1996; 24: 127–133.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Record, C.O. (1997). Glucose and Insulin Metabolism in Cirrhosis. In: Felipo, V., Grisolía, S. (eds) Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy. Advances in Experimental Medicine and Biology, vol 420. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5945-0_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5945-0_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7724-5
Online ISBN: 978-1-4615-5945-0
eBook Packages: Springer Book Archive