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The Tel Gene and Human Leukemias

  • Chapter
Cancer Genes

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 7))

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Abstract

Chromosomal translocations have provided valuable insights into the molecular mechanisms of leukemogenesis in humans. Examples of genes implicated in pathogenesis of hematologic malignancy by virtue of involvement in translocation breakpoints include the PML-RARa fusion associated with t(15;17) acute promyelocytic leukemia (APML, refs. 1–3), the AML1-ETO fusion associated with t(8;21) acute myeloid leukemia (AML, ref.4), the CBFß-MYHII fusion associated with inv(16) acute myelomonocytic leukemia and eosinophilia (5), and MLL fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid leukemias (6).

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Author information

Authors and Affiliations

  1. Division of Hematology/Oncology Department of Medicine, Brigham and Women’s Hospital and Children’s Hospital Harvard Medical School, Boston, Massachusetts, 02115, USA

    Todd R. Golub, George F. Barker, Kimberly Stegmaier & D. Gary Gilliland

Authors
  1. Todd R. Golub
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  2. George F. Barker
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  3. Kimberly Stegmaier
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  4. D. Gary Gilliland
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Editor information

Editors and Affiliations

  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. MIT Center for Cancer Research, Cambridge, Massachusetts, USA

    David Housman

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© 1996 Springer Science+Business Media New York

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Golub, T.R., Barker, G.F., Stegmaier, K., Gilliland, D.G. (1996). The Tel Gene and Human Leukemias. In: Mihich, E., Housman, D. (eds) Cancer Genes. Pezcoller Foundation Symposia, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5895-8_13

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  • DOI: https://doi.org/10.1007/978-1-4615-5895-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7704-7

  • Online ISBN: 978-1-4615-5895-8

  • eBook Packages: Springer Book Archive

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