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Frontiers in Arterial Chemoreception pp 59–64Cite as

PO2 Affinities, Heme Proteins, and Reactive Oxygen Intermediates Involved in Intracellular Signal Cascades for Sensing Oxygen

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

Abstract

The oxygen partial pressure field in different organs ranging from 0 to 100 Torr is likely to be a mirror of oxygen sensitive intracellular signal cascades determining ion channel open probability, metabolic pathway activities and gene expression. High or low PO2 affinities of the particular signal cascade optimize the oxygen sensitive cellular response for adapting organ functions to variations of the oxygen supply conditions. The signal cascades are triggered by an oxygen sensor which is believed to be a heme protein. In some cases reactive oxygen intermediates (ROI) are acting as second messengers revealing these signal cascades as an evolutionary highly conserved principle first described in bacteria.

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References

  • Acker H (1994) Mechanisms and meaning of cellular oxygen sensing in the organism. Respir Physiol 95: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Acker H & Xue D (1995) Mechanisms of oxygen sensing in the carotid body in comparison to other oxygen sensing cells. News Physiol Sci 10: 211–217

    CAS  Google Scholar 

  • Bastian NR, Hibbs JB Jr (1994) Assembly and regulation of NADPH oxidase and nitric oxide synthase. Curr Opin Immunol 6: 131–139

    Article  PubMed  CAS  Google Scholar 

  • Bokoch GM (1993) Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins. Bio-chem J 289: 17–24

    CAS  Google Scholar 

  • Cowan DB, Weisel RD, Williams WG & Mickle DAG (1993) Identification of oxygen responsive elements in the 5′flanking region of the human glutathion peroxidase gene. J Biol Chem 268: 26904–26910

    PubMed  CAS  Google Scholar 

  • Cross AR, Henderson L, Jones OTG, Delpiano MA, Hentschel J & Acker H (1990) Involvement of an NAD(P)H oxidase as a PO2 sensor protein in the rat carotid body. Biochem J 272: 743–747

    PubMed  CAS  Google Scholar 

  • Czyzyk-Krzeska M, Furnari BA, Lawson EE & Millhorn DE (1994) Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem 7: 760–764

    Google Scholar 

  • Fandrey J, Frede S & Jelkmann W (1994) Role of hydrogen-peroxide in hypoxia-induced erythropoietin production. Biochem J 303: 507–510

    PubMed  CAS  Google Scholar 

  • Franco-Obregón A, Ureña J & López-Barneo J (1995) Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. Proc Natl Acad Sci USA 92: 4715–4719

    Article  PubMed  Google Scholar 

  • Gilles-González MA & González G (1993) Regulation of the kinase activity of heme protein FixL from the two-component system FixL/FixJ of Rhizobium meliloti. J Biol Chem 268: 16293–16297

    PubMed  Google Scholar 

  • Gleadle JM, Ebert BL, Firth JD & Ratcliffe PJ (1995) Regulation of angiogenic growth factor expression by hypoxia, transition metals and chelating agents. Am J Physiol 268: C1362–C1368

    PubMed  CAS  Google Scholar 

  • Gleadle JM, Ebert BL & Ratcliffe PJ (1995a) Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia-implications for the mechanism of oxygen sensing. Eur J Biochem 234:92–99

    Article  PubMed  CAS  Google Scholar 

  • Goldberg MA & Schneider ThJ (1994) Similarities between the oxygen sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269: 4355–4359

    PubMed  CAS  Google Scholar 

  • Görlach A, Holtermann G, Jellkmann W, Hancock JT, Jones SA, Jones OTG & Acker H (1993) Photometric characteristics of haem proteins in erythropoietin producing hepatoma cells (HepG2). Biochem J 290: 771–776

    PubMed  Google Scholar 

  • Hidalgo E & Demple B (1994) An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. EMBO J 13: 138–146

    PubMed  CAS  Google Scholar 

  • Jiang Ch & Haddad GG (1994) A direct mechanism for sensing low oxygen levels by central neurons. Proc Natl Acad Sci USA 91: 7198–7201

    Article  PubMed  CAS  Google Scholar 

  • Jones OTG, Jones SA & Wood JD (1995) Expression of components of the superoxide generating NAD(P)H oxidase by human leucocytes and other cells. Protoplasma 184: 79–85

    Article  CAS  Google Scholar 

  • Kamal M, Mohazzab H & Wolin MS (1994) Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol 267: L815–L822

    Google Scholar 

  • Khan AU & Wilson Th (1995) Reactive oxygen species as cellular messengers. Chemistry & Biology 2: 437–445

    Article  CAS  Google Scholar 

  • Kietzmann Th, Schmidt H, Probst I & Jungermann K (1992) Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. FEBS Lett 311: 251–255

    Article  PubMed  CAS  Google Scholar 

  • Kummer W & Acker H (1995) Immunohistochemical demonstration of 4 subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body. J Appl Physiol 78: 1904–1909

    PubMed  CAS  Google Scholar 

  • Lioa JK, Zulueta JJ, Yu FSh, Peng HB, Cote CG & Hassoun PM (1995) Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest 96: 2661–2666

    Article  Google Scholar 

  • López-Barneo J, Benot AR & Ureña J (1993) Oxygen sensing and the electrophysiology of arterial chemoreceptor cells. News Physiol Sci 8: 191–195

    Google Scholar 

  • López-López JR & González C (1992) Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide. FEBS Lett 299: 251–254

    Article  PubMed  Google Scholar 

  • Marti HH, Jung HH, Pfeilschifter J & Bauer C (1994) Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells. Pflügers Arch 429: 216–222

    Article  PubMed  CAS  Google Scholar 

  • McCormack T & McCormack K (1994) Shaker K+ channel ß subunits belong to an NAD(P)H-dependent oxidore-ductase superfamily. Cell 79: 133–1135

    Article  Google Scholar 

  • Montoro RJ, Ureña J, Fernández-Chacón R, Alvarez de Toledo G & López-Barneo J (1996) Oxygen sensing by ion channels and chemotransduction in single glomus cells. J Gen Physiol 107: 133–143

    Article  PubMed  CAS  Google Scholar 

  • Pahl HL & Baeuerle PA (1994) Oxygen and the control of gene expression. BioEssays 16: 497–502

    Article  PubMed  CAS  Google Scholar 

  • Prabhakar NR, Kumar GK, Chang ChH, Agani FH & Haxhiu MA (1993) Nitric oxide in the sensory function of the carotid body. Brain Res 625: 16–22

    Article  PubMed  CAS  Google Scholar 

  • Raff H & Jankowski B (1995) O2 dependence of pregnenolone and aldosterone synthesis in mitochondria from bovine zona glomerulosa cells. J Appl Physiol 78: 1625–1628

    PubMed  CAS  Google Scholar 

  • Russel WJ, Ho YS, Parish G & Jackson RM (1995) Effects of hypoxia on MnSOD expression in mouse lung. Am J Physiol 269: L221–L226

    Google Scholar 

  • Ureña J, Fernández-Chacón R, Benot AR, Alvarez de Toledo G & López-Barneo J (1994) Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells. Proc Natl Acad Sci USA 91: 10208–10211

    Article  PubMed  Google Scholar 

  • Wang ZZ, Bredt DS, Fidone SJ & Stensaas LJ (1993) Neurons synthesizing nitric oxide innervate the mammalian carotid body. J Comp Neurol 336: 419–432

    Article  PubMed  CAS  Google Scholar 

  • Weir EK & Archer StL (1995) The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels, FASEB J 9: 183–189

    PubMed  CAS  Google Scholar 

  • Wyatt CN, Wright C, Bee D & Peers C (1995) O2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proc Natl Acad Sci USA 92: 295–299

    Article  PubMed  CAS  Google Scholar 

  • Youngson Ch, Nurse C, Yeger H & Cutz E (1993) Oxygen sensing in airway chemoreceptors. Nature 365: 153–155

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Max Planck Institut für molekulare Physiologie, 44139, Dortmund, Germany

    Helmut Acker

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  1. Helmut Acker
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Editor information

Editors and Affiliations

  1. Catholic University of Chile, Santiago, Chile

    Patricio Zapata

  2. University of Utah School of Medicine, Salt Lake City, Utah, USA

    Carlos Eyzaguirre

  3. University of Oxford, Oxford, England

    Robert W. Torrance

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© 1996 Springer Science+Business Media New York

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Acker, H. (1996). PO2 Affinities, Heme Proteins, and Reactive Oxygen Intermediates Involved in Intracellular Signal Cascades for Sensing Oxygen. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_7

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7702-3

  • Online ISBN: 978-1-4615-5891-0

  • eBook Packages: Springer Book Archive

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