Abstract
The science of producing transgenic animals is advancing rapidly with the resulting manipulated offspring being utilized for biomedical modeling, possible xenotransplantation to humans and agricultural livestock production. The pig is one species under investigation which could have application in any of the aforementioned categories. We will highlight general facts regarding transgenic livestock, aspects of microinjection and our current work performed on developing the Panepinto micro size pig as an animal model for research requiring genetic manipulation. Specifically, a pilot study was undertaken with a hybrid cross of Yucatan micropigs and Vietnamese potbellied pigs as models for potential transgenic work using superovulatory techniques, follicular harvest and reimplantation. The advantage of using a small, easily managed animal needed to be balanced against the low reproductive efficiency of these pigs as compared to domestic breeds. The pilot study and subsequent followup work demonstrate our early experiences with the model and the direction in which this investigation should proceed.
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© 1996 Springer Science+Business Media New York
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Hampshire, V., Bacher, J., Dennis, M., Wolff, A., Yarko, M. (1996). Early Characterization of Panepinto Micro/Miniature Swine for Use as Transgenic Animal Models. In: Tumbleson, M.E., Schook, L.B. (eds) Advances in Swine in Biomedical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5885-9_23
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DOI: https://doi.org/10.1007/978-1-4615-5885-9_23
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